Mechanical and Physical Properties of Experimental Antifungal Denture Base Resins

Abstract

Many denture wearers suffer from fungal infections, particularly Candida albicans, due to failure to properly clean or remove the prosthesis. These infections can cause denture stomatitis, which often leads to irritated or traumatized tissues. Current denture base materials do not have antifungal properties. We have recently synthesized several new antifungal compounds containing 1,4-diazabicyclo [2.2.2] octane (DABCO) (DC16NF, 1 DC11MAF, C2-DC11MAF) that have shown significant antifungal properties. The purpose of this study is to incorporate these novel antifungal compounds and test mechanical and physical properties of the resulting antifungal materials. The Clotrimazole was also incorporated into denture acrylics and used as a positive control. Samples were then prepared into discs and bars. All groups were tested for flexural strength, flexural modulus, water sorption, and solubility. The results showed that all experimental groups exhibited similar flexural strength as the control, except DC16NF, which had significantly lower strength than the control. DC16NF and DC11MAF both exhibited significantly lower flexural modulus compared to the control while C2DC11MAF exhibited similar flexural modulus as the control. All experimental groups exhibited higher water sorption than the control and a similar or lower solubility as compared to the control. These results suggest that the new antifungal denture base materials possess similar mechanical and physical properties as commercial denture materials, although the formulations can be further optimized. Received: May 14, 2018 Accepted: August 13, 2018 Published: August 29, 2018 Copyright: © 2018 Maldonado K, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Corresponding author: Kyle Maldonado and Xiaoming Xu, Department of Comprehensive Dentistry and Biomaterials, Louisiana State University Health Sciences Center, USA. E-mail: Kylemaldonado90@gmail.com and xxu@lsuhsc.edu Citation: Maldonado K, Xu D, Wang Y, Zhang JF, Hamdan S, Wen ZT, Fidel PL, Noverr MC, Xu X. Mechanical and Physical Properties of Experimental Antifungal Denture Base Resins. Oral Health and Dental Studies. 2018; 1(1):5. Open Access