Polymer Supported Proline-Based Organocatalysts in Asymmetric Aldol Reactions: A Review

IF 0.9 Q4 CHEMISTRY, PHYSICAL Current Organocatalysis Pub Date : 2022-01-12 DOI:10.2174/2213337209666220112094231

Rubina Shajahan, Rithwik Sarang, Anas Saithalavi

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引用次数: 3

Abstract

The use of proline-based organocatalysts has acquired significant importance in organic synthesis, especially in enantioselective synthesis. Proline and its derivatives are proven to be quite effective chiral organocatalysts for a variety of transformations including the aldol reaction, which is considered as one of the important C-C bond forming reactions in organic synthesis. The use of chiral organocatalysts has several advantages over its metal-mediated analogues. Subsequently, a large number of highly efficient proline-based organocatalysts including polymer-supported chiral analogues have been identified for aldol reaction. The use of polymer-supported organocatalysts exhibited remarkable stability under the reaction conditions and offered the best results particularly in terms of its recyclability and reusability. These potential benefits along with its economic and green chemistry advantages have led to the search for many polymer-supported proline catalysts. In this review, recent developments in exploring various polymer immobilized proline-based chiral organocatalysts for asymmetric aldol reactions are described.

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聚合物负载脯氨酸基有机催化剂在不对称醛醇反应中的研究进展

脯氨酸基有机催化剂的使用在有机合成，特别是对映选择性合成中具有重要意义。脯氨酸及其衍生物被证明是一种非常有效的手性有机催化剂，可用于多种转化，包括醛醇反应，醛醇反应被认为是有机合成中重要的C-C键形成反应之一。使用手性有机催化剂与其金属介导的类似物相比有几个优点。随后，大量高效的脯氨酸基有机催化剂(包括聚合物负载的手性类似物)被确定用于醛醇反应。使用聚合物负载的有机催化剂在反应条件下表现出显著的稳定性，并提供了最好的结果，特别是在其可回收性和可重用性方面。这些潜在的好处以及它的经济和绿色化学优势已经导致了许多聚合物负载的脯氨酸催化剂的研究。本文综述了用于不对称醛醇反应的基于脯氨酸的聚合物固定化手性有机催化剂的研究进展。

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.