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Biotransformation of Cinnamic Acid, Cinnamaldehyde, Furfural and Epoxidation of Cyclohexene by Plant Catalase 植物过氧化氢酶对肉桂酸、肉桂醛、糠醛的生物转化和环己烯的环氧化作用
IF 1.1 Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-11-24 DOI: 10.2174/0122133372268423231101072640
Takio Nene, Anindita Hazarika, Meera Yadav
Epoxides are widely useful in various fields such as pharmaceuticals, pesticides, cosmetics, polymer synthesis, fragrance compounds, and food additives. However, the synthesis of epoxides involves heavy metal catalysts and toxic, unstable organic catalysts which causes serious environmental and safety concerns. In recent years, biocatalysts have received a great deal of interest in the synthesis of olefin-derived epoxides due to their mild reaction conditions, environmental friendliness, good selectivity, and sustainability. This study focuses on catalases as a biocatalyst for potential epoxidation reactions of olefins.Objective: To determine the possibility of using biocatalyst catalase from a novel source Sechium edule (squash) for epoxidation of olefins in the presence of H2O2. UV-Vis spectrophotometer was used to monitor the formation of epoxide from substrates- cyclohexene, cinnamic acid, cinnamaldehyde, furfural in acetonitrile solvent and a suitable aliquot of the enzyme solution in the presence of H2O2. The products formed were analyzed using FTIR and GC-MS. For the immobilized enzyme, chitosan beads activated with TPP were used in place of the enzyme and a similar procedure was followed for the analysis. Four different olefin substrates (cyclohexene, cinnamic acid, cinnamaldehyde, and furfural) were selected to study the catalysis reaction of epoxidation by the catalase enzyme. The course of the epoxidation was monitored by UV-Vis, FTIR, and GC-MS methods. However, under optimized reaction conditions and spectral analysis, further confirmed by GC-MS, data showed only epoxide formation from cyclohexene. CAT completely catalyzed other olefins like furfural, cinnamic acid, and cinnamaldehyde into its degraded products biochemically. Therefore, cyclohexene was selected for further immobilization studies and the identified metabolites of olefins and their degradation mechanism. Major biodegradation products of cinnamic acid were found to be styrene( m/z 104.0) and benzaldehyde(m/z 105.0). GC-MS data of biotransformation of cinnamaldehyde, identified 2,4 dimethyl benzaldehyde(m/z 133) as the main product. The catalytic biotransformation of furfural investigated by GC-MS data identified 2,5 dimethyl benzaldehyde (m/z 133), dodecanol (m/z 181) and Pentanoic acid, 5 hydroxy, 2,4 dibutyl phenyl ester(m/z 306) as the major product. Three major oxidized products were detected in GC-MS data from the epoxidation of cyclohexene viz., cyclohexane diol(m/z 116), cyclohexene epoxide-1-ol(m/z 110), cyclohexene epoxide-1-one(m/z 110). In this investigation, catalase purified from Sechium edule(squash) was developed as an efficient catalytic tool for the biotransformation of olefins and selective epoxidation of cyclohexene. Under optimized conditions, the experimental results revealed the main products found in cinnamaldehyde as benzaldehyde (m/z 133.0) and cinnamic acid as benzaldehyde (m/z 133), styrene (m/z 104.0) and benzoic acid (m/z 122.0), wh
环氧化物在制药、杀虫剂、化妆品、聚合物合成、香料化合物和食品添加剂等多个领域具有广泛用途。然而,环氧化物的合成涉及重金属催化剂和有毒、不稳定的有机催化剂,这引起了严重的环境和安全问题。近年来,生物催化剂因其温和的反应条件、环境友好性、良好的选择性和可持续性,在烯烃衍生环氧化物的合成中受到了广泛关注。本研究的重点是将催化剂作为一种生物催化剂用于潜在的烯烃环氧化反应:目的:确定在 H2O2 存在的情况下,使用来自新型来源 Sechium edule(地瓜)的生物催化剂过氧化氢酶进行烯烃环氧化反应的可能性。 使用紫外可见分光光度计监测底物环己烯、肉桂酸、肉桂醛、糠醛在乙腈溶剂和适当等量的酶溶液中,在 H2O2 存在下形成环氧化物的情况。使用傅立叶变换红外光谱(FTIR)和气相色谱-质谱(GC-MS)分析生成的产物。对于固定化酶,则使用用 TPP 活化的壳聚糖珠代替酶,并按照类似的程序进行分析。 选择了四种不同的烯烃底物(环己烯、肉桂酸、肉桂醛和糠醛)来研究催化酶的环氧化催化反应。紫外可见光、傅立叶变换红外光谱和气相色谱-质谱法监测了环氧化反应的过程。然而,在优化的反应条件和光谱分析下,经 GC-MS 进一步确认,数据显示环己烯只生成环氧化物。CAT 可将糠醛、肉桂酸和肉桂醛等其他烯烃完全催化成其生化降解产物。因此,我们选择了环己烯作为进一步固定化研究的对象,并确定了烯烃的代谢产物及其降解机制。肉桂酸的主要生物降解产物是苯乙烯(m/z 104.0)和苯甲醛(m/z 105.0)。肉桂醛生物转化的气相色谱-质谱数据表明,2,4 二甲基苯甲醛(m/z 133)是主要产物。通过 GC-MS 数据研究糠醛的催化生物转化,发现 2,5 二甲基苯甲醛(m/z 133)、十二醇(m/z 181)和戊酸,5 羟基,2,4 二丁基苯基酯(m/z 306)是主要产物。环己烯环氧化反应的气相色谱-质谱数据中检测到三种主要氧化产物,即环己烷二醇(m/z 116)、环己烯环氧化物-1-醇(m/z 110)和环己烯环氧化物-1-酮(m/z 110)。 在这项研究中,从 Sechium edule(壁虱)中纯化的过氧化氢酶被开发为一种高效的催化工具,可用于烯烃的生物转化和环己烯的选择性环氧化。在优化条件下,实验结果表明肉桂醛的主要产物为苯甲醛(m/z 133.0),肉桂酸的主要产物为苯甲醛(m/z 133)、苯乙烯(m/z 104.0)和苯甲酸(m/z 122.0),而糠醛氧化的数据无法与之前的研究相吻合。环己烯环氧化的最佳 CH3CN 溶剂浓度为 4 mM。使用环己烯作为可变底物研究了壳聚糖上游离和固定过氧化氢酶的酶学特性,发现游离过氧化氢酶的 Km 和 Vmax 值分别为 0.017 mM、83.33 μmol/min,pH 值为 6.8,温度为 30˚C;固定过氧化氢酶的 Km 和 Vmax 值分别为 0.03 mM、200 μmol/min,pH 值为 7.6,温度为 35˚C。固定化增加了 CAT 的热稳定性,并使 pH 值变为碱性。推断环己烯的氧化可能是生成环氧化物的自由基链机制,主要产物为环己烷二醇(m/z 116)、环己烯环氧化物-1-醇(m/z 110)和环己烯环氧化物-1-酮(m/z 110)。生物催化工具的可重复使用性为降低各种催化反应的成本提供了机会。进一步的研究可以集中在环氧化物的分离和提高产量、改进固定化策略以实现最大限度的重复循环,以及生物烯烃的化学酶环氧化等方面。
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引用次数: 0
Design of Dendritic Foldamers as Catalysts for Organic Synthesis 枝状折叠体有机合成催化剂的设计
Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-11-10 DOI: 10.2174/0122133372274680231105072522
Smitha George, Sherlymole P. Baby, Sreekumar Krishnapillai
Background:: Multistranded foldamers mimic biopolymer architecture, through the assembly and folding of intrinsically flexible polymeric chains attached to polyol core have been synthesised here. The synthesised dendritic motifs possess helical cavities with properly arranged active sites. As these cavities are large enough to accommodate guest molecules, their application as synthetic foldamer catalyst were investigated in Knoevenagel and Mannich reactions. Methods:: It is presumed to be the potentiality of dendritic foldamers to form reverse micelle in the interior of helical motif containing many reactive sites. Results:: Inside the dendritic foldamer, the substrates are adequately concentrated, work together in cooperation for ligand-binding, and stabilize the transition state as in enzymes that helps to accelerate the reaction rate many times greater than in bulk solution. Conclusion:: An unrivalled reaction rate and high yield of products were obtained within a short time in both Knoevenagel and Mannich reactions by using dendritic foldamers as catalysts.
背景:多链折叠体模拟生物聚合物结构,通过装配和折叠内在柔性聚合物链连接到多元醇核心已经合成。合成的树突基序具有螺旋腔,活性位点排列合理。由于这些空腔足够大,可以容纳客体分子,因此研究了它们在Knoevenagel和Mannich反应中作为合成折叠体催化剂的应用。方法:推测树突状折叠体具有在含有许多活性位点的螺旋基序内部形成反胶团的潜力。结果:在树突状折叠体内部,底物被充分浓缩,在配体结合中协同工作,并稳定过渡状态,就像在酶中一样,有助于加速反应速率,比在体溶液中快许多倍。结论:在Knoevenagel反应和Mannich反应中,枝状折叠物均能在短时间内获得较高的反应速率和产率。
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引用次数: 0
Water Extract of Onion Catalyst: A Sustainable Approach for the Synthesis of 4-Substituted 1,5-Benzodiazepine Derivatives via an In Situ Generated Enaminones 洋葱催化剂的水提物:通过原位生成胺酮合成4-取代1,5-苯二氮卓类衍生物的可持续方法
Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-11-10 DOI: 10.2174/0122133372276924231106052151
Loganathan Selvaraj, Rajendran Eswaran, Vennila Kailasam Natesan, Seenivasa Perumal Muthu
Aim: To develop a green protocol for the one-pot synthesis of biologically active 4- substituted-1,5-benzodiazepine derivatives. Background: Benzodiazepines acquired significant attention in medicinal chemistry owing to their wide spectrum of biological and pharmacological activities such as anti-HIV (reverse transcriptase inhibitor) drugs, HIV-1 protease inhibiting, hepatitis C virus (HCNV) NS5B, anti-malarial, antibacterial, anti-inflammatory, anti-depressant, anti-coagulant, analgesic agents, anti-cancer, cholecystokinin- B receptor antagonists. It was made through three-component condensation of 1,2-diamine, 1,3-cyclic diketone and an aldehyde under various conditions such as (COOH)2/H2O, AcOH/EtOH. Method: 1. To develop simple, convenient and environmentally benign green protocol for the onepot synthesis of 4-substituted-1,5-benzodiazepines through three-component reaction of 1,2-diamine, 1,3-cyclic diketone with an aldehyde catalyzed by water extract of onion. 2. To optimize the reaction conditions. 3. To study scope and mechanism of the reaction 4. To characterize the structure by single crystal X-ray analysis. Result: Finally, EtOH and 0.5 mL of onion extract are suitable for reaction conditions. 4. To examine the electronic effect on reaction time and yields, the aromatic aldehydes having electron releasing functional group such as 4-OH, 4-N,N-dimethyl, 4-OMe, 4-Me, phenyl, and 3,4-dimethoxy gave the desired product in good yields. (90-92%; 5a-5e and 5m). The aromatic aldehydes bearing electron withdrawing group such as 4-Br, 4-Cl, 4-F, 4-CF3, 4-CN, 4-NO2, 3,4-dichloro, 3-bromo- 4-fluoro gave excellent yields (93-97%; 5f-5k, 5n and 5o). 5. Further, to expand the diamine substrates, we have employed 4-hydroxybenzaldehyde 4a, benzaldehyde 4e and 4-nitrobenzaldehyde 4k as model substrates and examined different diamines (4-methylbenzene-1,2-diamine 1b and 4- chlorobenzene-1,2-diamine 1c) with dimedone 2a and gave good yields (89-92%; 5v-5z and 5aa. 6. substituted-1,5-benzodiazepines. Further, the methodology was applied to large-scale reactions. Conclusion: In conclusion, employing aqueous onion extract as a gentle, affordable catalyst, we have developed a simple, effective, and environmentally friendly method for the synthesis of 4- substituted-1,5-benzodiazepines derivatives from 1,2-diamine, diketone, and an aldehyde. Excellent yields, simple workup, inexpensive, non-toxic, and environment-friendly reaction conditions are the prominent features of this procedure.
目的:建立具有生物活性的4-取代-1,5-苯二氮卓类衍生物的绿色一锅合成工艺。背景:苯二氮卓类药物由于具有广泛的生物学和药理活性,如抗hiv(逆转录酶抑制剂)药物、HIV-1蛋白酶抑制剂、丙型肝炎病毒(HCNV) NS5B、抗疟疾、抗菌、抗炎、抗抑郁、抗凝血、镇痛、抗癌、胆囊收缩素- B受体拮抗剂等,在药物化学领域受到了广泛的关注。它是由1,2-二胺、1,3-环二酮和一种醛在(COOH)2/H2O、AcOH/EtOH等不同条件下三组分缩合而成。方法:1。以洋葱水提物为催化剂,1,2-二胺,1,3-环二酮与醛三组分反应,建立一锅法合成4-取代-1,5-苯二氮卓类化合物的简单、方便、环保的绿色方案。2. 优化反应条件。3.研究反应范围和反应机理。用单晶x射线分析表征其结构。结果:最终以乙酸乙酯和0.5 mL洋葱提取物为适宜的反应条件。4. 为了考察电子对反应时间和产率的影响,采用具有电子释放官能团的芳香醛,如4-OH、4-N、n -二甲基、4-OMe、4-Me、苯基和3,4-二甲氧基,得到了产率较高的期望产物。(90 - 92%;5a-5e和5m)。含吸电子基团的芳香醛,如4-溴、4-氯、4-氟、4-CF3、4-CN、4-NO2、3,4-二氯、3-溴- 4-氟,产率优异(93-97%;5f-5k, 5n和5o)。5. 此外,为了扩大二胺底物,我们以4-羟基苯甲醛4a、苯甲醛4e和4-硝基苯甲醛4k为模型底物,用二美酮2a检测了不同的二胺(4-甲基苯-1,2-二胺1b和4-氯苯-1,2-二胺1c),得到了良好的产率(89-92%;5v-5z和5aa。6. substituted-1 5-benzodiazepines。此外,该方法还应用于大规模反应。结论:本研究以水相洋葱提取物为催化剂,建立了一种简单、高效、环保的1,2-二胺、二酮和醛为原料合成4-取代-1,5-苯二氮卓类化合物的方法。收率高、处理简单、价格低廉、无毒、环境友好是该工艺的突出特点。
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引用次数: 0
A Review on the Recent Progress of Layered Double Hydroxides (LDHs)- based Catalysts for Heterocyclic Synthesis 层状双氢氧化物(LDHs)基杂环合成催化剂的研究进展
Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-10-27 DOI: 10.2174/0122133372264682231019101634
Khadija El Farouki, Marieme Kacem, Mustapha Dib, Hajiba Ouchetto, Abderrafia Hafid, Mostafa Khouili
Abstract: Over the past decade, heterocyclic compounds and their derivatives have emerged as promising substances with potential pharmacological applications due to their interesting biological properties. The significance of heterocyclic compounds in drug discovery and development is evident from the fact that a majority of drugs in the pharmaceutical market incorporate heterocyclic compounds as active substances or ingredients. Various synthetic methods and advancements have been devised to prepare these heterocyclic compounds using diverse catalysts under mild conditions. Layered double hydroxides (LDHs)-based materials have gained considerable attention across different fields, and their usability can be significantly enhanced via the selection of metal cations, their molar ratios, surface complexation, and intercalation modifications. The synthesis and application of LDH-based materials as catalysts have garnered increasing interest due to their exceptional properties. Moreover, LDH-based materials have found extensive use as heterogeneous catalysts in the synthesis of numerous heterocyclic compounds. This review presents the latest developments in the catalytic application of LDH-based materials as solid heterogeneous catalysts in the synthesis of heterocyclic compounds, covering literature published from 2018 to 2023.
摘要:在过去的十年中,杂环化合物及其衍生物由于其有趣的生物学特性而成为具有潜在药理应用前景的物质。杂环化合物在药物发现和开发中的重要性是显而易见的,因为制药市场上的大多数药物都将杂环化合物作为活性物质或成分。在温和的条件下,使用不同的催化剂制备这些杂环化合物,已经设计了各种合成方法和进展。层状双氢氧化物(LDHs)基材料在不同的领域得到了相当大的关注,它们的可用性可以通过金属阳离子的选择、它们的摩尔比、表面络合和插层修饰来显着增强。ldh基材料作为催化剂的合成和应用由于其特殊的性能而引起了越来越多的关注。此外,ldh基材料作为多相催化剂已被广泛应用于许多杂环化合物的合成。本文综述了2018年至2023年期间ldh基材料作为固体非均相催化剂在杂环化合物合成中催化应用的最新进展。
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引用次数: 0
Advances in Synthesis of Indazole Variants: A Comprehensive Review of Transition Metal, Acid/Base and Green Chemistry-based Catalytic Approaches 吲哚唑衍生物的合成进展:过渡金属、酸/碱和绿色化学催化方法综述
Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-10-20 DOI: 10.2174/0122133372264656231004032920
Archana Kapoor, Mithlesh Yadav
Background:: Indazole is a heterocyclic motif widely used in medicinal chemistry due to its positive photophysical properties. The development of new methods for synthesizing the indazole scaffold is of great importance in drug discovery. Methods:: This study presents a detailed review of current advances in indazole synthesis, focusing on catalyst-based and green chemistry approaches. The analysis is classified based on acid-base and transition-metal catalysts and green chemistry methods. Catalyst-based advances have given a new impetus to the synthesis of this effective pharmacophore. Results:: The extensive literature on indazole synthesis demonstrates the notable progress achieved through catalyst-based approaches. These methods have enabled researchers to create a wide range of indazole derivatives and analogs, facilitating their application in pharmaceutical products and organic molecules. The use of acid-base and transition-metal catalysts has been particularly effective in enhancing the efficiency and selectivity of indazole synthesis. Conclusion:: Indazoles and their variants are widely used in pharmaceutical products and organic molecules. The recent literature indicates that catalyst-based approaches have resulted in significant advancements in indazole synthesis. This review may be useful for researchers in medicinal chemistry, content chemistry, and agrochemistry.
背景:吲哚唑是一种杂环基序,因其具有良好的光物理性质而广泛应用于药物化学。开发吲哚唑支架的合成新方法对药物发现具有重要意义。方法:综述了吲哚唑合成的最新进展,重点介绍了基于催化剂和绿色化学的合成方法。根据酸碱和过渡金属催化剂以及绿色化学方法对分析进行分类。基于催化剂的进展为这种有效药效团的合成提供了新的动力。结果:大量关于茚唑合成的文献表明,基于催化剂的合成方法取得了显著进展。这些方法使研究人员能够创造出范围广泛的茚唑衍生物和类似物,促进了它们在医药产品和有机分子中的应用。使用酸碱和过渡金属催化剂在提高吲哚唑合成的效率和选择性方面特别有效。结论:茚唑及其衍生物在医药制品和有机分子中有着广泛的应用。最近的文献表明,基于催化剂的方法导致了茚唑合成的重大进展。本文对药物化学、成分化学和农用化学的研究有一定的参考价值。
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引用次数: 0
More Widespread use of Ivermectin for the Treatment of COVID-19 Infec-tion could have Saved Many 更广泛地使用伊维菌素治疗COVID-19感染本可以挽救许多人的生命
Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-10-10 DOI: 10.2174/2213337210666230809141610
Alberto Boretti, Bimal K. Banik
Abstract: Here we review the available literature for the specific use of Ivermectin against COVID-19 infection. Currently, 204 works have been published presenting the results of ivermectin use for COVID-19. 156 are peer-reviewed, and 96 are comparing treatment and control groups. Ivermectin was adopted for early treatment in all or part of 22 countries (39 including non-government medical organizations). The 96 studies of Ivermectin for COVID-19 were published by 1,030 scientists, reporting the cases of 135,554 patients in 27 countries. These studies show a statistically significant improvement in mortality, ventilation, ICU, hospitalization, recovery, cases, and viral clearance. Specifically, improvements recorded were 85%, 62%, and 43% for prophylaxis, early, and late treatment, with confidence intervals (CI) [77-90%], [51-70%], [28-54%] respectively. A 56% improvement was recorded in the 45 randomized controlled trials (RCTs) with CI [41-68%]. A 51% lower mortality was evidenced from 49 studies with CI [37-61%]. In February 2021, when the war on Ivermectin started in the West, it was clear that this drug had positive effects, working in-vivo/in-vitro, and delivering mostly positive results in clinical trials. More widespread use of Ivermectin could have saved many people, and suppression of this drug in many countries that had very high cumulative fatalities per million people has been a very unfortunate occurrence for science.
摘要:本文综述了伊维菌素治疗COVID-19感染的相关文献。目前,已有204篇论文发表,介绍了使用伊维菌素治疗COVID-19的结果。156项是同行评议,96项是比较治疗组和对照组。22个国家(包括非政府医疗组织在内的39个国家)全部或部分采用伊维菌素进行早期治疗。1030名科学家发表了96项关于伊维菌素治疗COVID-19的研究,报告了27个国家135554名患者的病例。这些研究显示在死亡率、通气、ICU、住院、康复、病例和病毒清除率方面有统计学意义的改善。具体而言,记录的预防、早期和晚期治疗的改善分别为85%、62%和43%,置信区间(CI)分别为[77-90%]、[51-70%]、[28-54%]。在45个随机对照试验(RCTs)中,有56%的改善,CI[41-68%]。49项CI研究[37-61%]证明死亡率降低51%。2021年2月,当针对伊维菌素的战争在西方开始时,很明显这种药物具有积极作用,在体内/体外起作用,并在临床试验中取得了积极的结果。更广泛地使用伊维菌素本可以挽救许多人的生命,而在许多每百万人累积死亡率很高的国家,抑制这种药物对科学来说是非常不幸的事情。
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引用次数: 0
Organocatalyzed Synthesis of Anti-tubercular Agents 抗结核药物的有机催化合成
IF 1.1 Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-09-01 DOI: 10.2174/2213337210666230901141841
Sunil Sharma, Kavita Singh, Rakhi Yadav, Ramesh Kumar, Ram Sagar
This review highlights synthetic developments of anti-tubercular agents by using organocatalysts. Organocatalysts-mediated synthesis is environmentally benign and highly compatible with aqueous-solvent systems, and such catalysts are attractive because of their inexpensive cost, low toxicity, good air and moisture stability and follow many principles of green chemistry. Numerous anti-tuberculosis agents have been synthesized utilizing organocatalysts and tested for their in-vivo and in-vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv pathogens. The inhibitory concentrations of the reported compounds were compared with the standard reference drugs in order to evaluate their inhibition potency.
本文综述了利用有机催化剂合成抗结核药物的研究进展。有机催化剂介导的合成对环境无害,与水-溶剂体系高度相容,这种催化剂因其成本低廉、毒性低、空气和水分稳定性好以及遵循绿色化学的许多原则而受到欢迎。利用有机催化剂合成了许多抗结核药物,并测试了它们对结核分枝杆菌H37Rv病原体的体内和体外抗分枝杆菌活性。将所报道化合物的抑菌浓度与标准对照药物进行比较,评价其抑菌效力。
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引用次数: 0
Greener Approaches to Heterocyclic Compounds 杂环化合物的绿色方法
Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-09-01 DOI: 10.2174/221333721003231023113446
Devalina Ray
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引用次数: 0
The Molecular Structural Analysis of Biologically Important Catechol Molecule: An Integrative Perspective from Experiments and Futuristic Tools 生物学上重要的儿茶酚分子的分子结构分析:从实验和未来工具的综合视角
IF 1.1 Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-09-01 DOI: 10.2174/2213337210666230901161332
M. A. Mir, Kim Andrews, Mohammad Waqar Ashraf, Anuj Kumar, Dharmendra Kumar, Anita Bisht, Reeta Chauhan, Shailendra Prakash
Catechol is a phenolic molecule found naturally in plants. It is also known as pyrogallic acid or 1, 2-dihydroxybenzene. Catechol is currently produced commercially by decarboxylating gallic acid at high temperatures and pressures.This research aimed to understand the biological importance of catechol and perform molecular structural analysis on catechol molecules.Catechol (1, 2, dihydroxy benzene) was studied via computational analysis by employing the use of DFT and B3LYP methods. Hirshfeld analysis was carried out to investigate crystal intermolecular interactions, and the NBO study was performed to study chemical donating and accepting interactions. Moreover, the computational study was performed using FTIR, HNMR and other instrumentation like AIM theory for circular dichroism data.Furthermore, the surface iso-projection study and binding energy results did prove to run in alignment with experimentally obtained values from the computational studies. Fukui functional study and molecular electrostatic potential were utilized in the study to investigate interactions between anionic and cationic sites of catechol. In addition, molecular dynamic simulations revealed that biomolecular stability was also present. Thus, the antibiotic efficacy of catechol displayed chemical oxidative interactions that exhibited close chemical correlations with ascorbic acid, ellagic acid, and gallic acid.The catechol has been examined experimentally and theoretically. The results were compared with catechol spectra, including IR and UV-visible spectra generated through computer analysis. The experimentally observed spectra were found to be in parallel with theoretical data. According to drug-likeness investigations, the following compounds, gallic acid, ellagic acid, and ascorbic acid, were found to be closely related to catechol as an antibiotic. Hence, it can be concluded that catechol, whether in its entirety or in a portion, is a potent antibacterial, anti-inflammatory, and anti-malarial drug.
儿茶酚是一种天然存在于植物中的酚类分子。它也被称为焦没食子酸或1,2-二羟基苯。邻苯二酚目前是通过在高温高压下使没食子酸脱羧而在商业上生产的。本研究旨在了解儿茶酚的生物学重要性,并对儿茶酚分子进行分子结构分析。采用DFT和B3LYP方法对邻苯二酚(1,2-二羟基苯)进行了计算分析。Hirshfeld分析用于研究晶体分子间的相互作用,NBO研究用于研究化学供体和受体的相互作用。此外,使用FTIR、HNMR和其他仪器(如AIM理论)对圆二色性数据进行了计算研究。此外,表面等投影研究和结合能结果确实与计算研究中实验获得的值一致。利用Fukui功能研究和分子静电势研究了邻苯二酚阴离子和阳离子位点之间的相互作用。此外,分子动力学模拟表明,还存在生物分子稳定性。因此,邻苯二酚的抗生素功效表现出与抗坏血酸、鞣花酸和没食子酸密切化学相关性的化学氧化相互作用。对邻苯二酚进行了实验和理论研究。将结果与邻苯二酚光谱进行了比较,包括通过计算机分析产生的红外光谱和紫外可见光谱。实验观察到的光谱与理论数据是平行的。根据药物相似性研究,发现以下化合物,没食子酸、鞣花酸和抗坏血酸,与邻苯二酚作为抗生素密切相关。因此,可以得出结论,邻苯二酚,无论是全部还是部分,都是一种强效的抗菌、抗炎和抗疟疾药物。
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引用次数: 0
Molecular Dynamic, Hirshfeld Surface, Computational Quantum and Spectroscopic analysis of 4-Hydroxy-1-Naphthaldehyde 4-羟基-1-萘醛的分子动力学,Hirshfeld表面,计算量子和光谱分析
IF 1.1 Q4 CHEMISTRY, PHYSICAL Pub Date : 2023-08-16 DOI: 10.2174/2213337210666230816091246
M. Mir, M. Jassal, K. Andrews
Computational Quantum and Spectroscopic analysis of 4-Hydroxy-1-NaphthaldehydeKnown also as 4-Hydroxynaphthalene-1-carbaldehyde, 4-hydroxy-1-naphthaldehyde (4H1NA) is a crucial precursor of many coordinating agents. A commercial compound called 4-hydroxy-1-naphthaldehyde (4H1NA) can be used to make a number of different sensors. In the development of many chemosensors, they operate effectively as a functionalized fluorescent backbone.Molecular Dynamic, Hirshfeld Surface, Computational Quantum analysis of Naphthaldehyde.The methods employed in the analysis of the compound involve the DFT calculations, using DFT method and B3LYP/6-311++G (d, p) basis set with respect to its FTIR, NMR, and UV-Visible spectrum. The NMR chemical shifts of carbon and protons in CDCl3 was determined by GIAO method. For the molecule of reference, HOMO-LUMO and Donor-Acceptor interactions were also taken into consideration. Investigations also looked into ELF, Fukui activity, and nonlinear optical properties.The investigation of the compound at its atomic level was analysed using the computational methods so that chemical, medicinal, and environmental research make use of them to make the molecule more in an improved form with distinguished properties. Strong interaction has been produced as a result of electron transfer from the oxygen atoms lone pair LP (2) to the anti-bonding orbital *(C3-C5) with a significant stabilization energy of 42.61kcal/mol. The attributes of the NLO molecule were calculated and found to be superior to those of the urea molecule, with linear and first order hyper polarizability situation. Our findings imply that the reference molecule can be a heavier contender for NLO as a surface material and could be considered as a vital substance for medicine purpose in the drug industry due to its maximum electrophilicity index.A commercial compound called 4-hydroxy-1-naphthaldehyde (4H1NA) can be used to make a number of different sensors. The compound has good structural and optical properties. They can be employed for a variety of optical limiting applications because of their unusual optical characteristic, which exhibits third-order nonlinear behavior.
4-羟基-1-萘醛(4 -羟基-1-萘醛,4H1NA)是许多配位剂的重要前体。一种叫做4-羟基-1-萘醛(4H1NA)的商业化合物可以用来制造许多不同的传感器。在许多化学传感器的发展中,它们作为一种功能化的荧光骨架有效地发挥作用。分子动力学,赫斯菲尔德表面,萘醛的计算量子分析。化合物的分析方法包括DFT计算,使用DFT方法和B3LYP/6-311++G (d, p)基集对其FTIR、NMR和uv -可见光谱进行分析。用GIAO法测定了CDCl3中碳和质子的核磁共振化学位移。作为参比分子,还考虑了HOMO-LUMO和供体-受体相互作用。调查还研究了ELF、福井活动和非线性光学性质。在原子水平上对化合物的研究使用计算方法进行了分析,以便化学、医学和环境研究利用它们使分子更加具有改进的形式和独特的性质。氧原子孤对LP(2)向反键轨道*(C3-C5)转移电子产生了强相互作用,稳定能达到42.61kcal/mol。计算了NLO分子的性质,发现NLO分子的性质优于尿素分子,具有线性和一阶超极化情况。我们的研究结果表明,参考分子可以成为NLO作为表面材料的更有力的竞争者,并且由于其最大的亲电性指数,可以被认为是制药工业中用于医学目的的重要物质。一种叫做4-羟基-1-萘醛(4H1NA)的商业化合物可以用来制造许多不同的传感器。该化合物具有良好的结构性能和光学性能。由于其独特的光学特性,具有三阶非线性特性,可用于各种光学限制应用。
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Current Organocatalysis
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