Research progress of long-wavelength light-triggered photodynamic therapy for malignant tumor treatment

国际生物医学工程杂志 Pub Date : 2019-04-28 DOI:10.3760/CMA.J.ISSN.1673-4181.2019.02.017

Jiayan Zhou

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Abstract

Malignant tumor is one of the most deadly diseases in the world. Researches focus on finding tumor therapy with better therapeutic efficiency and fewer side effects. Improving the therapeutic effect and reducing the side effects are the two hot topics in the field of malignant tumors treatment. As one of the new methods for non-invasive treatment of malignant tumors, photodynamic therapy (PDT) has the advantage of low cytoxicity and low drug resistance. PDT induces reactive oxygen species (ROS) production by irradiating light to specific sites, causing tumor cell apoptosis and necrosis, and achieving therapeutic purposes. Compared with the traditional PDT, long-wavelength light-triggered photodynamic therapy has deep tissue penetration and less cytoxicity. In this paper, the technical development of the long-wavelength light-triggered PDT was summarized including photosensitizers, two-photon activated PDT and upconversion PDT. The research progress of this therapeutic method in the treatment of malignant tumors was also reviewed. Key words: Tumor; Photodynamic therapy; Long-wavelength light; Nanomaterial

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长波光触发光动力疗法治疗恶性肿瘤的研究进展

恶性肿瘤是世界上最致命的疾病之一。研究的重点是寻找疗效更好、副作用更小的肿瘤治疗方法。提高治疗效果和减少不良反应是恶性肿瘤治疗领域的两大热点。光动力疗法(PDT)作为恶性肿瘤无创治疗的新方法之一，具有低细胞毒性和低耐药性的优点。PDT通过将光照射到特定部位，诱导活性氧(ROS)的产生，引起肿瘤细胞凋亡和坏死，达到治疗目的。与传统的PDT相比，长波光触发光动力疗法具有较深的组织穿透性和较小的细胞毒性。本文综述了长波光触发PDT的技术进展，包括光敏剂、双光子激活PDT和上转换PDT。综述了该治疗方法在恶性肿瘤治疗中的研究进展。关键词:肿瘤;光动力治疗;长波长光;纳米材料

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