The Effect of Central Sensitization on Postoperative Neurocognitive Dysfunction in Hospitalized Elderly Patients: A Prospective Cohort Clinical Trial.

IF 1.4 4区医学 Q4 GERIATRICS & GERONTOLOGY Experimental Aging Research Pub Date : 2024-03-01 Epub Date: 2023-02-22 DOI:10.1080/0361073X.2023.2182093

Lili Yu, Dongliang Yang, Qi Zhou, Chunping Yin, Qi Zhang, Wei Li, Jiaxu Yu, Qiujun Wang

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引用次数: 0

Abstract

Objective: To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD).

Methods: One hundred and thirty-three aged patients undergoing total knee arthroplasty (TKA) who received femoral nerve block and general anesthesia were recruited in this research and prospectively assigned into two groups according to the Central Sensitization Inventory (CSI) score: group C (n = 106, CSI score less than 40) and group CS (n = 27, CSI score higher than 40). Scores of Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM), Numerical Rating Scale (NRS) and Quality of recovery-40 (QoR-40) questionnaires were assessed. Basic information and clinical records of all participants were also collected.

Results: PNCD occurred in 24 (22.6%) of patients in group C and 16 (59.3%) in group CS (p < .05). Multivariate logistic regression analysis revealed that patients with CSI score ≥40 before surgery exhibited higher risk of PNCD after adjustment for other risk factors (p < .05). Compared to group C, the pre- and post-operative NRS scores, pain duration, the WOMAC score, and propofol consumptions for anesthesia induction were significantly increased in group CS (p < .05).

Conclusion: Hospitalized elderly patients with clinical symptoms of CS scores may have increased risk of PNCD following TKA.

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中枢增敏对住院老年患者术后神经认知功能障碍的影响：一项前瞻性队列临床试验

目的研究老年患者的中枢敏感化（CS）是否是术后神经认知功能障碍（PNCD）的预测风险因素：本研究招募了133名接受股神经阻滞和全身麻醉的老年全膝关节置换术（TKA）患者，并根据中枢敏感性量表（CSI）评分前瞻性地将其分为两组：C组（106人，CSI评分低于40分）和CS组（27人，CSI评分高于40分）。对蒙特利尔认知评估（MoCA）、迷你精神状态检查（MMSE）、混淆评估法（CAM）、数字评定量表（NRS）和康复质量-40（QoR-40）问卷的得分进行了评估。此外，还收集了所有参与者的基本信息和临床记录：结果：C 组有 24 名患者（22.6%）发生了 PNCD，CS 组有 16 名患者（59.3%）发生了 PNCD（P P P 结论：C 组和 CS 组的 PNCD 发生率分别为 22.6%和 59.3%：有 CS 评分临床症状的住院老年患者在 TKA 术后发生 PNCD 的风险可能会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Aging Research 医学-老年医学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.