Experimental Aging Research最新文献

Objective: Cognitive dysfunction is a significant issue in old age and can cause many problems in older adults, especially those with diabetes. This study aimed to investigate the association between oral health status and DMFT index with cognitive dysfunction in community-dwelling older adults with T2D (type 2 diabetes).

Methods: This was a cross-sectional study that included 245 older people aged 60 years and older with T2D, visiting healthcare centers in north of Iran, using the cluster sampling method. Data collection tools included clinical-demographic questionnaire, the Geriatric Oral Health Assessment Index (GOHAI) and the Mini-Mental State Examination (MMSE) questionnaire. A P-value <.05 was considered significant.

Results: The mean age of older adults in this study was 64.86 ± 3.99 years. The mean and standard deviation for the DMFT index, GOHAI index and MMSE scale were 9.39 ± 3.83, 34.29 ± 17.93 and 15.18 ± 10.04 respectively. The results showed statistically significant relationship between poor oral health status and the cognitive status of older adults with T2D (p < .001). Additionally, the relationship between oral health index domains (physical function, psychosocial function and pain) and cognitive status in older adults was significant (p < .001). Another finding indicated an inverse and significant relationship between the DMFT index and cognitive dysfunction in older adults (p < .001).

Conclusion: Poor oral health was associated with cognitive dysfunction among the community-dwelling older adults with T2D. Given the high prevalence of T2D in older adults and the critical importance of oral and dental health for cognition, it is necessary to develop interventions to improve oral health in older adults with T2D.

This study examined the combined influence of assimilation and contrast effects on the memory self-efficacy and objective memory of young (ages 18-25, n = 114), middle-age (ages 26-59, n = 48), and older (ages 60-98, n = 59) adults. We reminded participants that they matched positive, not negative, memory-relevant or memory-irrelevant stereotypes of aging either before (experimental conditions) or after (control condition) they completed a memory self-efficacy questionnaire and took a memory test. Participants exposed to memory-relevant aging stereotypes prior to other measures reported higher memory self-efficacy than those exposed to memory-irrelevant stereotypes; this effect did not depend on age group. In contrast, the effect of stereotype exposure on memory performance differed with age. Young and older, but not middle-aged, adults showed differences in their memory scores depending on whether they were exposed to memory-relevant, memory-irrelevant or no aging stereotypes. In general, exposure to stereotypes (particularly those relevant to memory) had a negative influence on memory that contrasted with its positive effect on memory self-efficacy. Together, these results indicate that exposure to aging stereotypes can have opposing effects on the memory self-efficacy and objective test performance of adults of various ages and that the relevance of the stereotypes to the cognitive domain being assessed matters.

Background: The present study examined age differences in and the relationship between two indices of cognitive reappraisal and expressive suppression: the degree of emotion regulation and the habitual use of emotion-regulation strategies.

Method: In total, 101 younger and 99 older participants were included in this study. The degree of emotion regulation was measured using an experimental task in which participants were presented with negative or positive pictures and required to regulate their emotions. Habitual use of emotion regulation strategies was measured using an emotion regulation questionnaire.

Results: The results showed that younger adults regulated their emotions to a greater extent than older adults in both reappraisal and suppression. Younger adults were more likely to use reappraisal than were older adults, although there were no age differences in the use of suppression. No significant correlations were found between the degree of emotion regulation and the habitual use of emotion regulation strategies.

Conclusion: These results suggest that age differences in emotion regulation depend on the regulation strategy and that the degree of emotion regulation and habitual use of emotion regulation strategies are independent and quite different indicators in nature.

The aim was to examine the diagnostic efficacy of hippocampal subregions volume and texture in differentiating amnestic mild cognitive impairment (MCI) from normal aging changes. Ninety MCI subjects and eighty-eight well-matched healthy controls (HCs) were selected. Twelve hippocampal subregions volume and texture features were extracted using Freesurfer and MaZda based on T1 weighted MRI. Then, two-sample t-test and Least Absolute Shrinkage and Selection Operator (LASSO) regression were developed to select a subset of the original features. Support vector machine (SVM) was used to perform the classification task and the area under the curve (AUC), sensitivity, specificity and accuracy were calculated to evaluate the diagnostic efficacy of the model. The volume features with high discriminative power were mainly located in the bilateral CA1 and CA4, while texture feature were gray-level non-uniformity, run length non-uniformity and fraction. Our model based on hippocampal subregions volume and texture features achieved better classification performance with an AUC of 0.90. The volume and texture of hippocampal subregions can be utilized for the diagnosis of MCI. Moreover, we found that the features that contributed most to the model were mainly textural features, followed by volume. These results may guide future studies using structural scans to classify patients with MCI.

This study examined the effectiveness of a multiple group membership intervention for reducing the negative effects of age-based stereotype threat (ABST) on older adults' objective memory performance and subjective memory concerns. Healthy older adults (N = 68) were randomly allocated to an ABST + threat-removal (ABST+TR) or ABST + active-control (ABST+AC) condition. After activating ABST, the ABST+TR condition completed a group-listing task and the ABST+AC condition completed a meal-listing task. Participants then completed the Rey Auditory Verbal Learning Test (RAVLT) and Everyday Memory Questionnaire - Revised. One significant difference was found in memory performance between conditions; specifically, after controlling for age, gender, and number of items listed, those in the ABST+TR condition performed significantly better on the RAVLT memory interference trial. Further, listing a greater number of group memberships was associated with better memory performance in the ABST+TR condition. No significant difference was found in subjective memory concerns between the ABST+TR condition and the ABST+AC condition. Overall, the current findings indicated that raising the salience of multiple group memberships offered limited protection for older adults' cognitive test performance in the context of ABST.

Introduction: This study aimed to evaluate the modifying role of dietary fiber intake in the relationship between COPD and cognitive performance.

Methods: Data of adults aged ≥60 years were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Participants with information on cognitive function measures were included. Dietary fiber intake, identified using participants' 24-h recall surveys, was grouped into high (>25 g/day) and low (≤25 g/day) levels. COPD was identified through self-reported physician diagnoses. Associations between dietary fiber intake, cognitive function and COPD were evaluated using the regression analysis.

Results: Data of 2,189 participants were analyzed. Multivariate analysis revealed that COPD was significantly associated with lowered CERAD (adjusted beta [aBeta]: -0.17, 95% confidence interval [CI]: -0.33 to -0.002, p = .047) and DSST (aBeta: -2.23, 95% CI: -4.25 to -0.2, p = .032) scores in older adults. The analysis on the association between COPD and cognitive function stratified by dietary fiber intake revealed that COPD remained significantly associated with lowered CREAD among individuals with a high fiber intake (aBeta: -0.54, 95% CI: -1.00 to -0.08, p = .024).

Conclusions: In US older adults, COPD is associated with reduced cognitive function. However, the findings do not support that high dietary fiber intake may modify the association between COPD and cognitive impairment.

Objective: The current study aimed to examine the relationship between depressive symptoms and quality of life among Jordanian community-dwelling older adults.

Methods: A cross-sectional, descriptive correlational design was used. A convenience sample (N = 602) was selected to recruit the participants in the Amman governorate during the period from August to November 2021.

Results: Findings demonstrated that the mean (SD) age of older adults was 67.5 (7.0) years and 51.5% of participants were females. Also, 54.1% of the participants experienced moderate to severe depressive symptoms with a total mean (SD) score was 8.57 on a scale of 0 to 15, while the mean (SD) for the quality of life scale was 12.12 (3.85) on a scale of 4 to 20. Significant differences existed in quality of life and depressive symptoms based on marital status (p < .001), educational level (p < .001), working status (p < .01), income (p < .001), and chronic disease (p < .01). Quality of life and its domains were negatively associated with depressive symptoms (B= - 0.596, p < .001). Also, marital status, working, educational level, income, and chronic disease were associated with depressive symptoms.

Conclusion: Strategies to improve quality of life should be promoted to minimize depressive symptoms among older adults and consider significant demographic factors.

A sudden turn initiated at an unpredictable moment is referred to as reactive turning. This study was designed to seek an age-related decrease in reactive turning when the task demand for turning was increased using a task-switching paradigm. Twenty healthy older adults and 14 younger adults were instructed to walk and execute a 90-degree turn under two conditions. In the "reactive turning condition," participants were asked to turn abruptly when the initially presented travel direction (e.g. right) switched to the opposite direction (e.g. left) while walking. This switch occurred in only one-fifth of 40 trials. In the "pre-planned turning condition," participants were informed of the direction beforehand. The onset of the center of mass (COM) shift in older participants failed to reach significance compared to younger participants. However, correlation analyses showed impaired turning performance in older participants, as those with delayed COM shift exhibited larger pelvic rotations over a short period during reactive turning. This suggests that, owing to increased task demand, older adults had difficulty quickly responding and sufficiently rotating their bodies in the new direction. We conclude that reactive turning with increased task demand, using a task-switching paradigm, is a key factor in detecting age-related performance decline.

Background/study context: Research on older adults has shown impairments in nocturnal sleep, impacting motor memory consolidation and learning. However, previous studies primarily focus on simple tasks, limiting generalization to complex motor activities. Moreover, no evidence exists on how sleep influences adaptability and relearning in older adults.

Methods: Sixty older adults and 60 young adults practiced an underarm dart-throwing task. The participants were divided into 2 sub-groups: SLEEP, which practiced in the evening and was retested on the morning of the following day, and CONTROL, which practiced in the morning and was retested in the evening on the same day. The practice and retention phases were spaced 12 hours. We analyzed motor learning through persistence, adaptability and relearning rate.

Results: Sleep did not enhance motor learning for any group. While young adults exhibited retention, older adults did not, especially after nocturnal sleep. There was no difference between sub-groups in adaptability. Older adults demonstrated inferior relearning compared to young adults, independently of sleep.

Conclusion: Nocturnal sleep did not influence memory consolidation in any group. On the contrary, our findings suggest that nocturnal sleep harms retention in older adults. Age-related characteristics induce a worse relearning rate regardless of sleep occurrence.