The perivascular niche of endometrial mesenchymal stromal/stem-like cells

IF 0.7 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Reproductive and Developmental Medicine Pub Date : 2022-09-21 DOI:10.1097/RD9.0000000000000038
R. Chan, Tian-Qi Li, Sisi Zhang, Yuan Fang, Jingxuan Xu
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Abstract

Human endometrium is a unique adult tissue that undergoes cyclical shedding, repair, and regeneration during a woman’s reproductive life. Over the past 2 decades, tremendous progress has been made towards the identification and characterization of endometrial stromal stem/progenitor cells . The substantial regeneration of vascularized stroma in the endometrium during the proliferative stages of each menstrual cycle is likely to be mediated by endometrial mesenchymal stromal/stem cells. This review focuses on the perivascular niche for CD140b+CD146+ pericytes and SUSD2+ perivascular cells. The identity, characteristics, and underlying mechanisms of uterine regeneration are also discussed.
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子宫内膜间充质基质/干细胞样细胞的血管周围生态位
人类子宫内膜是一种独特的成年组织,在女性的生殖生活中经历周期性脱落、修复和再生。在过去的20年里,在子宫内膜基质干/祖细胞的鉴定和表征方面取得了巨大进展。在每个月经周期的增殖阶段,子宫内膜血管化基质的实质性再生可能是由子宫内膜间充质基质/干细胞介导的。这篇综述的重点是CD140b+CD146+周细胞和SUSD2+血管周围细胞的血管周围小生境。还讨论了子宫再生的特性、特征和潜在机制。
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来源期刊
Reproductive and Developmental Medicine
Reproductive and Developmental Medicine OBSTETRICS & GYNECOLOGY-
CiteScore
1.60
自引率
12.50%
发文量
384
审稿时长
23 weeks
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