Pub Date : 2024-12-01Epub Date: 2024-09-06DOI: 10.1097/RD9.0000000000000109
Zidao Wang, Yuehuan Li, Christian L Andersen, Ahmed E El Zowalaty, Jonathan M Hancock, Taylor E Martin, Elizabeth W Howerth, Suvitha Viswanathan, Haeyeun Byun, Xiaoqin Ye
Objective: Female Mcoln1-/- mice exhibit progressive progesterone (P4) deficiency, luteal cell degeneration, and premature embryo implantation failure at 5 months old. We attempted to rescue embryo implantation in non-virgin Mcoln1-/- mice (5-6 months old) with exogenous P4 treatment on days 1.5 post-coitum (D1.5), D2.5, and D3.5, and observed partially restored luteal cell morphology on D4.5, but unexpectedly found 17β-estradiol (E2) contamination in the P4 working solution. In this study, we aim to investigate exogenous P4 and/or E2 for the partial recovery of luteal cell morphology in infertile Mcoln1-/- mice.
Methods: Control and non-virgin Mcoln1-/- mice (5-6 months old) were treated with newly ordered vehicle, P4, E2, or P4 + E2 on D1.5 and D2.5 and dissected on D3.5 for P4 and E2 measurements, ovary histology, immunofluorescence, lipid droplet staining, and transmission electron microscopy.
Results: E2 treatment significantly increased serum P4 levels in D3.5 Mcoln1-/- mice. E2 and P4 + E2 treatments, but not P4 treatment alone, largely improved the morphology of D3.5 Mcoln1-/- corpora lutea, indicated by a more contiguous web-like collagen IV expression pattern, increased heat shock protein 60 expression, and reduced accumulation of large lipid droplets. Transmission electron microscopy revealed extremely enlarged autophagosomes and lipid droplets, lysosomes with lamellar structures, and mitochondria with reduced cristae in vehicle-treated D3.5 Mcoln1-/- luteal cells, while in E2-treated D3.5 Mcoln1-/- luteal cells, extremely enlarged autophagosomes and lipid droplets were reduced, indicating improved luteal cell ultrastructure.
Conclusion: These findings reveal protective effects of high levels of exogenous E2 on P4 production and lysosomal function in Mcoln1-/- luteal cells.
{"title":"Exogenous estrogen partially rescues progesterone deficiency and autophagosome enlargement in <i>Mcoln1</i> <sup>-/-</sup> mouse model with lysosomal storage disorder.","authors":"Zidao Wang, Yuehuan Li, Christian L Andersen, Ahmed E El Zowalaty, Jonathan M Hancock, Taylor E Martin, Elizabeth W Howerth, Suvitha Viswanathan, Haeyeun Byun, Xiaoqin Ye","doi":"10.1097/RD9.0000000000000109","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000109","url":null,"abstract":"<p><strong>Objective: </strong>Female <i>Mcoln1</i> <sup>-/-</sup> mice exhibit progressive progesterone (P4) deficiency, luteal cell degeneration, and premature embryo implantation failure at 5 months old. We attempted to rescue embryo implantation in non-virgin <i>Mcoln1</i> <sup>-/-</sup> mice (5-6 months old) with exogenous P4 treatment on days 1.5 post-coitum (D1.5), D2.5, and D3.5, and observed partially restored luteal cell morphology on D4.5, but unexpectedly found 17β-estradiol (E<sub>2</sub>) contamination in the P4 working solution. In this study, we aim to investigate exogenous P4 and/or E<sub>2</sub> for the partial recovery of luteal cell morphology in infertile <i>Mcoln1</i> <sup><i>-/-</i></sup> mice.</p><p><strong>Methods: </strong>Control and non-virgin <i>Mcoln1</i> <sup>-/-</sup> mice (5-6 months old) were treated with newly ordered vehicle, P4, E<sub>2</sub>, or P4 + E<sub>2</sub> on D1.5 and D2.5 and dissected on D3.5 for P4 and E<sub>2</sub> measurements, ovary histology, immunofluorescence, lipid droplet staining, and transmission electron microscopy.</p><p><strong>Results: </strong>E<sub>2</sub> treatment significantly increased serum P4 levels in D3.5 <i>Mcoln1</i> <sup>-/-</sup> mice. E<sub>2</sub> and P4 + E<sub>2</sub> treatments, but not P4 treatment alone, largely improved the morphology of D3.5 <i>Mcoln1</i> <sup>-/-</sup> corpora lutea, indicated by a more contiguous web-like collagen IV expression pattern, increased heat shock protein 60 expression, and reduced accumulation of large lipid droplets. Transmission electron microscopy revealed extremely enlarged autophagosomes and lipid droplets, lysosomes with lamellar structures, and mitochondria with reduced cristae in vehicle-treated D3.5 <i>Mcoln1</i> <sup>-/-</sup> luteal cells, while in E<sub>2</sub>-treated D3.5 <i>Mcoln1</i> <sup>-/-</sup> luteal cells, extremely enlarged autophagosomes and lipid droplets were reduced, indicating improved luteal cell ultrastructure.</p><p><strong>Conclusion: </strong>These findings reveal protective effects of high levels of exogenous E<sub>2</sub> on P4 production and lysosomal function in <i>Mcoln1</i> <sup>-/-</sup> luteal cells.</p>","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"8 4","pages":"197-205"},"PeriodicalIF":0.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-20DOI: 10.1097/rd9.0000000000000083
Aidana Begaidarova, S. Baikoshkarova, Botakoz Mutaliyeva
The purpose of this study is to investigate the influence of the biochemical composition of human native ejaculate on the preservation of male gamete activity after the application of cryopreservation technology, and to evaluate the potential practical application of these findings in future fertilization processes. The methodology employed in this study involves a systematic analysis of the technological aspects of cryopreserving human semen, coupled with an analytical examination of how the biochemical composition of semen affects the preservation of male gamete activity. The results of the study demonstrate a clear relationship between the activity of male gametes and changes in the biochemical composition of semen following cryopreservation. This study addresses the issue of male infertility in Kazakhstan and underscores the importance of research in embryology and reproductive medicine to effectively address this problem.
{"title":"Study of the influence of the biochemical composition of the human native ejaculate on the preservation of the male gametes’ activity after the application of cryopreservation technology","authors":"Aidana Begaidarova, S. Baikoshkarova, Botakoz Mutaliyeva","doi":"10.1097/rd9.0000000000000083","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000083","url":null,"abstract":"\u0000 \u0000 The purpose of this study is to investigate the influence of the biochemical composition of human native ejaculate on the preservation of male gamete activity after the application of cryopreservation technology, and to evaluate the potential practical application of these findings in future fertilization processes.\u0000 \u0000 \u0000 \u0000 The methodology employed in this study involves a systematic analysis of the technological aspects of cryopreserving human semen, coupled with an analytical examination of how the biochemical composition of semen affects the preservation of male gamete activity.\u0000 \u0000 \u0000 \u0000 The results of the study demonstrate a clear relationship between the activity of male gametes and changes in the biochemical composition of semen following cryopreservation.\u0000 \u0000 \u0000 \u0000 This study addresses the issue of male infertility in Kazakhstan and underscores the importance of research in embryology and reproductive medicine to effectively address this problem.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61786366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-17DOI: 10.1097/rd9.0000000000000082
Manish Kumar, Luhan Jiang, Hoi-Lam Lai, Cheuk-Lun Lee, E. Ng, W. Yeung, Kai-Fai Lee
The uterus was previously considered a sterile environment for embryo implantation and fetal growth; however, evidence showed that different microorganisms in the female reproductive tract may regulate human fertility. The Lactobacillus family is among the most prevalent bacteria in the vagina and uterus of the female reproductive system. Interestingly, a Lactobacillus-dominated (LD) uterine environment is associated with better pregnancy outcomes. Nevertheless, the mechanism by which an LD environment improves pregnancy outcomes is unknown. In the uterus, many commensal bacteria (e.g., Bifidobacterium, Prevotella, Enterobacter, Streptococcus, and Staphylococcus) produce short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate. SCFAs are crucial in modulating cytokine production (e.g., IL-6 and IL-10) and immune cell populations (e.g., T cells and macrophages) during embryo implantation and gynecological diseases. This minireview provides an overview of the roles of Lactobacilli and SCFAs in female fertility and related diseases.
{"title":"Impact of Microbiota on Female Fertility and Gynecological problems","authors":"Manish Kumar, Luhan Jiang, Hoi-Lam Lai, Cheuk-Lun Lee, E. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000082","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000082","url":null,"abstract":"The uterus was previously considered a sterile environment for embryo implantation and fetal growth; however, evidence showed that different microorganisms in the female reproductive tract may regulate human fertility. The Lactobacillus family is among the most prevalent bacteria in the vagina and uterus of the female reproductive system. Interestingly, a Lactobacillus-dominated (LD) uterine environment is associated with better pregnancy outcomes. Nevertheless, the mechanism by which an LD environment improves pregnancy outcomes is unknown. In the uterus, many commensal bacteria (e.g., Bifidobacterium, Prevotella, Enterobacter, Streptococcus, and Staphylococcus) produce short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate. SCFAs are crucial in modulating cytokine production (e.g., IL-6 and IL-10) and immune cell populations (e.g., T cells and macrophages) during embryo implantation and gynecological diseases. This minireview provides an overview of the roles of Lactobacilli and SCFAs in female fertility and related diseases.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46226047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-14DOI: 10.1097/rd9.0000000000000080
L. Jia, Pei-Gen Chen, Lin Chen, C. Fang, Jing Zhang, Panyu Chen
To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with nonobstructive azoospermia (NOA) decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction (mTESE). A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection (ICSI): the fresh and cryopreserved groups. After evaluating several machine learning algorithms, logistic regression was selected. Using LASSO regression and 10-fold cross-validation, the factors associated with clinical pregnancy were analyzed. The area under the curves (AUCs) for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759, respectively. Compared with various modeling algorithms, Logistic Regression outperformed machine learning in both groups, with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved group. The model accurately predicted clinical pregnancies in NOA couples.
{"title":"Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study","authors":"L. Jia, Pei-Gen Chen, Lin Chen, C. Fang, Jing Zhang, Panyu Chen","doi":"10.1097/rd9.0000000000000080","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000080","url":null,"abstract":"\u0000 \u0000 To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with nonobstructive azoospermia (NOA) decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction (mTESE).\u0000 \u0000 \u0000 \u0000 A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection (ICSI): the fresh and cryopreserved groups. After evaluating several machine learning algorithms, logistic regression was selected. Using LASSO regression and 10-fold cross-validation, the factors associated with clinical pregnancy were analyzed.\u0000 \u0000 \u0000 \u0000 The area under the curves (AUCs) for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759, respectively. Compared with various modeling algorithms, Logistic Regression outperformed machine learning in both groups, with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved group.\u0000 \u0000 \u0000 \u0000 The model accurately predicted clinical pregnancies in NOA couples.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42135755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-14DOI: 10.1097/rd9.0000000000000081
Xiaoyin Yuan, Y. Wang, Haiyan Yang, Bin Zhao
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. This study aimed to use text mining and microarray data analysis to identify drugs that target genes and potential pathways associated with PCOS. We extracted a common set of genes associated with PCOS using text mining and the microarray dataset GSE48301. Next, we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these genes, as well as protein-protein interaction (PPI) network analysis. Additionally, we used MCODE and cytoHubba to cluster significant common genes in the PPI network and performed gene-drug interaction analyses to identify potential drugs for further investigation. Finally, we annotated pathways associated with the genes identified. Text mining and microarray analysis yielded 696 text mining genes (TMGs) and 2,804 differentially expressed genes (DEGs). Among these, a set of 77 genes was found in both TMGs and DEGs. Interestingly, 67 of these genes participated in constructing the PPI network. Seven common hub genes were selected using the MCODE and CytoHubba methods. Finally, five out of seven genes were targeted by 15 existing drugs. Four genes (FASLG, IL13, IL17A, and IL2RA), which are mainly related to the cytokine-cytokine receptor interaction pathway, could be prioritized as targets for PCOS.
{"title":"Text mining and data analysis identifies potential drugs and pathways for polycystic ovary syndrome treatment","authors":"Xiaoyin Yuan, Y. Wang, Haiyan Yang, Bin Zhao","doi":"10.1097/rd9.0000000000000081","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000081","url":null,"abstract":"\u0000 \u0000 Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. This study aimed to use text mining and microarray data analysis to identify drugs that target genes and potential pathways associated with PCOS.\u0000 \u0000 \u0000 \u0000 We extracted a common set of genes associated with PCOS using text mining and the microarray dataset GSE48301. Next, we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these genes, as well as protein-protein interaction (PPI) network analysis. Additionally, we used MCODE and cytoHubba to cluster significant common genes in the PPI network and performed gene-drug interaction analyses to identify potential drugs for further investigation. Finally, we annotated pathways associated with the genes identified.\u0000 \u0000 \u0000 \u0000 Text mining and microarray analysis yielded 696 text mining genes (TMGs) and 2,804 differentially expressed genes (DEGs). Among these, a set of 77 genes was found in both TMGs and DEGs. Interestingly, 67 of these genes participated in constructing the PPI network. Seven common hub genes were selected using the MCODE and CytoHubba methods. Finally, five out of seven genes were targeted by 15 existing drugs.\u0000 \u0000 \u0000 \u0000 Four genes (FASLG, IL13, IL17A, and IL2RA), which are mainly related to the cytokine-cytokine receptor interaction pathway, could be prioritized as targets for PCOS.\u0000","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49187380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.1097/rd9.0000000000000079
Dan Mo, Zhonghong Zeng, Xin Sui, Rong Li, Yi-Hua Yang
The female ovaries are critical for follicle growth and development in the process known as “folliculogenesis”. This complex process is regulated by various factors, among which the microenvironment around follicles appears to be crucial. According to previous studies, folliculogenesis is an energy-demanding process. In fact, well-balanced follicular energy metabolism is associated with ovarian function and female fertility. Consequently, glucose metabolism has been widely described as the main source of energy during folliculogenesis. Generally, the follicular glucose metabolism profiles change dynamically during follicular development. Metabolic abnormalities during folliculogenesis are associated with aging, primary ovarian insufficiency, and polycystic ovary syndrome, thereby leading to subfertility and infertility in females. The signaling pathways in follicles appear to form a link between glucose metabolism and folliculogenesis. Therefore, a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental competence. This review aimed to describe variations in glucose metabolism at different stages of folliculogenesis, provide new insights into glucose metabolic disorder-related diseases, and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis: phosphatidylinositol 3-kinase, protein kinase B (PI3K-PKB/AKT) and AMP-activated protein kinase (AMPK) signaling pathways.
{"title":"Role of Glucose Metabolism and Signaling Pathways at Different Stages of Ovarian Folliculogenesis","authors":"Dan Mo, Zhonghong Zeng, Xin Sui, Rong Li, Yi-Hua Yang","doi":"10.1097/rd9.0000000000000079","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000079","url":null,"abstract":"The female ovaries are critical for follicle growth and development in the process known as “folliculogenesis”. This complex process is regulated by various factors, among which the microenvironment around follicles appears to be crucial. According to previous studies, folliculogenesis is an energy-demanding process. In fact, well-balanced follicular energy metabolism is associated with ovarian function and female fertility. Consequently, glucose metabolism has been widely described as the main source of energy during folliculogenesis. Generally, the follicular glucose metabolism profiles change dynamically during follicular development. Metabolic abnormalities during folliculogenesis are associated with aging, primary ovarian insufficiency, and polycystic ovary syndrome, thereby leading to subfertility and infertility in females. The signaling pathways in follicles appear to form a link between glucose metabolism and folliculogenesis. Therefore, a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental competence. This review aimed to describe variations in glucose metabolism at different stages of folliculogenesis, provide new insights into glucose metabolic disorder-related diseases, and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis: phosphatidylinositol 3-kinase, protein kinase B (PI3K-PKB/AKT) and AMP-activated protein kinase (AMPK) signaling pathways.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49164682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.1097/rd9.0000000000000077
M. Mahmoud, Abd Elhalim, M. Ellaban, M. Saleh, Hamdi Mohamed Ali, Khaled M Abdalla, M. Eldeib, Ahmed Ali Faheem, A. Almarghany, M. Samy, Al Hussein Zahran, A. Ali, Medhat Ali
{"title":"Critical appraisal of the emergency management of cardiac conditions during pregnancy in an Egyptian tertiary unit: Newness in paradigms","authors":"M. Mahmoud, Abd Elhalim, M. Ellaban, M. Saleh, Hamdi Mohamed Ali, Khaled M Abdalla, M. Eldeib, Ahmed Ali Faheem, A. Almarghany, M. Samy, Al Hussein Zahran, A. Ali, Medhat Ali","doi":"10.1097/rd9.0000000000000077","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000077","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42049115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.1097/rd9.0000000000000078
S. Fernando, Yang Yan, Manish Kumar, Hoi-Lam Lai, Yin-Lau Lee, E. Ng, W. Yeung, Kai-Fai Lee
{"title":"Multiomics approaches to uncover endometrial receptivity in embryo implantation: A mini-review","authors":"S. Fernando, Yang Yan, Manish Kumar, Hoi-Lam Lai, Yin-Lau Lee, E. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000078","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000078","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43728651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-19DOI: 10.1097/rd9.0000000000000074
S. Kodithuwakku, E. Y. Ng, W. Yeung, Kai-Fai Lee
{"title":"An Update on Hormonal Regulation of Early Embryo-Fallopian Tube Interactions: Insights for Improvements of Assisted Reproduction Technology Outcomes","authors":"S. Kodithuwakku, E. Y. Ng, W. Yeung, Kai-Fai Lee","doi":"10.1097/rd9.0000000000000074","DOIUrl":"https://doi.org/10.1097/rd9.0000000000000074","url":null,"abstract":"","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43283689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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