Children (12–18 Years Age) of Women with Epilepsy Have Lower Intelligence, Attention, and Memory: Observations from the Kerala Registry of Epilepsy and Pregnancy

Abstract

Objective: To present an epilepsy surgery case report from the Comprehensive Epilepsy Program (CEP) at Austin Health (Heidelberg, Victoria, Australia). In this case, multimodal imaging-guided stereo EEG allowed for a “super-focal” resection adjacent to eloquent cortex with excellent postsur-gical outcome. Methods: Patient records at the Austin Health were reviewed. Clinical details and investigations were summa-rized. The patient underwent video EEG monitoring, MRI at 3 and 7 Tesla, MEG, PET, SPECT (ictal and interictal), function-al-MRI (EEG-fMRI and resting state functional connectivity) prior to proceeding to invasive monitoring using stereo-EEG and electrical stimulation. Results: All investigations were reviewed at the Comprehensive Epilepsy Program Meeting at Austin health and a plan was formulated for a very limited parietal corticectomy adjacent to eloquent cortex. The patient underwent surgery without suffering a neurological deficit, and had an excellent outcome (Engel class 1B) at 12 months. Conclusion: In selected cases, excellent outcomes can be achieved using multimodal imaging guided stereotactically complaints and address the mood issues to reduce burden of memory dysfunction in patients with epilepsy. Objective: We aimed to study the cognitive outcome of 12- to 18-year old children of women with epilepsy (WWE). Methods: Children under fol-low-up in Kerala Registry of and evaluated with Wisconsin Card Sorting Test (WCST), trail test Rey auditory verbal learning test Rey–Osterrieth Objectives: Depression is a major comorbidity in persons with epilepsy ( p WE). The effect of antidepressants sertraline (SRT) and escitalopram (ESC) in combination with sodium valproate (SV) and levetiracetam (LEV) on seizure and cognitive impairment in rats was studied. questionnaire. A video electroenceph-alography and CT brain (MRI in focal seizures) in all patients.