Treatment with Gaoziban Tablet Ameliorates Depression by Promoting GSK-3β Phosphorylation to Enhance the Wnt/β-catenin Activation in the Hippocampus of Rats

Xin Zou, Hailong Yin, Lei Shi, Hai-ping Li, Mengheng Wang, Wanci Song, Yang Luo, Wei-Liang Chen, Hezhen Wu, Yan-fang Yang, Junfeng Zan, Yan-wen Liu, Hanxiong Dan, Q. Yin, Pengtao You
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Abstract

Depression is a severe and recurrent mental disease and contributes to the global disease burden. However, there are limited effective treatments for depression. This study evaluated the effect of a compound Gaoziban tablet (CGZBT) on depression and explored its potential mechanisms that underlie its action in rats.

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高子板片通过促进GSK-3β磷酸化增强大鼠海马Wnt/β-catenin激活改善抑郁症
抑郁症是一种严重且反复发作的精神疾病,加重了全球疾病负担。然而,抑郁症的有效治疗方法有限。本研究评价了复方高子班片(CGZBT)对大鼠抑郁症的影响,并探讨了其作用机制。
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