Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC Heterocyclic Communications Pub Date : 2020-01-01 DOI:10.1515/hc-2020-0008

Ali Irfan, Laila Rubab, Mishbah Ur Rehman, R. Anjum, S. Ullah, Mahwish Marjana, Saba Qadeer, Sadia Sana

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引用次数: 18

Abstract

Abstract Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.

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香豆素磺酰胺衍生物：一类新兴的治疗剂

摘要香豆素磺酰胺是一个杂环药效团，也是一个重要的结构基序，是不同治疗支架和类似物的核心和组成部分。香豆素磺酰胺是一种特殊的关键模板，在医学、药理学和药学领域有着广泛的应用。香豆素磺酰胺具有抗菌、抗病毒、抗真菌、抗炎和抗癌等多种生物医学活性。本文从结构-活性关系（SAR）的角度综述香豆素磺酰胺衍生物在治疗不同致死性疾病中的结构特征。这篇综述文章中引用的大量研究总结并讨论了香豆素磺酰胺核周围的各种取代，这些取代提供了广泛的生物活性和治疗潜力，这对许多希望利用香豆素磺酰胺骨架进行药物发现和开发新型治疗剂的研究人员具有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.