Function and treatment strategies of β-hydroxybutyrate in aging

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2022.09.003
Yang Xiang , Qi-Quan Wang , Xin-Qiang Lan , Hui-Jie Zhang , Dai-Xu Wei
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引用次数: 3

Abstract

Metabolic intermediates serve as precursors for bioactive molecule synthesis, the energy source for life activities, and signals for environmental adaptation. Ketone bodies are important metabolic intermediates produced in the liver by the degradation of fatty acids, acting as an alternative energy source for extrahepatic tissues when glucose is short in supply (especially during starvation). β-hydroxybutyric acid, with its conjugate base β-hydroxybutyrate, constitutes approximately 70% of ketone bodies. A growing number of studies have demonstrated the beneficial effects of β-hydroxybutyrate, especially in delaying aging, intervening in aging-related disease, and promoting longevity. This review systematically reviews the role of β-hydroxybutyrate in aging hallmarks, shedding light on the possible molecular mechanism by which β-hydroxybutyrate supports healthy aging. Higher circulating β-hydroxybutyrate can be achieved by lifestyle modification (ketogenic diet or caloric restriction) or exogenous β-hydroxybutyrate (or β-hydroxybutyrate precursors, derivates and agonists) supplementation. We will also discuss the pros and cons of different ways to upregulate β-hydroxybutyrate, emphasizing the promising future clinical use of poly-β-hydroxybutyrate, the polymers of β-hydroxybutyrate, which can be easily produced via a microbial platform and synthetic biology.

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β-羟基丁酸酯在衰老中的作用及治疗策略
代谢中间体是生物活性分子合成的前体,是生命活动的能量来源,是适应环境的信号。酮体是肝脏通过脂肪酸降解产生的重要代谢中间体,在葡萄糖供应不足时(特别是饥饿时)作为肝外组织的替代能量来源。β-羟基丁酸及其共轭碱β-羟基丁酸盐约占酮体的70%。越来越多的研究证明了β-羟基丁酸酯的有益作用,特别是在延缓衰老、干预衰老相关疾病和促进长寿方面。本文系统综述了β-羟基丁酸盐在衰老标志中的作用,揭示了β-羟基丁酸盐支持健康衰老的可能分子机制。可以通过改变生活方式(生酮饮食或热量限制)或补充外源性β-羟基丁酸盐(或β-羟基丁酸前体、衍生物和激动剂)来提高β-羟基丁酸盐的循环水平。我们还将讨论上调β-羟基丁酸盐的不同方法的利弊,强调β-羟基丁酸盐的聚合物聚β-羟基丁酸盐的临床应用前景广阔,它可以很容易地通过微生物平台和合成生物学来生产。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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