{"title":"The emerging role of mitochondrial dysfunction in the pathogenesis and treatment of diabetic complications","authors":"H. Qu, Yi Zheng, Xiaoli Gong, Hongting Zheng","doi":"10.3760/CMA.J.ISSN.1000-6699.2020.02.014","DOIUrl":null,"url":null,"abstract":"Mitochondrial dysfunction plays an important role in the pathogenesis of diabetic complications, and more attention has been paid to the treatment strategies targeting mitochondrial function in these diseases. Our group has been devoted to exploring the relationship between mitochondrial dysfunction such as mitochondrial oxidative stress and energy metabolism, as well as various diabetic complications. This review highlighted recent progresses in the role of mitochondrial dysfunction in the pathogenesis of diabetic ulcer, diabetic nephropathy, diabetes complicated with nonalcoholic fatty liver and their correspondent molecular pathways, tried to explore the feasibility of targeting mitochondrial dysfunction in the treatment of these diseases. \n \nKey words: \nMitochondria; Dysfunction; Diabetes mellitus; Complications","PeriodicalId":10120,"journal":{"name":"中华内分泌代谢杂志","volume":"36 1","pages":"161-164"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华内分泌代谢杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2020.02.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Mitochondrial dysfunction plays an important role in the pathogenesis of diabetic complications, and more attention has been paid to the treatment strategies targeting mitochondrial function in these diseases. Our group has been devoted to exploring the relationship between mitochondrial dysfunction such as mitochondrial oxidative stress and energy metabolism, as well as various diabetic complications. This review highlighted recent progresses in the role of mitochondrial dysfunction in the pathogenesis of diabetic ulcer, diabetic nephropathy, diabetes complicated with nonalcoholic fatty liver and their correspondent molecular pathways, tried to explore the feasibility of targeting mitochondrial dysfunction in the treatment of these diseases.
Key words:
Mitochondria; Dysfunction; Diabetes mellitus; Complications
中华内分泌代谢杂志Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
0.60
自引率
0.00%
发文量
7243
期刊介绍：
The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.
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