Comparison of ultrasound findings and fine needle aspiration results between anti-thyroid peroxidase positive and negative patients with nodular goiters

IF 1.1 Q4 IMMUNOLOGY Immunopathologia Persa Pub Date : 2022-04-17 DOI:10.34172/ipp.2022.24257
M. Malekian, Nasser Aghamohammadzadeh, F. Najafipour, Reza Javad-Rashid, J. Jalili, M. Halimi, F. Bozorgi, Jalil Houshyar
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Abstract

Introduction: Ultrasonography is an optimal approach for thyroid gland evaluation, nodule detection and cancer risk assessment in patients with thyroid nodules. Almost all patients with Hashimoto’s thyroiditis have high levels anti-thyroid peroxidase (anti-TPO) antibodies. Objectives: This study aimed to evaluate the relationship between ultrasonography and fine needle aspiration (FNA) results in anti-TPO antibodies positive and negative patients with nodular goiters. Patients and Methods: This cross-sectional study included 128 patients with nodular goiters, referred to endocrinology clinic of imam Reza hospital, Tabriz, Iran. Anti-TPO levels above and below 16 IU/mL were considered as positive and negative, respectively. All patients underwent thyroid ultrasonography, and eligible nodules were subjected to FNA. Results: Of 128 patients, 33.6% and 66.4% were anti-TPO positive and negative, respectively. FNA was conducted on 196 nodules. A significant relationship was observed between sonographic and FNA results in low and intermediate-suspicion nodules. Chronic lymphocytic thyroiditis (CLT) was more frequently reported in low-suspicion nodules of the anti-TPO positive group (P≤0.0001). In addition, in intermediate-suspicion nodules, CLT was reported in 33.3% of patients in the anti-TPO positive group (P=0.026). No significant difference was observed between other nodules. Conclusion: Based on our findings, when a nodule is classified in low or intermediate-suspicion categories, the possibility of CLT following FNA is significantly higher in the anti-TPO positive group, compared to the anti-TPO negative group.
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抗甲状腺过氧化物酶阳性与阴性结节性甲状腺肿的超声表现及细针穿刺结果比较
简介:超声检查是甲状腺结节患者甲状腺评估、结节检测和癌症风险评估的最佳方法。几乎所有桥本甲状腺炎患者都有高水平的抗甲状腺过氧化物酶(抗TPO)抗体。目的:本研究旨在评估结节性甲状腺肿抗TPO抗体阳性和阴性患者的超声检查与细针抽吸(FNA)结果之间的关系。患者和方法:这项横断面研究包括128名结节性甲状腺肿患者,他们被转诊到伊朗大不里士伊玛目礼萨医院内分泌诊所。抗TPO水平高于和低于16IU/mL分别被认为是阳性和阴性。所有患者均接受了甲状腺超声检查,符合条件的结节均接受了FNA检查。结果:128例患者中,抗TPO阳性率为33.6%,阴性率为66.4%。对196个结节进行了FNA检查。在低度和中度可疑结节中,超声检查和FNA结果之间存在显著关系。慢性淋巴细胞性甲状腺炎(CLT)在抗TPO阳性组的低怀疑结节中更常见(P≤0.0001)。此外,在中等怀疑结节中,抗TPO阴性组33.3%的患者报告了CLT(P=0.026)。其他结节之间没有观察到显著差异。结论:根据我们的研究结果,当结节被分为低或中等怀疑类别时,与抗TPO阴性组相比,抗TPO阳性组在FNA后发生CLT的可能性显著更高。
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CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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