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The enhancement of therapeutic effects of low-intensity ultrasound with spiky and spherical gold nanoparticles on CT26 cell line; an in vitro study 用尖状和球状金纳米粒子增强低强度超声对 CT26 细胞株的治疗效果;一项体外研究
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2024-01-29 DOI: 10.34172/ipp.2024.40596
Molood Gooniband Shooshtari, M. Shiran, Sakine Shirvalilou
Introduction: The utilization of combination therapy has gained attention in the medical field as it can enhance treatment efficacy while minimizing side effects. Gold nanoparticles (AuNPs) have been identified as a promising candidate for enhancing the bioeffects of ultrasound (US) waves. Objectives: The primary objective of this study was to examine the impact of US irradiation when combined with spiky and spherical AuNPs on CT26 cells. Materials and Methods: Following a tailored composition, we devised and produced AuNPs with spiky and spherical morphologies. The properties of these nanoparticles were assessed using dynamic light scattering (DLS), voltammetry, and transmission electron microscopy (TEM). The CT26 cells were treated with the two types of nanoparticles and subsequently exposed to US radiation (1 W/cm2 , 1 MHz, and 10 minutes). The cytotoxic effects of various therapeutic interventions were assessed using MTT and flow cytometry assays. Results: This study’s findings indicate that nanoparticles’ morphology played a significant role in influencing the antitumor effects of US. Specifically, it was observed that the presence of spiky nanoparticles, when subjected to US, resulted in a significantly higher rate of cell death compared to spherical nanoparticles (P<0.001). Additionally, it was observed that the temperature changes induced by the spiky nanoparticles were comparatively lower. This observation implies that nanoparticles with spiky morphology enhance the non-thermal effects of US waves. Conclusion: The outcomes demonstrate a noteworthy augmentation in the biological impacts, specifically the non-thermal effects of US waves when employed in conjunction with spiky nanoparticles.
简介联合疗法可以提高治疗效果,同时最大限度地减少副作用,因此在医学领域备受关注。金纳米粒子(AuNPs)被认为是增强超声波(US)生物效应的理想候选物质。研究目的本研究的主要目的是考察 US 照射与尖状和球状 AuNPs 结合使用时对 CT26 细胞的影响。材料与方法:根据定制的成分,我们设计并生产了具有尖状和球状形态的 AuNPs。我们使用动态光散射(DLS)、伏安法和透射电子显微镜(TEM)评估了这些纳米粒子的特性。用这两种纳米粒子处理 CT26 细胞,然后将其暴露于 US 辐射(1 W/cm2、1 MHz、10 分钟)。使用 MTT 和流式细胞术测定评估了各种治疗干预措施的细胞毒性效果。结果:研究结果表明,纳米颗粒的形态对 US 的抗肿瘤效果有重要影响。具体来说,观察发现,与球形纳米粒子相比,在使用 US 时,尖头纳米粒子的细胞死亡率明显更高(P<0.001)。此外,还观察到尖状纳米粒子引起的温度变化相对较低。这一观察结果表明,具有尖刺形态的纳米粒子能增强 US 波的非热效应。结论研究结果表明,与尖状纳米粒子一起使用时,US 波对生物的影响,特别是非热效应,会显著增强。
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引用次数: 0
Diagnostic importance of P16 in the differential diagnosis of well-differentiated liposarcoma and lipomas P16 在鉴别诊断分化良好的脂肪肉瘤和脂肪瘤中的诊断重要性
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2024-01-29 DOI: 10.34172/ipp.2023.40558
P. Hedayat, M. Derakhshan, Laya Golshani, Arash Hedayat
Introduction: Because of pathological overlaps, distinguishing well-differentiated liposarcoma (WDL) from lipoma is difficult. Objectives: The purpose of this study was to evaluate P16 as a differentiating marker for WDL and lipomas Materials and Methods: This cross-sectional study was performed on 38 pathology samples of lipoma and WDL in the department of pathology of Al-Zahra hospital, affiliated with Isfahan university of medical sciences, from 2011 to 2018. The studied samples were examined by immunohistochemistry (IHC) to determine the presence of P16. Results: Evaluation of IHC data showed that all of the lipoma samples (100%) had a score of 0 for IHC staining. In comparison, 84.2% of liposarcoma samples had a score of 3, and this difference was statistically significant (P<0.001). Evaluating the sensitivity and specificity of P16 gene expression showed that this marker has 84% sensitivity and 100% specificity for diagnosing liposarcoma (95% CI: 0.6042-0.9661). Conclusion: The use of p16 to differentiate WDL from lipoma has a sensitivity of 84% and a specificity of 100%, which could be very helpful in pathological practice.
导言:由于病理重叠,很难将分化良好的脂肪肉瘤(WDL)与脂肪瘤区分开来。研究目的本研究旨在评估 P16 作为区分 WDL 和脂肪瘤的标志物的作用:本横断面研究于 2011 年至 2018 年期间在伊斯法罕医科大学附属扎赫拉医院病理科对 38 份脂肪瘤和 WDL 的病理样本进行了研究。研究样本通过免疫组化(IHC)检测P16的存在。结果显示IHC 数据评估显示,所有脂肪瘤样本(100%)的 IHC 染色得分均为 0。相比之下,84.2%的脂肪肉瘤样本的 IHC 得分为 3,这一差异具有统计学意义(P<0.001)。对 P16 基因表达的敏感性和特异性进行评估后发现,该标记物对脂肪肉瘤诊断的敏感性为 84%,特异性为 100%(95% CI:0.6042-0.9661)。结论使用P16来区分WDL和脂肪瘤的敏感性为84%,特异性为100%,这对病理实践很有帮助。
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引用次数: 0
A rare case of hydatid cyst in the chordae tendineae of papillary muscle of the right ventricle 右心室乳头肌腱索水瘤囊肿的罕见病例
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2024-01-29 DOI: 10.34172/ipp.2023.40598
M. Hekmat, H. Ghaderi, Zahra Ansari Aval, S. Mirjafari, R. Tirdad
Hydatid cyst inside the cardiac chambers, especially the right ventricle, is a rare manifestation of the Echinococcus granulosus infection. We present a rare case of a mobile hydatid cyst on the chordae tendineae of the right ventricular papillary muscle. An 11-year-old male patient presented with multiple cysts in the body (numerous ones in the lung and liver) who had undergone left lung lobectomy due to a hydatid cyst prone to rupture. In the subsequent echocardiography, a fully mobile cyst measuring 2×1.5 cm was noticed in the right ventricle. Although the child had no cardiac presentation, due to the risk posed by its location and the high probability of sudden death or embolism, he underwent a successful cardiac and pulmonary bypass operation, and the cyst was completely excised. It was located on the chordae tendineae of the papillary muscle. In agricultural and rural countries and regions, cardiac hydatid cysts should be considered at any age. Due to the high risk of complications and mortality in cardiac hydatid cysts, regardless of the symptoms, inpatients with a positive history, cardiac examination with echocardiography must be included in diagnostic protocols. These cysts should be surgically removed as soon as possible on diagnosis, regardless of the symptoms.
心腔(尤其是右心室)内的包虫囊肿是棘球蚴感染的一种罕见表现。我们报告了一例罕见的右心室乳头肌腱索上移动性包虫囊肿病例。一名 11 岁的男性患者因易破裂的包虫囊肿接受了左肺叶切除术,患者体内有多个囊肿(肺部和肝脏有多个囊肿)。在随后的超声心动图检查中,发现右心室有一个 2×1.5 厘米的完全活动囊肿。虽然患儿没有心脏方面的表现,但由于囊肿位置危险,极有可能发生猝死或栓塞,因此他成功接受了心肺搭桥手术,囊肿被完全切除。囊肿位于乳头肌腱索上。在农业和农村国家和地区,任何年龄都应考虑心脏水瘤囊肿。由于心脏包虫囊肿的并发症和死亡率风险很高,因此无论症状如何,有阳性病史的住院病人都必须将超声心动图心脏检查纳入诊断方案。这些囊肿一经确诊,无论症状如何,都应尽快手术切除。
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引用次数: 0
Sacral extradural spinal meningioma with recurrence; a case report 骶骨硬膜外脊髓脑膜瘤复发;病例报告
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2024-01-13 DOI: 10.34172/ipp.2023.40603
M. Farrokhi, Abbas Khosravifarsani, Mavlonov Jaloliddin Begijonovich
Extradural spinal meningiomas are very uncommon, and just a scattering of clinical reports on this condition have been published. Despite being benign, epidural meningiomas exhibit a higher recurrence rate compared to typical meningiomas. In this case report, we described a case of sacral extradural spinal meningioma with several episodes of recurrence and discussed the clinical characteristics, radiological features, and management, along with follow-up details. A 19-year-old woman with back discomfort and lower extremity numbness. Magnetic resonance imaging (MRI) revealed a tumor on the left posterolateral S1–S2 spinal cord. L5–S3 hemilaminectomy and foraminotomy were performed. After three years, the patient had bilateral L4–S1 laminectomy and radiotherapy for tumor recurrence. Two years later, the patient presented with pain and paresthesia in the lower limbs and was diagnosed with a tumor recurrence once more. Due to sacral area adhesion from earlier surgeries and radiation, the patient received CyberKnife radiation instead of tumor resection. No complaints or signs of recurrence were detected during follow-up examinations. Extradural spinal meningiomas are uncommon and can occasionally be misidentified as malignant metastatic tumors both before and during surgery. This misclassification could potentially lead to alterations in the recommended surgical approach. Although epidural spinal meningiomas are often benign, their long-term prognosis is uncertain, and the recurrence rate is higher than ordinary meningiomas. Hence, lengthy monitoring is necessary to identify any recurrence risk (like our case).
脊髓硬膜外脑膜瘤非常罕见,关于这种疾病的临床报告也寥寥无几。硬膜外脑膜瘤虽然是良性肿瘤,但与典型脑膜瘤相比,复发率较高。在本病例报告中,我们描述了一例多次复发的骶骨硬膜外脊膜瘤,并讨论了其临床特点、放射学特征、处理方法以及随访细节。患者为一名 19 岁女性,背部不适,下肢麻木。磁共振成像(MRI)显示左侧 S1-S2 脊髓后外侧有一肿瘤。患者接受了 L5-S3 半椎板切除术和椎板切除术。三年后,患者因肿瘤复发接受了双侧 L4-S1 椎板切除术和放疗。两年后,患者出现下肢疼痛和麻痹,再次被诊断为肿瘤复发。由于之前的手术和放疗导致骶骨部位粘连,患者接受了 CyberKnife 放射治疗,而不是肿瘤切除术。随访检查中未发现复发的主诉或迹象。脊髓外膜脑膜瘤并不常见,在手术前和手术中偶尔会被误诊为恶性转移瘤。这种错误分类有可能导致推荐的手术方法发生改变。虽然脊髓硬膜外脑膜瘤通常是良性的,但其长期预后并不确定,复发率也高于普通脑膜瘤。因此,有必要进行长期监测,以发现复发风险(如我们的病例)。
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引用次数: 0
Evaluation and comparison of the results of the Alvarado scoring system with acute inflammatory response score in the diagnosis of acute appendicitis based on the pathological evidence 根据病理证据评估和比较阿尔瓦拉多评分系统与急性炎症反应评分在诊断急性阑尾炎中的结果
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2024-01-13 DOI: 10.34172/ipp.2024.40606
M. Safaee, Reza Eshraghi Samani, Hamid Talebzadeh, Mohammad Soheil Moeini Sam
Introduction: Although appendectomy is the most common reason for abdominal surgery, acute appendicitis (AA) diagnosis remained a challenging issue using various scoring systems. Objectives: The current study aims to investigate the diagnostic value of the Alvarado scoring system versus the acute inflammatory response score (AIRS) in the diagnosis of AA. Patients and Methods: The current cross-sectional study was conducted on 120 patients who underwent appendectomy between 2019 and 2020. The on-admission Alvarado and AIRS scores were evaluated for the patients. Besides, the histopathological study of the resected tissues was considered the gold standard. The receiver operating characteristics (ROC) curve was depicted for the scoring systems, and sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV), and area under the curve (AUC) were calculated. Results: The sensitivity, specificity, NPV, and PPV of Alvarado criteria for scores >4 equaled 89.3%, 23.5%, 35.2%, and 89.3%, respectively. These amounts were calculated as 96.1%, 82.3%, 77.7%, and 97% for the AIRS, respectively. Moreover, at cut-points >8, the sensitivity of 32.1%, specificity of 100%, PPV of 100%, and NPV of 15.7% have been measured for AIRS compared with 41.7%, 88.2%, 97.1%, and 29.4% for Alvarado, respectively. The measured AUC for AIRS and Alvarado criteria accounted for 0.81 and 0.72, respectively (P value <0.05). Besides, 17 (14.16%) ones had a negative appendectomy. Conclusion: Based on the current study’s findings, both AIRS and Alvarado scoring systems were reliable means to diagnose appendicitis; however, AIRS was relatively superior considering its higher specificity and PPV in scores >8 and higher sensitivity and NPV in scores >4.
简介:虽然阑尾切除术是腹部手术最常见的原因,但使用各种评分系统来诊断急性阑尾炎(AA)仍是一个具有挑战性的问题。研究目的本研究旨在探讨阿尔瓦拉多评分系统与急性炎症反应评分(AIRS)在 AA 诊断中的诊断价值。患者和方法:本横断面研究针对 2019 年至 2020 年间接受阑尾切除术的 120 名患者。对患者入院时的 Alvarado 和 AIRS 评分进行了评估。此外,切除组织的组织病理学研究被视为金标准。描述了评分系统的接收器操作特征曲线(ROC),并计算了灵敏度、特异性、阴性预测值(NPV)和阳性预测值(PPV)以及曲线下面积(AUC)。结果阿尔瓦拉多标准对评分大于 4 分的敏感性、特异性、NPV 和 PPV 分别为 89.3%、23.5%、35.2% 和 89.3%。而 AIRS 的计算结果分别为 96.1%、82.3%、77.7% 和 97%。此外,在切点大于 8 时,AIRS 的灵敏度为 32.1%,特异性为 100%,PPV 为 100%,NPV 为 15.7%,而 Alvarado 的灵敏度、特异性、PPV 和 NPV 分别为 41.7%、88.2%、97.1% 和 29.4%。测得的 AIRS 和 Alvarado 标准的 AUC 分别为 0.81 和 0.72(P 值为 8),得分大于 4 分的灵敏度和 NPV 较高。
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引用次数: 0
Investigation of the level of agreement between bone mineral density and trabecular bone score regarding gender, age and body mass index 调查骨矿物质密度和骨小梁评分在性别、年龄和体重指数方面的一致程度
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2023-12-05 DOI: 10.34172/ipp.2022.29296
Alireza Rajaei, Ideh Kamkar, F. Farsad
Introduction: Increasing and maintaining bone density can play a role in preventing osteoporosis, as changes in the trabecular bone score (TBS) and bone mineral density (BMD) affect bone density, especially in the spine. Objectives: The present study aimed to determine the level of agreement between TBS and BMD in patients with osteoporosis and also to investigate the relationship between these two indices with body mass index (BMI). Patients and Methods: Data were collected from 843 patients, referred to the densitometry department of Resalat hospital. BMD and TBS were measured in the subjects to determine the risk of osteoporosis. The results of BMD were measured based on T-score level. The patients’ individual and clinical characteristics were also recorded and factors influencing the prognosis of density changes were evaluated. Moreover, the effect of BMI was investigated in this study. Results: The mean age of patients was 55.5 years. The kappa coefficient and Spearman’s correlation coefficient of BMD and TBS were 0.004 and -0.015, respectively. There was a significant correlation between BMI and BMD in men. The kappa coefficient gradually increased from normal bone density to osteoporosis. There was a significant negative correlation between BMI and BMD, while a significant positive correlation between height and BMD in women was existed. On the other hand, a significant negative correlation between weight and BMD was detected accordingly. Conclusion: According to the results of our study, there is no agreement between BMD and TBS.
导论:增加和维持骨密度可以预防骨质疏松症,因为骨小梁评分(TBS)和骨矿物质密度(BMD)的变化会影响骨密度,尤其是脊柱。目的:本研究旨在确定骨质疏松症患者TBS和BMD之间的一致程度,并探讨这两个指标与体重指数(BMI)之间的关系。患者和方法:资料收集自Resalat医院密度测量科转诊的843例患者。测量受试者的骨密度和TBS以确定骨质疏松症的风险。以T-score水平测定骨密度。记录患者的个体及临床特征,评价影响密度变化预后的因素。此外,本研究还探讨了BMI的影响。结果:患者平均年龄55.5岁。骨密度与TBS的kappa系数和Spearman相关系数分别为0.004和-0.015。在男性中,BMI和BMD之间存在显著的相关性。从骨密度正常到骨质疏松,kappa系数逐渐增大。BMI与骨密度呈显著负相关,女性身高与骨密度呈显著正相关。另一方面,体重与骨密度呈显著负相关。结论:根据我们的研究结果,骨密度与TBS之间没有一致性。
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引用次数: 0
The effectiveness of gabapentin in treating overactive bladder: a quasi-experimental study 加巴喷丁治疗膀胱过度活动症的效果:一项准实验研究
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2023-12-04 DOI: 10.34172/ipp.2023.40574
Malik Ayyad, Omar Ayaad, Hassan Alkhatatbeh, F. Sawaqed, Samer Al-Rawashdeh, Bayan Qaddumi
Introduction: Overactive bladder (OAB) is a common condition in urology that affects individuals of various ages and genders, significantly impacting their quality of life. Objectives: The study aimed to examine the effectiveness of gabapentin in treating OAB in Jordan. Patients and Methods: This study was conducted at a private clinic in Jordan between 2020 and 2022. It utilized a one-group pre- and post-test design involving 50 patients. The intervention involved administering gabapentin at a daily dose of 400 mg. The effectiveness of gabapentin was evaluated using the overactive bladder symptom score (OABSS) questionnaire, administered before and after six weeks of gabapentin administration. Results: The study sample consisted of 50 patients aged between 45 and 85 years, with a mean age of 65.2 years. After the treatment, all individual variables, such as urgency, frequency, nocturia, and urgency incontinence, showed significant reductions compared to the pre-intervention values. The mean total OABSS significantly decreased from 14.6 before to 6.8 after the intervention. The paired t test yielded a result of 9.84 with a P value of less than 0.001, indicating a statistically significant improvement. Conclusion: The noteworthy improvement in OABSS scores, urgency, nocturia, frequency of micturition, and urge incontinence observed in this study suggests that gabapentin could have a role as a treatment option for OAB patients.
膀胱过动症(OAB)是泌尿科的一种常见疾病,可影响不同年龄和性别的个体,严重影响其生活质量。目的:研究加巴喷丁治疗约旦OAB的有效性。患者和方法:本研究于2020年至2022年在约旦的一家私人诊所进行。它采用了一组测试前和测试后的设计,涉及50名患者。干预包括给予加巴喷丁每日400mg的剂量。加巴喷丁的有效性通过膀胱过度活动症状评分(OABSS)问卷进行评估,在加巴喷丁给药前和给药后6周。结果:研究样本包括50例患者,年龄在45 ~ 85岁之间,平均年龄65.2岁。治疗后,所有个体变量,如尿急、尿频、夜尿和尿急失禁,均较干预前显著降低。平均总OABSS由干预前的14.6显著下降至干预后的6.8。配对t检验结果为9.84,P值小于0.001,有统计学意义的改善。结论:本研究中观察到的OABSS评分、尿急、夜尿、排尿频率和急迫性尿失禁的显著改善表明加巴喷丁可以作为OAB患者的治疗选择。
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引用次数: 0
Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients 伊拉克慢性乙型肝炎病毒患者中病毒载量和自噬相关基因多态性与乙型肝炎病毒前核/核心突变的关系
Q3 Immunology and Microbiology Pub Date : 2023-09-23 DOI: 10.34172/ipp.2023.40575
Abdulhussain Kadhim Jwaziri, Maryam Esghaei, Mohammad Hadi Karbalaie Niya, Mohsen Mehrjoo, Hadi Abd Zaid Sayah, Hossein Keyvani
Introduction: Chronic hepatitis B (CHB) is a global concern due to its association with cirrhosis and hepatocellular carcinoma (HCC) development. The interplay between viral load, the immune system, and host factors is critical in tumorigenesis. Autophagy is a significant contributor to immune system function, since vitamin D plays an important role in this context. Objectives: The objective of this study was to assess the association between ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, viral load, and vitamin D with HBV pre-C/C mutations in Iraqi patients with CHB. Patients and Methods: In this cross-sectional study, a total of 134 CHB patients were evaluated for ATG polymorphisms, viral load, and vitamin D levels. Blood samples were collected after obtaining ethical consent, and the mutations were analyzed using polymerase chain reaction (PCR) followed by Sanger sequencing. Serum samples from CHB patients were used for viral load and vitamin D assessment. Results: The evaluation of patients revealed that 67 (44.6%) were male and 83 (55.4%) were female, with a mean age of 36±12.7 years and a mean duration of infection of 5.2±4.8 years. Mutations in pre-C/C were observed in 20% (27/134) of the patients. There was a significant association between all evaluated ATG polymorphisms and pre-C/C mutants (P<0.05). Furthermore, there was an association between viral load and mutations in pre-C/C (P=0.03), while no statistically significant difference was found between vitamin D levels and pre-core/core mutants or viral load. Conclusion: Our study demonstrates a higher frequency of ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, as well as a higher viral load in Iraqi CHB patients with HBV pre-C/C mutations.
慢性乙型肝炎(CHB)是一个全球关注的问题,因为它与肝硬化和肝细胞癌(HCC)的发展有关。病毒载量、免疫系统和宿主因子之间的相互作用是肿瘤发生的关键。自噬是免疫系统功能的重要贡献者,因为维生素D在此背景下起着重要作用。目的:本研究的目的是评估ATG5 (rs506027和rss510432)和ATG16L1 (rs2241880和ATG16 rs2241879)多态性、病毒载量和维生素D与伊拉克CHB患者HBV前C/C突变之间的关系。患者和方法:在这项横断面研究中,对134名慢性乙型肝炎患者进行了ATG多态性、病毒载量和维生素D水平的评估。获得伦理同意后采集血样,采用聚合酶链反应(PCR)分析突变,然后进行Sanger测序。采用慢性乙型肝炎患者血清样本进行病毒载量和维生素D评估。结果:男性67例(44.6%),女性83例(55.4%),平均年龄36±12.7岁,平均感染时间5.2±4.8年。在20%(27/134)的患者中观察到pre-C/C突变。所有评估的ATG多态性与预C/C突变体之间存在显著相关性(P<0.05)。此外,病毒载量与pre-C/C突变之间存在相关性(P=0.03),而维生素D水平与pre-core/core突变或病毒载量之间无统计学差异。结论:我们的研究表明,ATG5 (rs506027和rss510432)和ATG16L1 (rs2241880和ATG16 rs2241879)多态性的频率更高,并且在伊拉克CHB患者中HBV pre-C/C突变更高的病毒载量。
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引用次数: 0
Impact of analgesics on the risk of ovarian cancer; a systematic review and meta-analysis of cohort and case-control studies 镇痛药对卵巢癌发病风险的影响队列研究和病例对照研究的系统回顾和荟萃分析
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2023-08-22 DOI: 10.34172/ipp.2023.40572
Javad Sadeghi, Saba Bazzazi, Farinaz Fattahi, Moloud Alsadat Mousavi, Ardeshir Tajbakhsh, Sadaf Rassouli, Siavash Sangi, Mahshad Ghezelbash, Anna Ghorbani
Introduction: Ovarian cancer is the sixth leading cancer-related mortality cause in women worldwide. Analgesics may hinder the occurrence of ovarian cancer through inflammation relief. The present study seeks to examine the relationship between analgesic consumption and ovarian cancer risk through a systematic review and meta-analysis. Materials and Methods: PubMed, Scopus, Web of Science, Cochrane databases, and Google Scholar search engines were searched for works published by May 2023 using standard keywords to collect the required data sources. Acquired data were then analyzed in STATA version14, considering a significance level of P < 0.05 in statistical tests. Results: The present meta-analysis comprised 21 studies (14 case-control and 7 cohort studies) performed on 53,755 subjects. Results indicated that taking aspirin reduced the risk of ovarian cancer by 8% (OR: 0.92; 95% CI: 0.87, 0.98), whereas other non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) did not significantly affect the ovarian cancer risk (OR: 0.91; 95% CI: 0.81, 1.02). Similar results were observed in the case of ibuprofen and acetaminophen, with non-significant relationships between the risk of ovarian cancer and with the consumption of both acetaminophen (OR: 0.95; 95% CI: 0.84, 1.08) and ibuprofen (OR: 0.76; 95% CI: 0.50, 1.14). Furthermore, the duration of analgesic consumption was not significantly linked to the risk of ovarian cancer in the case of all studied drugs. Conclusion: Among aspirin, ibuprofen, acetaminophen, and non-aspirin NSAIDs, only aspirin was found to reduce the risk of ovarian cancer in women while the other studied drugs did not influence the studied risk. However, further research is recommended to confirm the results. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023434730) and Research Registry (UIN: reviewregistry1668) websites.
简介:癌症是全球第六大女性癌症相关死亡原因。镇痛药可能通过炎症缓解来阻碍卵巢癌症的发生。本研究旨在通过系统回顾和荟萃分析来检验镇痛药消耗与卵巢癌症风险之间的关系。材料和方法:PubMed、Scopus、Web of Science、Cochrane数据库和Google Scholar搜索引擎使用标准关键词搜索截至2023年5月发表的作品,以收集所需的数据源。然后在STATA版本14中分析所获得的数据,考虑到统计学检验中P<0.05的显著性水平。结果:本荟萃分析包括对53755名受试者进行的21项研究(14项病例对照研究和7项队列研究)。结果表明,服用阿司匹林可降低卵巢癌症风险8%(OR:0.92;95%CI:0.87,0.98),而其他非阿司匹林类非甾体抗炎药对卵巢癌症风险没有显著影响(OR:0.91;95%CI:0.81,1.02),卵巢癌症风险与对乙酰氨基酚(OR:0.95;95%CI:0.84,1.08)和布洛芬(OR:0.76;95%CI:0.50,1.14)的服用之间无显著关系。结论:在阿司匹林、布洛芬、对乙酰氨基酚和非阿司匹林类非甾体抗炎药中,只有阿司匹林能降低女性患卵巢癌症的风险,而其他研究药物对研究风险没有影响。然而,建议进行进一步的研究来证实这一结果。注册:本研究基于PRISMA检查表编制,其方案已在PROSPERO(CRD42023434730)和研究注册处(UIN:reviewregistry1668)网站上注册。
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引用次数: 0
Impact of COVID-19 on renal transplant recipients 新冠肺炎对肾移植受者的影响
IF 0.8 Q3 Immunology and Microbiology Pub Date : 2023-08-22 DOI: 10.34172/ipp.2023.39489
Ganesan Geethanjali, E. Ramprasad, Sekar Manikantan, M. Jayakumar
Introduction: It was essential to explore immunosuppressant management strategies and potential clinical variables associated with COVID-19 related mortality in order to provide insight for clinicians attempting to manage kidney transplant recipients during the ongoing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic. Objectives: The aim of the study was to assess the impact of COVID-19 on post-transplant renal function and outcome of immunosuppressant management on COVID-19. Patients and Methods: This is a cross sectional observational study conducted from March 2020 to January 2022 in a tertiary care hospital in South India. Baseline characteristics, comorbidities, history of graft dysfunction, symptoms and immunosuppressant modification was noted. Outcomes of COVID-19 such as acute kidney injury (AKI), need for dialysis and post COVID-19 complications were noted. The statistics were expressed as percentage for categorical variables and mean ± SD for continuous variables. Results: Out of 400 renal transplant patients on regular follow up, 28 patients developed COVID-19. The incidence of AKI was 64.2%. Immunosuppressant dose modification was done in majority of patients [mycophenolate mofetil (28.5%), steroids (53.5%) and tacrolimus (39.2%)]. Outcomes included recovery from AKI in 61.1%, recovery from oxygen dependence in 100% patients with an overall mortality rate of 7.1% patients. About 17.8% patients developed post-COVID-19 complications. Conclusion: Immunosuppressant dose modification during COVID-19 could play a role in development of AKI; infection being an independent risk factor. Patients should be monitored for development of post-COVID-19 complications.
简介:有必要探索与新冠肺炎相关死亡率相关的免疫抑制剂管理策略和潜在临床变量,以便为临床医生在持续的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行期间尝试管理肾移植受者提供见解。目的:本研究的目的是评估新冠肺炎对移植后肾功能的影响以及免疫抑制剂管理对新冠肺炎的结果。患者和方法:这是一项2020年3月至2022年1月在南印度一家三级护理医院进行的横断面观察性研究。记录基线特征、合并症、移植物功能障碍史、症状和免疫抑制剂修饰。注意到新冠肺炎的结果,如急性肾损伤(AKI)、需要透析和新冠肺炎后并发症。统计数据以分类变量的百分比表示,连续变量的平均值±标准差表示。结果:在400名定期随访的肾移植患者中,28名患者出现新冠肺炎。AKI的发生率为64.2%。大多数患者都进行了免疫抑制剂剂量调整[霉酚酸酯(28.5%)、类固醇(53.5%)和他克莫司(39.2%)]。结果包括61.1%的患者从AKI中恢复,100%的患者从氧依赖中恢复,总死亡率为7.1%。约17.8%的患者出现新冠肺炎后并发症。结论:新冠肺炎期间免疫抑制剂剂量的改变可能在AKI的发展中起作用;感染是一个独立的危险因素。应对患者进行COVID-19后并发症的发展监测。
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Immunopathologia Persa
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