Introduction: Increasing and maintaining bone density can play a role in preventing osteoporosis, as changes in the trabecular bone score (TBS) and bone mineral density (BMD) affect bone density, especially in the spine. Objectives: The present study aimed to determine the level of agreement between TBS and BMD in patients with osteoporosis and also to investigate the relationship between these two indices with body mass index (BMI). Patients and Methods: Data were collected from 843 patients, referred to the densitometry department of Resalat hospital. BMD and TBS were measured in the subjects to determine the risk of osteoporosis. The results of BMD were measured based on T-score level. The patients’ individual and clinical characteristics were also recorded and factors influencing the prognosis of density changes were evaluated. Moreover, the effect of BMI was investigated in this study. Results: The mean age of patients was 55.5 years. The kappa coefficient and Spearman’s correlation coefficient of BMD and TBS were 0.004 and -0.015, respectively. There was a significant correlation between BMI and BMD in men. The kappa coefficient gradually increased from normal bone density to osteoporosis. There was a significant negative correlation between BMI and BMD, while a significant positive correlation between height and BMD in women was existed. On the other hand, a significant negative correlation between weight and BMD was detected accordingly. Conclusion: According to the results of our study, there is no agreement between BMD and TBS.
{"title":"Investigation of the level of agreement between bone mineral density and trabecular bone score regarding gender, age and body mass index","authors":"Alireza Rajaei, Ideh Kamkar, F. Farsad","doi":"10.34172/ipp.2022.29296","DOIUrl":"https://doi.org/10.34172/ipp.2022.29296","url":null,"abstract":"Introduction: Increasing and maintaining bone density can play a role in preventing osteoporosis, as changes in the trabecular bone score (TBS) and bone mineral density (BMD) affect bone density, especially in the spine. Objectives: The present study aimed to determine the level of agreement between TBS and BMD in patients with osteoporosis and also to investigate the relationship between these two indices with body mass index (BMI). Patients and Methods: Data were collected from 843 patients, referred to the densitometry department of Resalat hospital. BMD and TBS were measured in the subjects to determine the risk of osteoporosis. The results of BMD were measured based on T-score level. The patients’ individual and clinical characteristics were also recorded and factors influencing the prognosis of density changes were evaluated. Moreover, the effect of BMI was investigated in this study. Results: The mean age of patients was 55.5 years. The kappa coefficient and Spearman’s correlation coefficient of BMD and TBS were 0.004 and -0.015, respectively. There was a significant correlation between BMI and BMD in men. The kappa coefficient gradually increased from normal bone density to osteoporosis. There was a significant negative correlation between BMI and BMD, while a significant positive correlation between height and BMD in women was existed. On the other hand, a significant negative correlation between weight and BMD was detected accordingly. Conclusion: According to the results of our study, there is no agreement between BMD and TBS.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"35 11","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138600630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malik Ayyad, Omar Ayaad, Hassan Alkhatatbeh, F. Sawaqed, Samer Al-Rawashdeh, Bayan Qaddumi
Introduction: Overactive bladder (OAB) is a common condition in urology that affects individuals of various ages and genders, significantly impacting their quality of life. Objectives: The study aimed to examine the effectiveness of gabapentin in treating OAB in Jordan. Patients and Methods: This study was conducted at a private clinic in Jordan between 2020 and 2022. It utilized a one-group pre- and post-test design involving 50 patients. The intervention involved administering gabapentin at a daily dose of 400 mg. The effectiveness of gabapentin was evaluated using the overactive bladder symptom score (OABSS) questionnaire, administered before and after six weeks of gabapentin administration. Results: The study sample consisted of 50 patients aged between 45 and 85 years, with a mean age of 65.2 years. After the treatment, all individual variables, such as urgency, frequency, nocturia, and urgency incontinence, showed significant reductions compared to the pre-intervention values. The mean total OABSS significantly decreased from 14.6 before to 6.8 after the intervention. The paired t test yielded a result of 9.84 with a P value of less than 0.001, indicating a statistically significant improvement. Conclusion: The noteworthy improvement in OABSS scores, urgency, nocturia, frequency of micturition, and urge incontinence observed in this study suggests that gabapentin could have a role as a treatment option for OAB patients.
{"title":"The effectiveness of gabapentin in treating overactive bladder: a quasi-experimental study","authors":"Malik Ayyad, Omar Ayaad, Hassan Alkhatatbeh, F. Sawaqed, Samer Al-Rawashdeh, Bayan Qaddumi","doi":"10.34172/ipp.2023.40574","DOIUrl":"https://doi.org/10.34172/ipp.2023.40574","url":null,"abstract":"Introduction: Overactive bladder (OAB) is a common condition in urology that affects individuals of various ages and genders, significantly impacting their quality of life. Objectives: The study aimed to examine the effectiveness of gabapentin in treating OAB in Jordan. Patients and Methods: This study was conducted at a private clinic in Jordan between 2020 and 2022. It utilized a one-group pre- and post-test design involving 50 patients. The intervention involved administering gabapentin at a daily dose of 400 mg. The effectiveness of gabapentin was evaluated using the overactive bladder symptom score (OABSS) questionnaire, administered before and after six weeks of gabapentin administration. Results: The study sample consisted of 50 patients aged between 45 and 85 years, with a mean age of 65.2 years. After the treatment, all individual variables, such as urgency, frequency, nocturia, and urgency incontinence, showed significant reductions compared to the pre-intervention values. The mean total OABSS significantly decreased from 14.6 before to 6.8 after the intervention. The paired t test yielded a result of 9.84 with a P value of less than 0.001, indicating a statistically significant improvement. Conclusion: The noteworthy improvement in OABSS scores, urgency, nocturia, frequency of micturition, and urge incontinence observed in this study suggests that gabapentin could have a role as a treatment option for OAB patients.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"21 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138602788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulhussain Kadhim Jwaziri, Maryam Esghaei, Mohammad Hadi Karbalaie Niya, Mohsen Mehrjoo, Hadi Abd Zaid Sayah, Hossein Keyvani
Introduction: Chronic hepatitis B (CHB) is a global concern due to its association with cirrhosis and hepatocellular carcinoma (HCC) development. The interplay between viral load, the immune system, and host factors is critical in tumorigenesis. Autophagy is a significant contributor to immune system function, since vitamin D plays an important role in this context. Objectives: The objective of this study was to assess the association between ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, viral load, and vitamin D with HBV pre-C/C mutations in Iraqi patients with CHB. Patients and Methods: In this cross-sectional study, a total of 134 CHB patients were evaluated for ATG polymorphisms, viral load, and vitamin D levels. Blood samples were collected after obtaining ethical consent, and the mutations were analyzed using polymerase chain reaction (PCR) followed by Sanger sequencing. Serum samples from CHB patients were used for viral load and vitamin D assessment. Results: The evaluation of patients revealed that 67 (44.6%) were male and 83 (55.4%) were female, with a mean age of 36±12.7 years and a mean duration of infection of 5.2±4.8 years. Mutations in pre-C/C were observed in 20% (27/134) of the patients. There was a significant association between all evaluated ATG polymorphisms and pre-C/C mutants (P<0.05). Furthermore, there was an association between viral load and mutations in pre-C/C (P=0.03), while no statistically significant difference was found between vitamin D levels and pre-core/core mutants or viral load. Conclusion: Our study demonstrates a higher frequency of ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, as well as a higher viral load in Iraqi CHB patients with HBV pre-C/C mutations.
{"title":"Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients","authors":"Abdulhussain Kadhim Jwaziri, Maryam Esghaei, Mohammad Hadi Karbalaie Niya, Mohsen Mehrjoo, Hadi Abd Zaid Sayah, Hossein Keyvani","doi":"10.34172/ipp.2023.40575","DOIUrl":"https://doi.org/10.34172/ipp.2023.40575","url":null,"abstract":"Introduction: Chronic hepatitis B (CHB) is a global concern due to its association with cirrhosis and hepatocellular carcinoma (HCC) development. The interplay between viral load, the immune system, and host factors is critical in tumorigenesis. Autophagy is a significant contributor to immune system function, since vitamin D plays an important role in this context. Objectives: The objective of this study was to assess the association between ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, viral load, and vitamin D with HBV pre-C/C mutations in Iraqi patients with CHB. Patients and Methods: In this cross-sectional study, a total of 134 CHB patients were evaluated for ATG polymorphisms, viral load, and vitamin D levels. Blood samples were collected after obtaining ethical consent, and the mutations were analyzed using polymerase chain reaction (PCR) followed by Sanger sequencing. Serum samples from CHB patients were used for viral load and vitamin D assessment. Results: The evaluation of patients revealed that 67 (44.6%) were male and 83 (55.4%) were female, with a mean age of 36±12.7 years and a mean duration of infection of 5.2±4.8 years. Mutations in pre-C/C were observed in 20% (27/134) of the patients. There was a significant association between all evaluated ATG polymorphisms and pre-C/C mutants (P<0.05). Furthermore, there was an association between viral load and mutations in pre-C/C (P=0.03), while no statistically significant difference was found between vitamin D levels and pre-core/core mutants or viral load. Conclusion: Our study demonstrates a higher frequency of ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, as well as a higher viral load in Iraqi CHB patients with HBV pre-C/C mutations.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Javad Sadeghi, Saba Bazzazi, Farinaz Fattahi, Moloud Alsadat Mousavi, Ardeshir Tajbakhsh, Sadaf Rassouli, Siavash Sangi, Mahshad Ghezelbash, Anna Ghorbani
Introduction: Ovarian cancer is the sixth leading cancer-related mortality cause in women worldwide. Analgesics may hinder the occurrence of ovarian cancer through inflammation relief. The present study seeks to examine the relationship between analgesic consumption and ovarian cancer risk through a systematic review and meta-analysis. Materials and Methods: PubMed, Scopus, Web of Science, Cochrane databases, and Google Scholar search engines were searched for works published by May 2023 using standard keywords to collect the required data sources. Acquired data were then analyzed in STATA version14, considering a significance level of P < 0.05 in statistical tests. Results: The present meta-analysis comprised 21 studies (14 case-control and 7 cohort studies) performed on 53,755 subjects. Results indicated that taking aspirin reduced the risk of ovarian cancer by 8% (OR: 0.92; 95% CI: 0.87, 0.98), whereas other non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) did not significantly affect the ovarian cancer risk (OR: 0.91; 95% CI: 0.81, 1.02). Similar results were observed in the case of ibuprofen and acetaminophen, with non-significant relationships between the risk of ovarian cancer and with the consumption of both acetaminophen (OR: 0.95; 95% CI: 0.84, 1.08) and ibuprofen (OR: 0.76; 95% CI: 0.50, 1.14). Furthermore, the duration of analgesic consumption was not significantly linked to the risk of ovarian cancer in the case of all studied drugs. Conclusion: Among aspirin, ibuprofen, acetaminophen, and non-aspirin NSAIDs, only aspirin was found to reduce the risk of ovarian cancer in women while the other studied drugs did not influence the studied risk. However, further research is recommended to confirm the results. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023434730) and Research Registry (UIN: reviewregistry1668) websites.
简介：癌症是全球第六大女性癌症相关死亡原因。镇痛药可能通过炎症缓解来阻碍卵巢癌症的发生。本研究旨在通过系统回顾和荟萃分析来检验镇痛药消耗与卵巢癌症风险之间的关系。材料和方法：PubMed、Scopus、Web of Science、Cochrane数据库和Google Scholar搜索引擎使用标准关键词搜索截至2023年5月发表的作品，以收集所需的数据源。然后在STATA版本14中分析所获得的数据，考虑到统计学检验中P<0.05的显著性水平。结果：本荟萃分析包括对53755名受试者进行的21项研究（14项病例对照研究和7项队列研究）。结果表明，服用阿司匹林可降低卵巢癌症风险8%（OR:0.92；95%CI:0.87，0.98），而其他非阿司匹林类非甾体抗炎药对卵巢癌症风险没有显著影响（OR:0.91；95%CI:0.81，1.02），卵巢癌症风险与对乙酰氨基酚（OR:0.95；95%CI:0.84，1.08）和布洛芬（OR:0.76；95%CI:0.50，1.14）的服用之间无显著关系。结论：在阿司匹林、布洛芬、对乙酰氨基酚和非阿司匹林类非甾体抗炎药中，只有阿司匹林能降低女性患卵巢癌症的风险，而其他研究药物对研究风险没有影响。然而，建议进行进一步的研究来证实这一结果。注册：本研究基于PRISMA检查表编制，其方案已在PROSPERO（CRD42023434730）和研究注册处（UIN:reviewregistry1668）网站上注册。
{"title":"Impact of analgesics on the risk of ovarian cancer; a systematic review and meta-analysis of cohort and case-control studies","authors":"Javad Sadeghi, Saba Bazzazi, Farinaz Fattahi, Moloud Alsadat Mousavi, Ardeshir Tajbakhsh, Sadaf Rassouli, Siavash Sangi, Mahshad Ghezelbash, Anna Ghorbani","doi":"10.34172/ipp.2023.40572","DOIUrl":"https://doi.org/10.34172/ipp.2023.40572","url":null,"abstract":"Introduction: Ovarian cancer is the sixth leading cancer-related mortality cause in women worldwide. Analgesics may hinder the occurrence of ovarian cancer through inflammation relief. The present study seeks to examine the relationship between analgesic consumption and ovarian cancer risk through a systematic review and meta-analysis. Materials and Methods: PubMed, Scopus, Web of Science, Cochrane databases, and Google Scholar search engines were searched for works published by May 2023 using standard keywords to collect the required data sources. Acquired data were then analyzed in STATA version14, considering a significance level of P < 0.05 in statistical tests. Results: The present meta-analysis comprised 21 studies (14 case-control and 7 cohort studies) performed on 53,755 subjects. Results indicated that taking aspirin reduced the risk of ovarian cancer by 8% (OR: 0.92; 95% CI: 0.87, 0.98), whereas other non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) did not significantly affect the ovarian cancer risk (OR: 0.91; 95% CI: 0.81, 1.02). Similar results were observed in the case of ibuprofen and acetaminophen, with non-significant relationships between the risk of ovarian cancer and with the consumption of both acetaminophen (OR: 0.95; 95% CI: 0.84, 1.08) and ibuprofen (OR: 0.76; 95% CI: 0.50, 1.14). Furthermore, the duration of analgesic consumption was not significantly linked to the risk of ovarian cancer in the case of all studied drugs. Conclusion: Among aspirin, ibuprofen, acetaminophen, and non-aspirin NSAIDs, only aspirin was found to reduce the risk of ovarian cancer in women while the other studied drugs did not influence the studied risk. However, further research is recommended to confirm the results. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023434730) and Research Registry (UIN: reviewregistry1668) websites.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44794728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ganesan Geethanjali, E. Ramprasad, Sekar Manikantan, M. Jayakumar
Introduction: It was essential to explore immunosuppressant management strategies and potential clinical variables associated with COVID-19 related mortality in order to provide insight for clinicians attempting to manage kidney transplant recipients during the ongoing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic. Objectives: The aim of the study was to assess the impact of COVID-19 on post-transplant renal function and outcome of immunosuppressant management on COVID-19. Patients and Methods: This is a cross sectional observational study conducted from March 2020 to January 2022 in a tertiary care hospital in South India. Baseline characteristics, comorbidities, history of graft dysfunction, symptoms and immunosuppressant modification was noted. Outcomes of COVID-19 such as acute kidney injury (AKI), need for dialysis and post COVID-19 complications were noted. The statistics were expressed as percentage for categorical variables and mean ± SD for continuous variables. Results: Out of 400 renal transplant patients on regular follow up, 28 patients developed COVID-19. The incidence of AKI was 64.2%. Immunosuppressant dose modification was done in majority of patients [mycophenolate mofetil (28.5%), steroids (53.5%) and tacrolimus (39.2%)]. Outcomes included recovery from AKI in 61.1%, recovery from oxygen dependence in 100% patients with an overall mortality rate of 7.1% patients. About 17.8% patients developed post-COVID-19 complications. Conclusion: Immunosuppressant dose modification during COVID-19 could play a role in development of AKI; infection being an independent risk factor. Patients should be monitored for development of post-COVID-19 complications.
{"title":"Impact of COVID-19 on renal transplant recipients","authors":"Ganesan Geethanjali, E. Ramprasad, Sekar Manikantan, M. Jayakumar","doi":"10.34172/ipp.2023.39489","DOIUrl":"https://doi.org/10.34172/ipp.2023.39489","url":null,"abstract":"Introduction: It was essential to explore immunosuppressant management strategies and potential clinical variables associated with COVID-19 related mortality in order to provide insight for clinicians attempting to manage kidney transplant recipients during the ongoing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic. Objectives: The aim of the study was to assess the impact of COVID-19 on post-transplant renal function and outcome of immunosuppressant management on COVID-19. Patients and Methods: This is a cross sectional observational study conducted from March 2020 to January 2022 in a tertiary care hospital in South India. Baseline characteristics, comorbidities, history of graft dysfunction, symptoms and immunosuppressant modification was noted. Outcomes of COVID-19 such as acute kidney injury (AKI), need for dialysis and post COVID-19 complications were noted. The statistics were expressed as percentage for categorical variables and mean ± SD for continuous variables. Results: Out of 400 renal transplant patients on regular follow up, 28 patients developed COVID-19. The incidence of AKI was 64.2%. Immunosuppressant dose modification was done in majority of patients [mycophenolate mofetil (28.5%), steroids (53.5%) and tacrolimus (39.2%)]. Outcomes included recovery from AKI in 61.1%, recovery from oxygen dependence in 100% patients with an overall mortality rate of 7.1% patients. About 17.8% patients developed post-COVID-19 complications. Conclusion: Immunosuppressant dose modification during COVID-19 could play a role in development of AKI; infection being an independent risk factor. Patients should be monitored for development of post-COVID-19 complications.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42763119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thymomas are rare tumors that can present with a wide range of clinical characteristics. The presence of symptoms and paraneoplastic syndromes, such as myasthenia gravis, along with the histological subtype and stage of the tumor, are important factors that guide the treatment approach and prognosis for patients with thymomas. The prognosis for thymoma varies depending on several factors, including the stage and type of the tumor, as well as the presence of associated autoimmune diseases. Generally, early-stage thymomas have a better prognosis compared to advanced-stage tumors. Regular follow-up with a multidisciplinary team, including oncologists and thoracic surgeons, is essential for long-term management and surveillance of patients.
{"title":"Thymoma; clinical presentations, pathology, and prognostic factors – a surgery point of view","authors":"H. Hemmati, M. Memarian","doi":"10.34172/ipp.2023.40581","DOIUrl":"https://doi.org/10.34172/ipp.2023.40581","url":null,"abstract":"Thymomas are rare tumors that can present with a wide range of clinical characteristics. The presence of symptoms and paraneoplastic syndromes, such as myasthenia gravis, along with the histological subtype and stage of the tumor, are important factors that guide the treatment approach and prognosis for patients with thymomas. The prognosis for thymoma varies depending on several factors, including the stage and type of the tumor, as well as the presence of associated autoimmune diseases. Generally, early-stage thymomas have a better prognosis compared to advanced-stage tumors. Regular follow-up with a multidisciplinary team, including oncologists and thoracic surgeons, is essential for long-term management and surveillance of patients.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49168390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Talakoub, Gholamreza Khalili, Hoda Sadat Rohani
Introduction: Postoperative pain control is one of the patient’s rights and the challenges of surgeons and anesthesiologists since about 20% of patients experience severe pain in the first 24 hours after surgery. Mastoidectomy and tympanoplasty are common surgeries in the head and neck area, in which profound and long-term analgesia is essential. Objectives: The present study investigated the effect of the combination of topical morphine, triamcinolone, and lidocaine compared to the control group. Patients and Methods: In the current clinical trial, 68 patients’ candidates for mastoidectomy-tympanoplasty surgery were included and randomly divided into intervention and control groups. The variables of demographic, pain, hemodynamics, extubation time, and received opioids were measured. Results: The results of the current study indicated a significant reduction in the patient’s pain scores in both groups (P=0.001), while the patients of group 1 had significantly lower pain scores than group 2 after 8, 12, and 24 hours in the ward (P<0.05). Moreover, a significant reduction was observed in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in all patients during surgery (P<0.001). However, in patients who received morphine, triamcinolone, and lidocaine (group 1), SBP and MAP were significantly lower than group 2 after 40, 80, 100, 120, 140, and 160 minutes during surgery (P<0.05). Conclusion: The present study indicated that the combination of morphine, triamcinolone, and lidocaine compared to the control group could lead to better pain control, further reduction of SBP and MAP, reduction of post-operative opioid use, and delay during the first opioid administration. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20200825048515N39; https://irct.ir/trial/57931, ethical code; IR.MUI.MED.REC.1400.064).
{"title":"Comparing the effect of local injection of combined morphine, triamcinolone and lidocaine and lidocaine injection on pain intensity after mastoidectomy-tympanoplasty; a triple-blind clinical trial","authors":"R. Talakoub, Gholamreza Khalili, Hoda Sadat Rohani","doi":"10.34172/ipp.2023.39525","DOIUrl":"https://doi.org/10.34172/ipp.2023.39525","url":null,"abstract":"Introduction: Postoperative pain control is one of the patient’s rights and the challenges of surgeons and anesthesiologists since about 20% of patients experience severe pain in the first 24 hours after surgery. Mastoidectomy and tympanoplasty are common surgeries in the head and neck area, in which profound and long-term analgesia is essential. Objectives: The present study investigated the effect of the combination of topical morphine, triamcinolone, and lidocaine compared to the control group. Patients and Methods: In the current clinical trial, 68 patients’ candidates for mastoidectomy-tympanoplasty surgery were included and randomly divided into intervention and control groups. The variables of demographic, pain, hemodynamics, extubation time, and received opioids were measured. Results: The results of the current study indicated a significant reduction in the patient’s pain scores in both groups (P=0.001), while the patients of group 1 had significantly lower pain scores than group 2 after 8, 12, and 24 hours in the ward (P<0.05). Moreover, a significant reduction was observed in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in all patients during surgery (P<0.001). However, in patients who received morphine, triamcinolone, and lidocaine (group 1), SBP and MAP were significantly lower than group 2 after 40, 80, 100, 120, 140, and 160 minutes during surgery (P<0.05). Conclusion: The present study indicated that the combination of morphine, triamcinolone, and lidocaine compared to the control group could lead to better pain control, further reduction of SBP and MAP, reduction of post-operative opioid use, and delay during the first opioid administration. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20200825048515N39; https://irct.ir/trial/57931, ethical code; IR.MUI.MED.REC.1400.064).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43404941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ahmadzadeh, M. Sheibani, F. Farsad, P. Dehghan, L. Gachkar, Samad Nazarpoor
Introduction: Systemic sclerosis (SSc) is an autoimmune disorder that often presents with skin involvement. SSc affects various organs, and one of the most important of these organs is the cardiovascular system, which is one of the complications of this syndrome, including pulmonary arterial hypertension (PAH). Early diagnosis of this complication is very important due to the importance of the effect of PAH on mortality and morbidity of patients. For diagnosis of PAH, two methods of computed tomography (CT) scan and echocardiography are conducted. Objectives: In this study, we aimed to evaluate the agreement coefficient of chest CT scan in comparison with echocardiography in the diagnosis of PAH in patients with SSc. Patients and Methods: In a diagnostic study, which was conducted in Loghman hospital (Tehran-Iran), patients with a diagnosis of SSc were evaluated for pulmonary artery pressure (PAP) by echocardiography. For patients, a CT scan of the lungs was conducted and PAP was assessed. The results that obtained from the lungs CT scan were compared with the echocardiography results. Results: Fifty patients with SSc were evaluated. Eighty-four percent of patients were female and the mean age of all patients was 48.94 ± 11.02 years. About 16% of all patients had high PAP based on echocardiography and 28% of patients based on CT scan. Kappa’s agreement coefficient was 0.428 and Spearman’s correlation coefficient was 0.457. In other words, chest CT scan has a partly agreement with the echocardiography method (P value = 0.001). Conclusion: Chest CT scan has a high sensitivity, specificity, and accuracy compared to echocardiography as a screening method.
{"title":"Evaluation of agreement coefficient between chest computed tomography and echocardiography in the diagnosis of pulmonary artery hypertension in patients with systemic sclerosis; a pilot study","authors":"A. Ahmadzadeh, M. Sheibani, F. Farsad, P. Dehghan, L. Gachkar, Samad Nazarpoor","doi":"10.34172/ipp.2023.34435","DOIUrl":"https://doi.org/10.34172/ipp.2023.34435","url":null,"abstract":"Introduction: Systemic sclerosis (SSc) is an autoimmune disorder that often presents with skin involvement. SSc affects various organs, and one of the most important of these organs is the cardiovascular system, which is one of the complications of this syndrome, including pulmonary arterial hypertension (PAH). Early diagnosis of this complication is very important due to the importance of the effect of PAH on mortality and morbidity of patients. For diagnosis of PAH, two methods of computed tomography (CT) scan and echocardiography are conducted. Objectives: In this study, we aimed to evaluate the agreement coefficient of chest CT scan in comparison with echocardiography in the diagnosis of PAH in patients with SSc. Patients and Methods: In a diagnostic study, which was conducted in Loghman hospital (Tehran-Iran), patients with a diagnosis of SSc were evaluated for pulmonary artery pressure (PAP) by echocardiography. For patients, a CT scan of the lungs was conducted and PAP was assessed. The results that obtained from the lungs CT scan were compared with the echocardiography results. Results: Fifty patients with SSc were evaluated. Eighty-four percent of patients were female and the mean age of all patients was 48.94 ± 11.02 years. About 16% of all patients had high PAP based on echocardiography and 28% of patients based on CT scan. Kappa’s agreement coefficient was 0.428 and Spearman’s correlation coefficient was 0.457. In other words, chest CT scan has a partly agreement with the echocardiography method (P value = 0.001). Conclusion: Chest CT scan has a high sensitivity, specificity, and accuracy compared to echocardiography as a screening method.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69814716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahnaz Eskandari, Nasim Shabani, A. Baradaran, S. Mobasherizadeh, S. Rostami, M. Derakhshan
Introduction: This study compared phenotypic methods and the 16S rRNA gene sequencing method to identify the genus and species of non-fermenting gram-negative bacilli isolated from blood culture samples. Objectives: The aim of this study was to evaluate the effectiveness of using the 16S rRNA gene sequencing method in detecting the genus and species of non-fermented gram-negative bacteria isolated from blood samples. Materials and Methods: A cross-sectional study was conducted from April 2019 to April 2020, including all patients who required sterile culture at AL Zahra and Kashani hospitals. Specimens were cultured in BACTEC and subjected to standard phenotypic methods. Subsequently, 16S rRNA gene sequencing was performed to detect gram-negative non-fermenting Bacillus bacteria at the genus and species level. A comparative evaluation was then conducted. Results: The study identified 30 bacteria. The 16S rRNA gene sequencing method observed that 83.3% of the diagnoses were Acinetobacter baumannii, while the phenotypic approach identified 86.7% as Acinetobacter. Conclusion: The results indicate a significant difference between the phenotypic method and 16S rRNA sequencing in detecting non-fermenting gram-negative bacilli (NFGNB).
{"title":"The comparative survey of phenotypic methods and the 16S rRNA gene sequencing method for detecting genus and species of non-fermented gram-negative bacteria isolated from blood samples in Isfahan, Iran","authors":"Shahnaz Eskandari, Nasim Shabani, A. Baradaran, S. Mobasherizadeh, S. Rostami, M. Derakhshan","doi":"10.34172/ipp.2023.39481","DOIUrl":"https://doi.org/10.34172/ipp.2023.39481","url":null,"abstract":"Introduction: This study compared phenotypic methods and the 16S rRNA gene sequencing method to identify the genus and species of non-fermenting gram-negative bacilli isolated from blood culture samples. Objectives: The aim of this study was to evaluate the effectiveness of using the 16S rRNA gene sequencing method in detecting the genus and species of non-fermented gram-negative bacteria isolated from blood samples. Materials and Methods: A cross-sectional study was conducted from April 2019 to April 2020, including all patients who required sterile culture at AL Zahra and Kashani hospitals. Specimens were cultured in BACTEC and subjected to standard phenotypic methods. Subsequently, 16S rRNA gene sequencing was performed to detect gram-negative non-fermenting Bacillus bacteria at the genus and species level. A comparative evaluation was then conducted. Results: The study identified 30 bacteria. The 16S rRNA gene sequencing method observed that 83.3% of the diagnoses were Acinetobacter baumannii, while the phenotypic approach identified 86.7% as Acinetobacter. Conclusion: The results indicate a significant difference between the phenotypic method and 16S rRNA sequencing in detecting non-fermenting gram-negative bacilli (NFGNB).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69815261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahnaz Eskandari, E. Amini, A. Baradaran, S. Mobasherizadeh, S. Rostami, M. Derakhshan
Introduction: A comparative study was conducted to identify the genus and species of non-fermenting gram-negative bacilli isolated from blood culture samples using phenotypic methods and the Phoenix method. Objectives: This study aimed to evaluate the Phoenix system compared to the currently available phenotypic process. Materials and Methods: This descriptive-analytical cross-sectional study evaluated 30 samples collected from 2019 to 2020 from patients at AL Zahra and Kashani hospitals who required blood cultures. The specimens were injected into BACTEC™. Positive cultures identified as non-fermenting gram-negative bacteria by the phenotypic method were included in the study and then evaluated using the Phoenix method to determine the genus and species of non-fermenting gram-negative bacteria. A comparison was then conducted. Results: The study identified 30 non-fermenting gram-negative bacteria. The Phoenix method revealed that 78.5% of the diagnoses were Acinetobacter, while the phenotypic approach identified 86.7% as Acinetobacter spp. Conclusion: The present study demonstrated a significant difference between the Phoenix and phenotypic methods in identifying the type of bacteria.
{"title":"The comparative survey of phenotypic methods and the BD Phoenix M50 automated microbiology system for detecting the genus of non-fermenting gram-negative bacteria isolated from blood samples in Isfahan, Iran","authors":"Shahnaz Eskandari, E. Amini, A. Baradaran, S. Mobasherizadeh, S. Rostami, M. Derakhshan","doi":"10.34172/ipp.2023.39483","DOIUrl":"https://doi.org/10.34172/ipp.2023.39483","url":null,"abstract":"Introduction: A comparative study was conducted to identify the genus and species of non-fermenting gram-negative bacilli isolated from blood culture samples using phenotypic methods and the Phoenix method. Objectives: This study aimed to evaluate the Phoenix system compared to the currently available phenotypic process. Materials and Methods: This descriptive-analytical cross-sectional study evaluated 30 samples collected from 2019 to 2020 from patients at AL Zahra and Kashani hospitals who required blood cultures. The specimens were injected into BACTEC™. Positive cultures identified as non-fermenting gram-negative bacteria by the phenotypic method were included in the study and then evaluated using the Phoenix method to determine the genus and species of non-fermenting gram-negative bacteria. A comparison was then conducted. Results: The study identified 30 non-fermenting gram-negative bacteria. The Phoenix method revealed that 78.5% of the diagnoses were Acinetobacter, while the phenotypic approach identified 86.7% as Acinetobacter spp. Conclusion: The present study demonstrated a significant difference between the Phoenix and phenotypic methods in identifying the type of bacteria.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42463446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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