Development of Sunscreen Containing Alpha-Mangostin Riched Extract with Anti-Tyrosinase Activities

P. Tangyuenyongwatana, W. Gritsanapan
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Abstract

Abstract This study focused on the development of extracts from mangosteen rinds for use as whitening and sunscreen agents. Mangosteen rinds were obtained from 9 locations in the East and the South of Thailand. Ethanol (95%) crude rind extracts were prepared and separated by column chromatography. The fractions were collected from top (F1-F4) and mid spots (F12-F15). These fractions were subjected to tyrosinase inhibitory activity assay and found that the top spot exhibited low activity with IC50 > 100 µg/mL while the mid spots inhibited tyrosinase enzyme at IC50 18.48 µg/mL which is more sensitive than a positive control, kojic acid (38.46 µg/mL). The mid spots fraction from the crude extract of Chanthaburi sample 1 was analyzed with HPLC and was assigned as MGS-1 extract which contained a high amount of α-mangostin. MGS-1 extract was formulated as oil in water cream with 2, 4, 6, and 9 %w/w extract. All creams were subjected to measure SPF and UVA/UVB ratio using an Optometrics SPF-290S analyzer. It was found that the cream with 6 %w/w MGS-1 extract showed the best results with SPF at 10.36 ± 1.07 and had a UVA/UVB ratio equal to 0.451. These sunscreen properties are close to the properties of Salisol-3 (benzophenone), a standard sunscreen. In conclusion, MGS-1 extract has a good potential to be used as a whitening and sunscreen agent in cosmetics with a lower cost of substrate because mangosteen rinds can be found as waste from eating mangosteen fruit every year in Thailand. Keywords: Mangosteen rind, MGS-1 extract, Tyrosinase inhibition, Whitening agent, Sunscreen
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具有抗酪氨酸酶活性的富含α -山竹苷提取物防晒霜的研制
摘要:本研究主要研究山竹果皮提取物的开发及其在美白和防晒方面的应用。山竹果皮是从泰国东部和南部的9个地点获得的。制备乙醇(95%)粗果皮提取物,采用柱层析法进行分离。从顶部(F1-F4)和中间(F12-F15)处采集馏分。结果表明,顶端对酪氨酸酶的抑制活性较低,IC50为100µg/mL,而中间对酪氨酸酶的抑制活性为18.48µg/mL,比阳性对照曲酸(38.46µg/mL)更敏感。采用高效液相色谱法对竹竹样品1粗提物中斑点部位进行分析,确定其为含有高含量α-山竹苷的MGS-1提取物。MGS-1提取物分别以2、4、6、9% w/w的提取物配制成水膏油。使用Optometrics SPF- 290s分析仪测量所有面霜的SPF和UVA/UVB比率。结果表明,添加6% w/w MGS-1提取物的乳膏效果最佳,防晒系数为10.36±1.07,UVA/UVB比值为0.451。这些防晒性能接近salsol -3(二苯甲酮)的性能,这是一种标准的防晒霜。综上所述,MGS-1提取物具有良好的潜力,可以作为化妆品中的美白和防晒剂,并且基质成本较低,因为泰国每年食用山竹果的废料中都可以找到山竹皮。关键词:山竹果皮,MGS-1提取物,酪氨酸酶抑制,增白剂,防晒霜
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来源期刊
Chiang Mai University journal of natural sciences
Chiang Mai University journal of natural sciences Health Professions-Health Professions (miscellaneous)
CiteScore
1.70
自引率
0.00%
发文量
67
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