Menavath Tulasi Naik Ram, Sai Kushal Gunturu, A. Shaik, Yadlapalli Jaya Prasanth Babu, Sardena Siyonu Kumari
{"title":"Studies of Antibacterial Activity of the Seed Extract of Solanum surattense Burm. F .","authors":"Menavath Tulasi Naik Ram, Sai Kushal Gunturu, A. Shaik, Yadlapalli Jaya Prasanth Babu, Sardena Siyonu Kumari","doi":"10.18579/jopcr/v21i4.22.24","DOIUrl":null,"url":null,"abstract":"Crude Flavonoids extracted from crushed seeds of dried ripe fruits of Solanum surattense Burm F. were screened for antimicrobial activity against two bacteria – Streptococcus mutans and Aggregatibacter actinomycetemcomitans – which were found to be major contributers for occurrence of Dental caries. Minimum inhibitory concentration, Minimum bactericidal concentration, and Time Kill curve of the extract against each sensitive test pathogen, were evaluated. The flavonoid extract showed good antimicrobial activity against Streptococcus mutans than towards Aggregatibacter actinomycetemcomitans. MIC & MBC of Streptococcus mutans is 25µg/mL & 25µg/mL respectively. MIC & MBC of Aggregatibacter actinomycetemcomitans is 50µg/mL & 50µg/mL respectively. Time Kill Curve of Streptococcus mutans and Aggregatibacter actinomycetemcomitans was 2hr and 2hr respectively. Keywords: Solanum surattense, Streptococcus mutans, Aggregatibacter actinomycetemcomitans, Minimum inhibitory concentration, Minimum bactericidal concentration, Time kill curve","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18579/jopcr/v21i4.22.24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Crude Flavonoids extracted from crushed seeds of dried ripe fruits of Solanum surattense Burm F. were screened for antimicrobial activity against two bacteria – Streptococcus mutans and Aggregatibacter actinomycetemcomitans – which were found to be major contributers for occurrence of Dental caries. Minimum inhibitory concentration, Minimum bactericidal concentration, and Time Kill curve of the extract against each sensitive test pathogen, were evaluated. The flavonoid extract showed good antimicrobial activity against Streptococcus mutans than towards Aggregatibacter actinomycetemcomitans. MIC & MBC of Streptococcus mutans is 25µg/mL & 25µg/mL respectively. MIC & MBC of Aggregatibacter actinomycetemcomitans is 50µg/mL & 50µg/mL respectively. Time Kill Curve of Streptococcus mutans and Aggregatibacter actinomycetemcomitans was 2hr and 2hr respectively. Keywords: Solanum surattense, Streptococcus mutans, Aggregatibacter actinomycetemcomitans, Minimum inhibitory concentration, Minimum bactericidal concentration, Time kill curve
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