Pub Date : 2023-10-09DOI: 10.18579/jopcr/v22.2.23.19
Meghna ., Lalit Nagar, Ringzin Lamo, Kamal Nayan Dwivedi
Hypothyroidism is the significant endocrine problem found in general public. It is characterized by insufficient production of thyroid hormones, leading to abnormal levels. This condition prompts the decrease in Basal metabolic rate of the body. Ayurveda places a significant part to preclude the basic reason and to treat it. In Ayurveda, it tends to be associated with Kapha-vata dosha dushti, Rasavaha Strotasadushti, Medadushti and Agnimandya. In present study, a 22 years old female patient suffering from Sthaulya (~Weight gain), Duarbalya (~Weakness), Twak rukshata (~Dry skin), Kesh patana (hair loss), puffiness around eyes, mood swings, impaired memory, emotional depression, drowsiness, headache, Amalapitta (~Hyperacidity) and lethargy from last three years. She had been taking allopathic medicine without experiencing any satisfactory relief in her symptoms. In the present study, group of Herbo-mineral preparation was prescribed to the patient for a period of 4 months. After four months patient experienced relief, and her allopathic medicine was completely stopped. Keywords: Hypothyroidism, Agnimandya, Sthaulya
{"title":"Ayurvedic Management of Hypothyroidism - A Case Report","authors":"Meghna ., Lalit Nagar, Ringzin Lamo, Kamal Nayan Dwivedi","doi":"10.18579/jopcr/v22.2.23.19","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.19","url":null,"abstract":"Hypothyroidism is the significant endocrine problem found in general public. It is characterized by insufficient production of thyroid hormones, leading to abnormal levels. This condition prompts the decrease in Basal metabolic rate of the body. Ayurveda places a significant part to preclude the basic reason and to treat it. In Ayurveda, it tends to be associated with Kapha-vata dosha dushti, Rasavaha Strotasadushti, Medadushti and Agnimandya. In present study, a 22 years old female patient suffering from Sthaulya (~Weight gain), Duarbalya (~Weakness), Twak rukshata (~Dry skin), Kesh patana (hair loss), puffiness around eyes, mood swings, impaired memory, emotional depression, drowsiness, headache, Amalapitta (~Hyperacidity) and lethargy from last three years. She had been taking allopathic medicine without experiencing any satisfactory relief in her symptoms. In the present study, group of Herbo-mineral preparation was prescribed to the patient for a period of 4 months. After four months patient experienced relief, and her allopathic medicine was completely stopped. Keywords: Hypothyroidism, Agnimandya, Sthaulya","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135094736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Even three years after the COVID-19 pandemic initially appeared in December of the year 2019, it is still raging over the globe. There have been numerous attempts to use well-known medications in new ways to treat COVID-19 infection. Many nations, including India, implemented a series of lock downs in an effort to limit the pandemic. Sanitation practices, social seclusion, routine mask wearing, testing, and quarantining of suspected carriers were among the recommended methods for limiting the illness. Numerous treatment strategies have also been used to prevent and treat the illness, but no formal studies using well-known Ayurvedic formulations or any polyherbal combinations have been conducted. A clinical study was planned to test the noble polyherbal combination containing Withania somnifera, Tinospora cordifolia, Moringa oleifera, Adhatoda vasica, Piper longum, Glycyrrhiza glabra, Ocimum sanctum and Curcuma longa. The study checked the rate of symptom remission in individuals receiving the polyherbal combination in addition to standard of care (SoC) to that in patients with mild and moderate symptoms of COVID-19 infections receiving SoC alone. A prospective randomized interventional clinical study was planned comparing outcomes in 2 cohorts with mild to moderate COVID-19 as under. Cohort-1 was trialled with conventional treatment as per government advisory. Cohort-2 was trialled with polyherbal combination and with conventional treatment as per government advisory. With the current add-on Polyherbal regimen, an early clinical improvement in breathlessness was seen along with early ageusia and cough reduction when compared with conventional treatment. The polyherbal combination (KNDBHU) enhanced recovery in COVID-19 Patients. Given the lack of hospital beds in India, the median length of hospital stays was shortened; this development is significant. Keywords: Covid19, Add on polyherbal combinationregimen for Corona virus, Early Clinical Improvement, Shortened hospital stays
{"title":"Clinical Study and Assessment of Efficacy of Polyherbal Combination (KNDBHU) in COVID 19 Patients","authors":"Kamal Nayan Dwivedi, Poonam Sharma, Daneshwari Kanashetti, Meghna ., Lalit Nagar","doi":"10.18579/jopcr/v22.2.ms230502","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.ms230502","url":null,"abstract":"Even three years after the COVID-19 pandemic initially appeared in December of the year 2019, it is still raging over the globe. There have been numerous attempts to use well-known medications in new ways to treat COVID-19 infection. Many nations, including India, implemented a series of lock downs in an effort to limit the pandemic. Sanitation practices, social seclusion, routine mask wearing, testing, and quarantining of suspected carriers were among the recommended methods for limiting the illness. Numerous treatment strategies have also been used to prevent and treat the illness, but no formal studies using well-known Ayurvedic formulations or any polyherbal combinations have been conducted. A clinical study was planned to test the noble polyherbal combination containing Withania somnifera, Tinospora cordifolia, Moringa oleifera, Adhatoda vasica, Piper longum, Glycyrrhiza glabra, Ocimum sanctum and Curcuma longa. The study checked the rate of symptom remission in individuals receiving the polyherbal combination in addition to standard of care (SoC) to that in patients with mild and moderate symptoms of COVID-19 infections receiving SoC alone. A prospective randomized interventional clinical study was planned comparing outcomes in 2 cohorts with mild to moderate COVID-19 as under. Cohort-1 was trialled with conventional treatment as per government advisory. Cohort-2 was trialled with polyherbal combination and with conventional treatment as per government advisory. With the current add-on Polyherbal regimen, an early clinical improvement in breathlessness was seen along with early ageusia and cough reduction when compared with conventional treatment. The polyherbal combination (KNDBHU) enhanced recovery in COVID-19 Patients. Given the lack of hospital beds in India, the median length of hospital stays was shortened; this development is significant. Keywords: Covid19, Add on polyherbal combinationregimen for Corona virus, Early Clinical Improvement, Shortened hospital stays","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135096752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
11 commonly used Cephalosporin drugs from 1st, 2nd & 3rd Generation in wastewater from Cephalosporin Antibiotics Manufacturing plant is developed, validated and proposed for routine analysis of wastewater collected from waste water pre-treatment plant (wwptp). The determined residues included the routinely manufactured cephalosporin drugs for the treatment as β-Lactams Antibiotic drugs like Cefepime, Cefadroxil, Ceftazidime, Cephradine, Cefaclor, Cefotaxime, Ceftibuten, Ceftriaxone, Cefixime, Cefuroxime Axetil and Cefpodoxime proxetil. A gradient program was developed with Xterra RP-18 (250 cm x 4.6 mm, 5 µm) column as stationary phase. All cephalosporin molecules were selective and separated with a 0.2 M Tetra-butyl Ammonium Hydroxide (TBAH) buffer and Acetonitrile in the ratio of 85:15 V/V (Solution-A) and 25:75 V/V (Solution-B), pH 6.8 was adjusted with O-phosphoric acid into the buffer solution as the mobile phase at flow of 1.2 mL min- 1 with a UV detection at 254 nm using DAD. All peaks eluted within 60 minutes gradient run. The system suitability parameters such as theoretical plate count, tailing and resolution between the closest peaks were within the limit. The method was validated following all criteria regarding ICH (Q2) guidelines. Calibrations were linear over the concentration range of 0.5–150 µg mL-1 as indicated by correlation coefficient (r) of 0.999. The developed method can be the tool for determining the Cephalosporins residue as routine quantitative analysis of waste water discharged from the Antibiotic manufacturing plant. Keywords: Cephalosporins, Waste water, Method validation, Antibiotic Resistance, Antibiotic manufacturing plant
11种常用头孢菌素类药物从1、2和amp;开发、验证并提出了头孢菌素类抗生素生产厂废水中第三代的常规分析方法，用于废水预处理厂(wwptp)收集的废水。残留包括常规生产的用于β-内酰胺类治疗的头孢菌素类药物，如头孢吡肟、头孢羟肟、头孢他啶、头孢定、头孢克洛、头孢噻肟、头孢布丁、头孢曲松、头孢克肟、头孢呋辛酯和头孢多辛酯。以Xterra RP-18 (250 cm x 4.6 mm, 5µm)柱为固定相，建立梯度程序。所有头孢菌素分子都是选择性的，用0.2 M四丁基氢氧化铵(TBAH)缓冲液和乙腈，以85:15 V/V(溶液- a)和25:75 V/V(溶液-b)的比例分离，用o -磷酸调节pH 6.8作为缓冲液的流动相，流速为1.2 mL min- 1, DAD紫外检测254 nm。所有峰在60分钟内洗脱。理论板数、尾砂、近峰间分辨率等系统适宜性参数均在限定范围内。该方法按照ICH (Q2)指南的所有标准进行验证。相关系数(r)为0.999，在0.5 ~ 150µg mL-1的浓度范围内呈线性关系。该方法可作为抗生素生产企业废水中头孢菌素残留的常规定量分析工具。关键词:头孢菌素，废水，方法验证，抗生素耐药性，抗生素生产厂
{"title":"Simultaneous Determination of 11 Commonly used Cephalosporin Antibiotics Residue by High Performance Liquid Chromatography - Diode Array Detectors in Pharmaceutical Waste Water - A Tool for Controlling One of the Source of Antibiotic Resistance","authors":"Mohabbat Ullah, Md. Sohel Rana, Md. Monjil Hossain","doi":"10.18579/jopcr/v22.2.23.10","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.10","url":null,"abstract":"11 commonly used Cephalosporin drugs from 1st, 2nd & 3rd Generation in wastewater from Cephalosporin Antibiotics Manufacturing plant is developed, validated and proposed for routine analysis of wastewater collected from waste water pre-treatment plant (wwptp). The determined residues included the routinely manufactured cephalosporin drugs for the treatment as β-Lactams Antibiotic drugs like Cefepime, Cefadroxil, Ceftazidime, Cephradine, Cefaclor, Cefotaxime, Ceftibuten, Ceftriaxone, Cefixime, Cefuroxime Axetil and Cefpodoxime proxetil. A gradient program was developed with Xterra RP-18 (250 cm x 4.6 mm, 5 µm) column as stationary phase. All cephalosporin molecules were selective and separated with a 0.2 M Tetra-butyl Ammonium Hydroxide (TBAH) buffer and Acetonitrile in the ratio of 85:15 V/V (Solution-A) and 25:75 V/V (Solution-B), pH 6.8 was adjusted with O-phosphoric acid into the buffer solution as the mobile phase at flow of 1.2 mL min- 1 with a UV detection at 254 nm using DAD. All peaks eluted within 60 minutes gradient run. The system suitability parameters such as theoretical plate count, tailing and resolution between the closest peaks were within the limit. The method was validated following all criteria regarding ICH (Q2) guidelines. Calibrations were linear over the concentration range of 0.5–150 µg mL-1 as indicated by correlation coefficient (r) of 0.999. The developed method can be the tool for determining the Cephalosporins residue as routine quantitative analysis of waste water discharged from the Antibiotic manufacturing plant. Keywords: Cephalosporins, Waste water, Method validation, Antibiotic Resistance, Antibiotic manufacturing plant","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nephropathy is considered as one of the major secondary complications in diabetic patients. The goal of the current study was to perform preclinical screening of virgin coconut oil (VCO) solubilised curcumin in diabetes-induced nephropathy. Male albino rats of the Wistar strain were injected with a single dose of streptozotocin (STZ) (60 mg/kg/i.p). Diabetic nephropathy (DN) was developed after 4 weeks of STZ injection and the treatment was continued for further 4 weeks (i.e 8 weeks). DN rats were treated with VCO (8ml), VCO solubilised curcumin at a low dose (0.66mg/4ml/kg) and high dose (1.32mh/8ml/kg). DN was assessed by evaluating biochemical parameters such as blood glucose, total protein, albumin, urea, creatinine, and total bilirubin from serum and urine sample, whereas the activity of endogenous antioxidant and membrane- bound phosphatases were studied from kidney homogenate. VCO-solubilised curcumin significantly reduced blood and urine glucose level, increased body weight and reduced kidney weight and kidney hypertrophy. It also normalized urine volume, albumin, creatinine, total protein, total bilirubin and urea levels. Treatment also significantly improved antioxidants and membrane-bound phosphatase activities. In conclusion, compared to the individual treatment group, VCO solubilized curcumin significantly modifies the altered parameters toward normal. The potent antioxidant activity of these substances may be to blame for this defense. Keywords: Virgin coconut oil, curcumin, diabetes, nephropathy, antioxidants
{"title":"Virgin Coconut Oil Solubilised Curcumin Protects Nephropathy in Diabetic Rats","authors":"Pradnya Jadhav, Gaurav Kasar, Pooja Rasal, Manoj Mahajan, Aman Upaganlawa, Chandrashekhar Upasani","doi":"10.18579/jopcr/v22.2.23.22","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.22","url":null,"abstract":"Nephropathy is considered as one of the major secondary complications in diabetic patients. The goal of the current study was to perform preclinical screening of virgin coconut oil (VCO) solubilised curcumin in diabetes-induced nephropathy. Male albino rats of the Wistar strain were injected with a single dose of streptozotocin (STZ) (60 mg/kg/i.p). Diabetic nephropathy (DN) was developed after 4 weeks of STZ injection and the treatment was continued for further 4 weeks (i.e 8 weeks). DN rats were treated with VCO (8ml), VCO solubilised curcumin at a low dose (0.66mg/4ml/kg) and high dose (1.32mh/8ml/kg). DN was assessed by evaluating biochemical parameters such as blood glucose, total protein, albumin, urea, creatinine, and total bilirubin from serum and urine sample, whereas the activity of endogenous antioxidant and membrane- bound phosphatases were studied from kidney homogenate. VCO-solubilised curcumin significantly reduced blood and urine glucose level, increased body weight and reduced kidney weight and kidney hypertrophy. It also normalized urine volume, albumin, creatinine, total protein, total bilirubin and urea levels. Treatment also significantly improved antioxidants and membrane-bound phosphatase activities. In conclusion, compared to the individual treatment group, VCO solubilized curcumin significantly modifies the altered parameters toward normal. The potent antioxidant activity of these substances may be to blame for this defense. Keywords: Virgin coconut oil, curcumin, diabetes, nephropathy, antioxidants","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The liver is known for synthesising enzymes, metabolism, and excretion of drugs and food. However, during biological processes, the abnormality occurs in the liver, which becomes a significant global health burden in humans, characterised by loss of synthetic function, breakdown of blood, irregular vitamin K, and localised, permanent changes to parenchymal cells. The study was designed to research the Phytochemical and biological screening of Sicyos edulis leaf for hepatoprotective activity on laboratory animals using paracetamol and methotrexate model for acute incidence. The study evaluated liver toxicity in healthy Wistar albino rats using two in vivo models. Each study group consists of six animals. In the first model, paracetamol p.o. for seven days. Similarly, in the second model, methotrexate was administered (single dose treatment) to animals with 20mg/kg, b.w., p.o. Both models were challenged with methanolic extract of Sicyos edulis leaf (MESEL) of doses 100mg/kg (low) and 200 mg/kg (high) p.o. for seven days, respectively. On day 8th, the blood samples were collected from the tail vein and analysed for various biochemical parameters. MESEL successfully restored the elevated serum biomarker levels in our study. The decrease in aspartate aminotransferase was observed by removing toxic metabolites, the reduction in alanine aminotransferase was due to an increase in ATP synthesis in mitochondria, thereby modulating the balance of liver energy metabolism, and the decrease in alkaline phosphates is due to tissue regeneration, an increase in total protein denotes the restoration of protein imbalance from acute liver injury. At different concentrations, all these effects strengthen the liver, regulate body metabolism, and ultimately inhibit further liver cell damage in favour of their regeneration. Our study also evidences the protective action of MESEL in rats against the Paracetamol and methotrexate model. The study reveals hepatocyte regeneration followed by hepatic restoration in pre-clinical settings. Keywords: Acute liver disease, Sicyos edulis, Silymarin, Methotrexate, Liver enzymes
{"title":"In-vivo Hepatoprotective Evaluation of Sicyos edulis on Wistar Albino Rats","authors":"Karisma Borah, Devid Chutia, Manodeep Chakraborty, Ananya Bhattacharjee, Nihar Ranjan Bhuyan","doi":"10.18579/jopcr/v22.2.23.34","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.34","url":null,"abstract":"The liver is known for synthesising enzymes, metabolism, and excretion of drugs and food. However, during biological processes, the abnormality occurs in the liver, which becomes a significant global health burden in humans, characterised by loss of synthetic function, breakdown of blood, irregular vitamin K, and localised, permanent changes to parenchymal cells. The study was designed to research the Phytochemical and biological screening of Sicyos edulis leaf for hepatoprotective activity on laboratory animals using paracetamol and methotrexate model for acute incidence. The study evaluated liver toxicity in healthy Wistar albino rats using two in vivo models. Each study group consists of six animals. In the first model, paracetamol p.o. for seven days. Similarly, in the second model, methotrexate was administered (single dose treatment) to animals with 20mg/kg, b.w., p.o. Both models were challenged with methanolic extract of Sicyos edulis leaf (MESEL) of doses 100mg/kg (low) and 200 mg/kg (high) p.o. for seven days, respectively. On day 8th, the blood samples were collected from the tail vein and analysed for various biochemical parameters. MESEL successfully restored the elevated serum biomarker levels in our study. The decrease in aspartate aminotransferase was observed by removing toxic metabolites, the reduction in alanine aminotransferase was due to an increase in ATP synthesis in mitochondria, thereby modulating the balance of liver energy metabolism, and the decrease in alkaline phosphates is due to tissue regeneration, an increase in total protein denotes the restoration of protein imbalance from acute liver injury. At different concentrations, all these effects strengthen the liver, regulate body metabolism, and ultimately inhibit further liver cell damage in favour of their regeneration. Our study also evidences the protective action of MESEL in rats against the Paracetamol and methotrexate model. The study reveals hepatocyte regeneration followed by hepatic restoration in pre-clinical settings. Keywords: Acute liver disease, Sicyos edulis, Silymarin, Methotrexate, Liver enzymes","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer is one of the most common cancers in women all around the world and is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and resistance and are found to be ineffective in patients. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective and efficient methods of cancer treatment. Phytochemicals are directly involved in treatment or precursors to synthesize useful drugs. Therefore, in the current investigation, 500 terpenoid phytoconstituents and five proteins associated with breast cancer including EGFR, ERα, HER2, NF-κB and Topo IIa were selected from various databases. Selected compounds were screened for their molecular properties based on Lipinski's rule of five resulting in 235 compounds exclusion. Drug-likeness and PAINS alert properties were predicted using pkCSM and SwissADME web servers which led to the omission of 43 compounds. The remaining 222 compounds were screened to predict their ADMET properties and based on these results, 117 compounds were selected to predict the anti-breast cancer potential. Finally, 73 compounds, which showed anti-breast cancer activity prediction, were virtually screened and the top four best-scoring compounds were selected as lead-like molecules and docked with the five respective breast cancer targets. The results showed that the top four lead-like molecules exhibited greater binding affinity and lesser toxicity than the standard drugs namely 4–Hydroxytamoxifen, Daunorubicin, Erlotinib and Lapatinib. Keywords: ADMET, Breast cancer, Chemotherapeutic agents, In silico analysis, Molecular docking, Terpenoids
{"title":"Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach","authors":"Senthil Kumar Raju, Shridharshini Kumar, Praveen Sekar, Naveena Sundhararajan, Yogadharshini Nagalingam","doi":"10.18579/jopcr/v22.2.23.5","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.5","url":null,"abstract":"Breast cancer is one of the most common cancers in women all around the world and is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and resistance and are found to be ineffective in patients. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective and efficient methods of cancer treatment. Phytochemicals are directly involved in treatment or precursors to synthesize useful drugs. Therefore, in the current investigation, 500 terpenoid phytoconstituents and five proteins associated with breast cancer including EGFR, ERα, HER2, NF-κB and Topo IIa were selected from various databases. Selected compounds were screened for their molecular properties based on Lipinski's rule of five resulting in 235 compounds exclusion. Drug-likeness and PAINS alert properties were predicted using pkCSM and SwissADME web servers which led to the omission of 43 compounds. The remaining 222 compounds were screened to predict their ADMET properties and based on these results, 117 compounds were selected to predict the anti-breast cancer potential. Finally, 73 compounds, which showed anti-breast cancer activity prediction, were virtually screened and the top four best-scoring compounds were selected as lead-like molecules and docked with the five respective breast cancer targets. The results showed that the top four lead-like molecules exhibited greater binding affinity and lesser toxicity than the standard drugs namely 4–Hydroxytamoxifen, Daunorubicin, Erlotinib and Lapatinib. Keywords: ADMET, Breast cancer, Chemotherapeutic agents, In silico analysis, Molecular docking, Terpenoids","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.18579/jopcr/v22.2.23.42
Sivaramakrishna Valluru, C Srikanth Reddy, Shanmukha Srinivasulu Udayagiri, Sada Surya Vidavaluru
Breast cancer is the most common malignant tumor and leading cause of death in women worldwide. It accounts for 15% of all cancer deaths According to World Health Organisation (WHO), approximately 70% of breast malignancies occur in women with unknown risk factorsThe prognostic factor can be defined as a measurable variable which correlates with natural history of the disease. The most significant factor which influences prognosis in breast cancer is axillary lymph node involvement, which is usually assessed at time of surgery using sentinel lymph node biopsy or axillary lymph node dissection. The number of lymph nodal involvement is also significant. Involvement of 1-3 lymph nodes carry better prognosis than 4-9 and more than 9 lymph nodes involvement. Size of the tumour has long been recognized as a prognostic factor and as predictor of axillary node status, with larger tumours being associated with a bad prognosis and an increased incidence of nodal metastasis. This study is conducted in Department of General Surgery, SVRRGGH, Sri Venkateswara Medical College, Tirupati for a period of more than one and half year after getting approval from Institutional Ethical Committee on March 2021. A prospective study of 50 patients who fulfilled Inclusion Criteria is taken into consideration to know how prognostic factors like tumor size & grade, axillary lymphnode involvement are influencing the prognosis and management of breast carcinoma. Patients who took part in the study were from 28-68 years of age. Majority of people were in the age group of 46-55 years (38%). Increasing age, involvement of axillary lymph nodes, tumors with larger size and higher grade, and lymphovascular invasions are all associated with worse prognosis Keywords: Estrogen Receptor, Progesterone Receptor, Locally Advanced Breast Carcinoma
{"title":"A Study on Prognostic Factors in Management of Breast Carcinoma in A Tertiary Care Hospital","authors":"Sivaramakrishna Valluru, C Srikanth Reddy, Shanmukha Srinivasulu Udayagiri, Sada Surya Vidavaluru","doi":"10.18579/jopcr/v22.2.23.42","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.42","url":null,"abstract":"Breast cancer is the most common malignant tumor and leading cause of death in women worldwide. It accounts for 15% of all cancer deaths According to World Health Organisation (WHO), approximately 70% of breast malignancies occur in women with unknown risk factorsThe prognostic factor can be defined as a measurable variable which correlates with natural history of the disease. The most significant factor which influences prognosis in breast cancer is axillary lymph node involvement, which is usually assessed at time of surgery using sentinel lymph node biopsy or axillary lymph node dissection. The number of lymph nodal involvement is also significant. Involvement of 1-3 lymph nodes carry better prognosis than 4-9 and more than 9 lymph nodes involvement. Size of the tumour has long been recognized as a prognostic factor and as predictor of axillary node status, with larger tumours being associated with a bad prognosis and an increased incidence of nodal metastasis. This study is conducted in Department of General Surgery, SVRRGGH, Sri Venkateswara Medical College, Tirupati for a period of more than one and half year after getting approval from Institutional Ethical Committee on March 2021. A prospective study of 50 patients who fulfilled Inclusion Criteria is taken into consideration to know how prognostic factors like tumor size & grade, axillary lymphnode involvement are influencing the prognosis and management of breast carcinoma. Patients who took part in the study were from 28-68 years of age. Majority of people were in the age group of 46-55 years (38%). Increasing age, involvement of axillary lymph nodes, tumors with larger size and higher grade, and lymphovascular invasions are all associated with worse prognosis Keywords: Estrogen Receptor, Progesterone Receptor, Locally Advanced Breast Carcinoma","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18579/jopcr/v22.1.ms230208
O. Adetunji, Elizabeth Alabi, M. Adeyemo
The aim of the study was to characterize native and thermally silicified blends of sweet potato and sorghum starch granules using their physicochemical and rheological properties. Sweet potato ( Ipomea batatas L., Family: Convolvulaceae ) and sorghum ( Sorghum bicolor , Family: Poaceae ) starches (PS and SS respectively) were extracted and silicified by dissolving 25%w/w silicon dioxide in ultra-pure water containing 75%w/w starch with continuous stirring at 42 (cid:6) 0.5 o C for 4 mins and subsequently oven-dried (45 (cid:6) 0.5 o C) to form sPS and sSS respectively. Physical blends of sPS and sSS granules in ratios 1:1, 1:2 and 2:1 were made and compared with granule blends of PS and SS at similar ratios. Angle of repose, density measurements, Carr’s index, Hausner’s ratio, morphology, pH, swelling capacity and FTIR spectroscopy were
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Pub Date : 2023-05-15DOI: 10.18579/jopcr/v22.1.22.ms230301
B. M. Ishaq, C. H. Kumar
Writing a research proposal for funding is a crucial skill for researchers seeking to secure financial support for their projects. A well-drafted proposal can convince funding agencies about scientific, commercial and social impact of the research project and also researcher's competence and skill. However, crafting a persuasive proposal is always challenging, and many researchers struggle with where to start and how to structure the proposal. This manuscript aims to provide a comprehensive guide for writing a research project proposal for funding. It discusses the key elements involved in the research process and outlines the essential components of a persuasive research proposal. It provides a helpful guidance on how to hone in on a research question, pinpoint a knowledge gap, and define specific goals for the study. It also explores different research methodologies and provides guidance on how to select the most appropriate approach for a given research project. It further provides tips on how to structure the proposal effectively, including the use of clear and concise language, and the inclusion of relevant and compelling supporting evidence. In conclusion, it will serve as a thorough and practical resource for anyone looking to secure financial backing for their next research endeavor. Our endeavor is to provide invaluable tool for scientists who are applying for grants or seeking funding for their research endeavors. Keywords: Research proposal, Well-crafted proposal, Manuscript, Writing, Comprehensive guide
{"title":"Crafting a Convincing Research Proposal: A Guide to Writing Successful Funding Applications","authors":"B. M. Ishaq, C. H. Kumar","doi":"10.18579/jopcr/v22.1.22.ms230301","DOIUrl":"https://doi.org/10.18579/jopcr/v22.1.22.ms230301","url":null,"abstract":"Writing a research proposal for funding is a crucial skill for researchers seeking to secure financial support for their projects. A well-drafted proposal can convince funding agencies about scientific, commercial and social impact of the research project and also researcher's competence and skill. However, crafting a persuasive proposal is always challenging, and many researchers struggle with where to start and how to structure the proposal. This manuscript aims to provide a comprehensive guide for writing a research project proposal for funding. It discusses the key elements involved in the research process and outlines the essential components of a persuasive research proposal. It provides a helpful guidance on how to hone in on a research question, pinpoint a knowledge gap, and define specific goals for the study. It also explores different research methodologies and provides guidance on how to select the most appropriate approach for a given research project. It further provides tips on how to structure the proposal effectively, including the use of clear and concise language, and the inclusion of relevant and compelling supporting evidence. In conclusion, it will serve as a thorough and practical resource for anyone looking to secure financial backing for their next research endeavor. Our endeavor is to provide invaluable tool for scientists who are applying for grants or seeking funding for their research endeavors. Keywords: Research proposal, Well-crafted proposal, Manuscript, Writing, Comprehensive guide","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42782153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18579/jopcr/v22.1.22.31
P. Sidat, Sakshi Modh, Niyati Chavda, V. Chauhan, Geera Kankura, Aneri Dindoliwala
Neem (Azadirachta indica) belongs to the Meliaceae family. Neem is well-known around the world for its medicinal and nutritional properties. Various parts of the plant like fruits, leaves, flowers, twigs, gum, seed, oil, bark, and root are known to have medicinal properties and are scientifically established for the various properties. Since ancient times, plant’s parts have been utilized for their medicinal value. The plant contains a high amount of catalase (CAT), peroxidase (POD), polyphenol oxidase (PPO) and ascorbate peroxidase (APX) enzyme, and many other phytoconstituents such as isoprenoid-containing protomeliacins, limonoids, azadirone and Csecomeliacins such as azadirachtin, nimbin, and salanin. The non-isoprenoids include sulphurous compounds, polyphenolics like flavonoids and their glycosides, dihydrochalcone, coumarin and tannins, proteins (amino acids) and carbohydrates (polysaccharides), as well as aliphatic compounds. Due to such type of versatile phytoconstituents, the plants show lots of pharmacological applications. In this review article, we summarized the information regarding the various pharmacological activities of neem plants. All information presented in this review article regarding the beneficial application of Neem (Azadirachta indica) has been acquired by imminent various electronic databases including Scopus, Google scholar, Science Direct, Web of Science, and PubMed. The Neem plant, including leaves, bark, latex, seed, and their active constituents, plays a significant part in the management of progressive illness. The neem plant contains active ingredients were accountable for the basketful therapeutic function such as anticancer, anti-inflammatory, antidiabetic, antispasmodic, antifungal, antioxidant, antimicrobial, antimalarial, antifertility, and also helps in proper digestion, hair growth, skin related problems and relief in menstrual pain and many more. The main findings showed that neem has strong medicinal properties and is also useful in cosmetic applications. There is no evidence of adverse effects of neem in literature. Only the people who are allergic to it can have side effects otherwise it is stomach friendly in all conditions due to which it can be applicable for treatment of various health related disorders. Keywords: Neem (Azadirachta indica), Phytochemical constituents, Therapeutic application
印楝属楝科。印度楝树因其药用和营养价值而闻名于世。这种植物的不同部分，如果实、叶子、花、细枝、树胶、种子、油、树皮和根，都具有药用价值，并已被科学地证实具有各种价值。自古以来，植物的部分就被用于其药用价值。该植物含有大量的过氧化氢酶(CAT)、过氧化物酶(POD)、多酚氧化酶(PPO)和抗坏血酸过氧化物酶(APX)酶，以及许多其他植物成分，如含异戊二烯类原酸、柠檬酮、氮扎二酮和印楝素、宁宾和salanin等Csecomeliacins。非异戊二烯类化合物包括含硫化合物、类黄酮及其糖苷等多酚类物质、二氢查尔酮、香豆素和单宁、蛋白质(氨基酸)和碳水化合物(多糖)，以及脂肪族化合物。由于这种类型的多用途植物成分，植物显示出许多药理应用。本文就印楝植物的各种药理活性进行综述。这篇综述文章中关于印楝(Azadirachta indica)有益应用的所有信息都已通过各种电子数据库获得，包括Scopus，谷歌scholar, Science Direct, Web of Science和PubMed。印楝树，包括叶子、树皮、乳胶、种子和它们的活性成分，在治疗进行性疾病中起着重要的作用。楝树植物含有有效成分，具有抗癌、抗炎、抗糖尿病、抗痉挛、抗真菌、抗氧化、抗菌、抗疟疾、抗生育等多种治疗功能，还有助于适当消化、头发生长、皮肤相关问题和缓解月经疼痛等。主要研究结果表明，印度楝树具有很强的药用特性，在化妆品中也很有用。文献中没有证据表明印楝有不良反应。只有对它过敏的人才会有副作用，否则它在所有情况下都是胃友好的，因此它可以适用于治疗各种健康相关疾病。关键词:印楝，植物化学成分，治疗应用
{"title":"Neem (Azadirachta indica): A Panacea of all Diseases","authors":"P. Sidat, Sakshi Modh, Niyati Chavda, V. Chauhan, Geera Kankura, Aneri Dindoliwala","doi":"10.18579/jopcr/v22.1.22.31","DOIUrl":"https://doi.org/10.18579/jopcr/v22.1.22.31","url":null,"abstract":"Neem (Azadirachta indica) belongs to the Meliaceae family. Neem is well-known around the world for its medicinal and nutritional properties. Various parts of the plant like fruits, leaves, flowers, twigs, gum, seed, oil, bark, and root are known to have medicinal properties and are scientifically established for the various properties. Since ancient times, plant’s parts have been utilized for their medicinal value. The plant contains a high amount of catalase (CAT), peroxidase (POD), polyphenol oxidase (PPO) and ascorbate peroxidase (APX) enzyme, and many other phytoconstituents such as isoprenoid-containing protomeliacins, limonoids, azadirone and Csecomeliacins such as azadirachtin, nimbin, and salanin. The non-isoprenoids include sulphurous compounds, polyphenolics like flavonoids and their glycosides, dihydrochalcone, coumarin and tannins, proteins (amino acids) and carbohydrates (polysaccharides), as well as aliphatic compounds. Due to such type of versatile phytoconstituents, the plants show lots of pharmacological applications. In this review article, we summarized the information regarding the various pharmacological activities of neem plants. All information presented in this review article regarding the beneficial application of Neem (Azadirachta indica) has been acquired by imminent various electronic databases including Scopus, Google scholar, Science Direct, Web of Science, and PubMed. The Neem plant, including leaves, bark, latex, seed, and their active constituents, plays a significant part in the management of progressive illness. The neem plant contains active ingredients were accountable for the basketful therapeutic function such as anticancer, anti-inflammatory, antidiabetic, antispasmodic, antifungal, antioxidant, antimicrobial, antimalarial, antifertility, and also helps in proper digestion, hair growth, skin related problems and relief in menstrual pain and many more. The main findings showed that neem has strong medicinal properties and is also useful in cosmetic applications. There is no evidence of adverse effects of neem in literature. Only the people who are allergic to it can have side effects otherwise it is stomach friendly in all conditions due to which it can be applicable for treatment of various health related disorders. Keywords: Neem (Azadirachta indica), Phytochemical constituents, Therapeutic application","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46459614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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