Clinical efficacy and safety of Gandouling plus low-dose D-penicillamine for treatment of Wilson's disease with neurological symptoms

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional Chinese Medicine Pub Date : 2018-02-01 DOI:10.1016/j.jtcm.2018.02.006
Zhang Jing, Li Liangyong, Chen Huaizhen, Yang Wenming
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引用次数: 5

Abstract

OBJECTIVE

To investigate the effect and safety of Gandouling plus low-dose D-penicillamine for treating patients with Wilson's disease (WD) who have neurological symptoms.

METHODS

WD patients with neurological symptoms were divided into two groups: a treatment group (n = 53) and a control group (n = 50). The treatment group received anti-copper therapy with a combination of Gandouling and low-dose D-penicillamine (10 mg/kg), whereas the control group was with conventional dose D-penicillamine (20 mg/kg) monotherapy. The clinical efficacies, adverse reactions, and results of the various hematological and biochemical investigations were recorded and analyzed statistically.

RESULTS

Overall, 98.11% of the WD patients treated with the combined therapy experienced alleviation of their neurological condition (paralleled by a significantly improved Global Assessment Scale score or remained stable). Their white blood cell and platelet counts stabilized, and their liver function was improved or remained stable. The combined therapy also obviously promoted improved 24-h urinary copper excretion. Only 15.09% of the WD patients with the combined therapy experienced adverse reactions, including neurological deterioration in one case (1.89%) and hepatic worsening in one case (1.89%), which was less frequent than that in the control group given conventional-dose D-penicillamine monotherapy.

CONCLUSION

Treating WD patients with neurological symptoms using Gandouling plus low-dose D-penicillamine is effective and safe.

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甘道夫灵联合小剂量d -青霉胺治疗伴有神经系统症状的肝豆状核变性的临床疗效和安全性
目的探讨甘多灵联合小剂量d -青霉胺治疗伴有神经系统症状的威尔逊氏病(WD)的疗效和安全性。方法将伴有神经系统症状的swd患者分为治疗组(n = 53)和对照组(n = 50)。治疗组采用甘豆灵联合低剂量d -青霉胺(10 mg/kg)抗铜治疗,对照组采用常规剂量d -青霉胺(20 mg/kg)单药治疗。对两组患者的临床疗效、不良反应及各项血液学、生化检查结果进行统计分析。结果总体而言,接受联合治疗的WD患者中,98.11%的患者神经系统状况得到缓解(全球评估量表评分显著提高或保持稳定)。他们的白细胞和血小板计数稳定,肝功能改善或保持稳定。联合用药可明显改善24小时尿铜排泄。联合治疗的WD患者不良反应发生率仅为15.09%,其中神经系统恶化1例(1.89%),肝脏恶化1例(1.89%),低于常规剂量d -青霉胺单药治疗的对照组。结论甘多灵联合小剂量d -青霉胺治疗伴有神经系统症状的WD患者安全有效。
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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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