Combination of primary CNS lymphoma and mycobacteriosis of the brain in the background of HIV infection

M. A. Savchenko, N. Voinov, D. Sitovskaya, O. M. Vorobieva, Y. Zabrodskaya, R. Grozov, A. Panteleev
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Abstract

Aim of the study. To present a clinical observation of a combined brain tissue lesion in a patient with HIV infection, which emphasizes the complexity of the differential diagnosis process when making a final diagnosis, the need for interdisciplinary interaction of trained specialists.Materials and methods. The description of clinical observation, results of instrumental diagnostic methods is performed. The data of histological and immunohistochemical examination of the biopsy of the patient’s brain tissue are presented.Results and conclusion. Damage to the central nervous system in patients with HIV infection is characterized by a wide range of etiological factors. Diagnosis, in this case, is a complex task and requires a comprehensive examination of the patient, including performing computed tomography, magnetic resonance imaging of the brain, as well as cultural and molecular genetic methods of studying cerebrospinal fluid. Pathognomonic clinical manifestations and neuroradiological syndromes do not exist, and several pathogens can be released simultaneously in the biological fluids of the patient. In addition to determining the etiology of the infectious process, it is necessary to exclude a brain tumor lesion with possible biopsy, histological and immunohistochemical verification of the neoplasm.
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HIV感染背景下原发性中枢神经系统淋巴瘤合并脑分枝杆菌病
研究目的。对一名艾滋病毒感染患者的合并脑组织损伤进行临床观察,强调在做出最终诊断时鉴别诊断过程的复杂性,需要训练有素的专家进行跨学科互动。材料和方法。对临床观察、仪器诊断方法的结果进行了描述。提供了患者脑组织活检的组织学和免疫组织化学检查数据。结果和结论。HIV感染患者的中枢神经系统损伤具有广泛的病因特征。在这种情况下,诊断是一项复杂的任务,需要对患者进行全面检查,包括进行计算机断层扫描、大脑磁共振成像,以及研究脑脊液的文化和分子遗传学方法。不存在病理性临床表现和神经放射学综合征,患者的体液中可以同时释放几种病原体。除了确定感染过程的病因外,还需要排除脑肿瘤病变,并对肿瘤进行可能的活检、组织学和免疫组织化学验证。
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来源期刊
HIV Infection and Immunosuppressive Disorders
HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
37
期刊介绍: In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.
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