Assessment of Molecular Mechanism of Saffron Anti-Stress Property

IF 1.1 Q4 PHARMACOLOGY & PHARMACY Research Journal of Pharmacognosy Pub Date : 2021-04-14 DOI:10.22127/RJP.2021.266106.1660

B. Arjmand, Mahmood Khodadoost, Mohhamadreza Razzaghi, M. Tavirani, A. Ahmadzadeh, Sina Rezaei Tavirani

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引用次数: 1

Abstract

Background and objectives: There are several documents about protective properties of saffron against stress conditions which refer to the effect of saffron on gene expression pattern of the treated samples.The aim of the present study was determination of the main regulated proteins by saffron extract. Methods: Twenty differentially expressed proteins from a published research were investigated via network analysis and assessed to determine the crucial regulated individuals by Cetoscape software. The network was analyzed by network analyzer application of Cytoscape software and the central nodes were identified. Results: Twenty queried proteins were included in a network with 9005 nodes and 11446 edges. Analysis of the network revealed that VCP, SOD1, GRP78 (HSPA5), GRP75 (HSPA9), PRDX1, PHB, COMT, and ATP5H are the central proteins which are regulated by saffron extract. Conclusion: Based on the regulated proteins, regulation of mithoconderia and endoplasmic reticulum was identified as the main target of saffron in stress management.

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藏红花抗胁迫特性的分子机制研究

背景与目的:目前已有多篇文献报道藏红花对应激条件下基因表达模式的影响。本研究的目的是测定藏红花提取物的主要调节蛋白。方法:通过网络分析对已发表的20个差异表达蛋白进行研究，并通过Cetoscape软件评估确定关键调控个体。应用Cytoscape软件进行网络分析，确定了网络的中心节点。结果:在9005个节点和11446条边的网络中包含了20个被查询的蛋白质。网络分析表明，VCP、SOD1、GRP78 (HSPA5)、GRP75 (HSPA9)、PRDX1、PHB、COMT和ATP5H是受藏红花提取物调控的中心蛋白。结论:从调控蛋白的角度出发，确定藏红花调控密孔细胞和内质网是其调控应激的主要靶点。

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