Medication adherence in HIV-positive pregnant women on antiretroviral therapy attending antenatal clinics in Ado metropolis, south-west Nigeria: A multicentre study

IF 0.4 Q4 OBSTETRICS & GYNECOLOGY South African Journal of Obstetrics and Gynaecology Pub Date : 2020-12-15 DOI:10.7196/SAJOG.1611
O. P. Aduloju, T. Aduloju, I. Ade-Ojo, A. Akintayo
{"title":"Medication adherence in HIV-positive pregnant women on antiretroviral therapy attending antenatal clinics in Ado metropolis, south-west Nigeria: A multicentre study","authors":"O. P. Aduloju, T. Aduloju, I. Ade-Ojo, A. Akintayo","doi":"10.7196/SAJOG.1611","DOIUrl":null,"url":null,"abstract":"Background. Adherence to antiretroviral therapy (ART) and optimal viral suppression are crucial to the prevention of mother-to-child transmission (PMTCT) of HIV/AIDS.  Objective. To determine adherence to ART and associated factors in Ado-Ekiti, Nigeria.  Methods. A cross-sectional multicentre study was conducted among 170 HIV-positive pregnant women attending antenatal clinics of Ekiti State University Teaching Hospital and the Comprehensive Health Centre in Ado-Ekiti. Data collected using a semi-structured questionnaire were analysed with SPSS. Descriptive statistics, univariate and logistic regression were performed to determine factors associated with good adherence.  Results. Using the pill count method and the Morisky Medication Adherence Scale-8 (MMAS-8), the prevalence of good adherence was 73.5% and 75.3%, respectively. Women with higher education were three times more likely to practise good adherence than those with little or no formal education (adjusted odds ratio (aOR)=3.03; 95% confidence interval (CI) 1.23 - 5.79; p =0.043) and those employed were four times more likely to practise good adherence (aOR=4.13; 95% CI 1.83 - 8.15; p =0.02). Also, partner disclosure, treatment support and use of ARVs for prevention of mother-to-child transmission (PMTCT) were indications of women three times more likely to practise good adherence ((aOR=2.53; 95% CI 0.99 - 5.80; p =0.035); (aOR=2.15; 95% CI 0.77 - 4.15; p =0.014) and (aOR=3.15; 95% CI 0.93 - 6.21; p =0.035)). Forgetfulness, busy schedule and stigmatisation were reasons given for non-adherence.  Conclusions. The majority of the women had good adherence. However, counselling on adherence and partner disclosure should be sustained to ensure full benefits of PMTCT.","PeriodicalId":49579,"journal":{"name":"South African Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Journal of Obstetrics and Gynaecology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7196/SAJOG.1611","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Background. Adherence to antiretroviral therapy (ART) and optimal viral suppression are crucial to the prevention of mother-to-child transmission (PMTCT) of HIV/AIDS.  Objective. To determine adherence to ART and associated factors in Ado-Ekiti, Nigeria.  Methods. A cross-sectional multicentre study was conducted among 170 HIV-positive pregnant women attending antenatal clinics of Ekiti State University Teaching Hospital and the Comprehensive Health Centre in Ado-Ekiti. Data collected using a semi-structured questionnaire were analysed with SPSS. Descriptive statistics, univariate and logistic regression were performed to determine factors associated with good adherence.  Results. Using the pill count method and the Morisky Medication Adherence Scale-8 (MMAS-8), the prevalence of good adherence was 73.5% and 75.3%, respectively. Women with higher education were three times more likely to practise good adherence than those with little or no formal education (adjusted odds ratio (aOR)=3.03; 95% confidence interval (CI) 1.23 - 5.79; p =0.043) and those employed were four times more likely to practise good adherence (aOR=4.13; 95% CI 1.83 - 8.15; p =0.02). Also, partner disclosure, treatment support and use of ARVs for prevention of mother-to-child transmission (PMTCT) were indications of women three times more likely to practise good adherence ((aOR=2.53; 95% CI 0.99 - 5.80; p =0.035); (aOR=2.15; 95% CI 0.77 - 4.15; p =0.014) and (aOR=3.15; 95% CI 0.93 - 6.21; p =0.035)). Forgetfulness, busy schedule and stigmatisation were reasons given for non-adherence.  Conclusions. The majority of the women had good adherence. However, counselling on adherence and partner disclosure should be sustained to ensure full benefits of PMTCT.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
尼日利亚西南部阿多大都市产前诊所接受抗逆转录病毒治疗的HIV阳性孕妇的药物依从性:一项多中心研究
背景。坚持抗逆转录病毒治疗(ART)和最佳病毒抑制对预防艾滋病毒/艾滋病母婴传播(PMTCT)至关重要。目标。确定尼日利亚Ado-Ekiti地区抗逆转录病毒治疗依从性及相关因素。方法。对在埃基蒂州立大学教学医院产前诊所和阿多埃基蒂综合保健中心就诊的170名艾滋病毒阳性孕妇进行了一项横断面多中心研究。采用半结构化问卷收集的数据用SPSS进行分析。采用描述性统计、单变量和逻辑回归来确定与良好依从性相关的因素。结果。采用药片计数法和Morisky用药依从性量表-8 (MMAS-8),良好依从率分别为73.5%和75.3%。受过高等教育的妇女比受过很少或没有受过正规教育的妇女更有可能保持良好的依从性(调整优势比(aOR)=3.03;95%置信区间(CI) 1.23 ~ 5.79;p =0.043),而那些被雇佣的人更有可能保持良好的依从性(aOR=4.13;95% ci 1.83 - 8.15;p = 0.02)。此外,伴侣信息披露、治疗支持和使用抗逆转录病毒药物预防母婴传播(PMTCT)是妇女良好依从性的三倍(aOR=2.53;95% ci 0.99 - 5.80;p = 0.035);(aOR = 2.15;95% ci 0.77 - 4.15;p =0.014), (aOR=3.15;95% ci 0.93 - 6.21;p = 0.035)。健忘、繁忙的日程和耻辱是不遵守规定的原因。结论。大多数妇女都有良好的依从性。然而,应该持续进行依从性和伴侣披露方面的咨询,以确保预防母婴传播的充分益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
South African Journal of Obstetrics and Gynaecology
South African Journal of Obstetrics and Gynaecology Medicine-Obstetrics and Gynecology
CiteScore
0.40
自引率
0.00%
发文量
5
审稿时长
15 weeks
期刊介绍: The SAJOG is a tri-annual, general specialist obstetrics and gynaecology journal that publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. The journal carries original research articles, editorials, clinical practice, personal opinion, South Africa health-related news, obituaries and general correspondence.
期刊最新文献
Does adding coenzyme Q10 to dehydroepiandrosterone sulphate positively impact fertility outcomes in young, poor responder infertile women undergoing antagonist protocol for IVF/ICSI cycles? Prevalence and severity of depression and anxiety in infertile female patients attending an academic hospital in central South Africa Is medicine a process of scientific rigour? How to care for fetuses with prenatally diagnosed severe abnormalities Prevalence of and sociodemographic factors associated with antenatal depression among women in Limpopo Province, South Africa
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1