{"title":"Grafting Drugs to Functionalized Single-wall Carbon Nanotubes as a Potential Method for Drug Delivery","authors":"Maryam Heidarian, A. Khazaei, J. Saien","doi":"10.22036/PCR.2020.232018.1775","DOIUrl":null,"url":null,"abstract":"The mesalazine and fluvoxamine drugs were grafted to single-walled carbon nanotubes (SWCNTs) for the aim of precise drug delivery. First, carboxylic groups in SWCNT were converted to corresponding acyl chlorides. Next, to attain the formation of amide bonds, acyl chloride-SWCNTs were mixed with chemotherapeutic agents, having NH2 and NH functional groups. Then, the covalently grafted drugs to SWCNT were characterized by UV- visible, IR spectroscopy, and transmission electron microscopy (TEM) methods. Finally, the prepared organic compounds were used for releasing drugs at pH: 1.3, which is corresponding to clinical aspects of the human body, and were examined for the potential of drug delivery in patients. Accordingly, the in-vitro kinetic as well as the mechanism of the released drugs were investigated.","PeriodicalId":20084,"journal":{"name":"Physical Chemistry Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physical Chemistry Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22036/PCR.2020.232018.1775","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 2
Abstract
The mesalazine and fluvoxamine drugs were grafted to single-walled carbon nanotubes (SWCNTs) for the aim of precise drug delivery. First, carboxylic groups in SWCNT were converted to corresponding acyl chlorides. Next, to attain the formation of amide bonds, acyl chloride-SWCNTs were mixed with chemotherapeutic agents, having NH2 and NH functional groups. Then, the covalently grafted drugs to SWCNT were characterized by UV- visible, IR spectroscopy, and transmission electron microscopy (TEM) methods. Finally, the prepared organic compounds were used for releasing drugs at pH: 1.3, which is corresponding to clinical aspects of the human body, and were examined for the potential of drug delivery in patients. Accordingly, the in-vitro kinetic as well as the mechanism of the released drugs were investigated.
期刊介绍：
The motivation for this new journal is the tremendous increasing of useful articles in the field of Physical Chemistry and the related subjects in recent years, and the need of communication between Physical Chemists, Physicists and Biophysicists. We attempt to establish this fruitful communication and quick publication. High quality original papers in English dealing with experimental, theoretical and applied research related to physics and chemistry are welcomed. This journal accepts your report for publication as a regular article, review, and Letter. Review articles discussing specific areas of physical chemistry of current chemical or physical importance are also published. Subjects of Interest: Thermodynamics, Statistical Mechanics, Statistical Thermodynamics, Molecular Spectroscopy, Quantum Chemistry, Computational Chemistry, Physical Chemistry of Life Sciences, Surface Chemistry, Catalysis, Physical Chemistry of Electrochemistry, Kinetics, Nanochemistry and Nanophysics, Liquid Crystals, Ionic Liquid, Photochemistry, Experimental article of Physical chemistry. Mathematical Chemistry.
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