Effects of renal Na-Cl co-transporter on calcium homeostasis and bone metabolism

Bingbin Zhao, Lei Zhang
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Abstract

Osteoporosis is a global public health problem. The kidney, especially the Na-Cl co-transporter (NCC) located in the renal distal tubular cells, which is an important transporter for urinary calcium regulation, plays an important role in calcium homeostasis and bone metabolism. This review summarized recent researches on effects and mechanisms of NCC on calcium and bone metabolism. Key words: Na-Cl co-transporter; Calcium homeostasis; Bone metabolism
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肾Na-Cl共转运体对钙稳态和骨代谢的影响
骨质疏松症是一个全球性的公共卫生问题。肾脏尤其是位于肾远端小管细胞的Na-Cl共转运体(NCC)是尿钙调节的重要转运体,在钙稳态和骨代谢中起着重要作用。本文就NCC对钙和骨代谢的影响及其机制的研究进展作一综述。关键词:Na-Cl共转运体;钙稳态;骨代谢
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来源期刊
中华临床营养杂志
中华临床营养杂志 Nursing-Nutrition and Dietetics
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2282
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