Anti-hypertensive effect of Siddha formulation Imbural Vadagam against Human angiotensin converting enzyme using In-Silico model

Abstract

Background: Siddha Medicine is emerging as the treatment of choice for various diseases. Hypertension is one among the comorbidities which plays a major role leading to stroke, cardiovascular diseases and renal failure.  Objective: To perform the In Silico computational studies of phytocomponents of Imbural vadagam and to evaluate its anti-hypertensive potential. Methods: Auto dock program was used for the molecular docking studies against Angiotensin Converting Enzyme(ACE). Results: Asperulosidic acid, 6α-Hydroxygeniposide, Piperic acid, Piperine, Apigenin, Orientin and Vitexin that exist in the siddha drug Imbural vadagam exhibit remarkable binding against the target Angiotensin converting enzyme. Conclusion: It can be that these phytocomponents exhibit remarkable antihypertensive activity.