Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3687
Dhanashri Joil, Swagata Dilip Tavhare
Background: Breast cancer is one of the leading causes for cancer mortality. The conventional treatments are being rprted for many side effects which affects quality of life of a patient. Novel therapeutic and preventative strategies from the medicinal herbs are needed to reduce suffering, disease free survival, and mortality from breast cancer. Withania somnifera L. Dunal (Indian winter cherry or Ashwagandha) from the Solanaceae family is an appealing medicinal plant widely investigated for its breast cancer potential. Ayurveda treaties explained various formulations using root of Ashwagandha. Modern science explained uses of root and leaf in extract forms. Withaferin A is a promising anticancer withanolides. This review is based on in-vitro researches of Withaferin A on breast cancer cell lines like MCF-7 cells, MDA-MB-231, SUM159, MDA-MB-468, SUM149,SUM159, 231MFP supported by its mechanism, in-vivo studies and clinical records. Material and methods: This review is based on various preclinical researches related to breast cancer. Moreover, this review represents the effect of Withaferin A on cancer cell. Various articles including studies and description of Ashwagandha were reviewed using databases namely Google Scholar, PubMed, Web of Science, Scopus. Result:Withaferin A significantly arrests the growth of many breast cancer cell in vivo and in vitro. Conclusion: Ashwagandha is a commonly available, cost effective natural medicine,possess anti-cancer potential. It can serves a add on treatment strategy for breast cancer management, chemoprevention, tumor suppression.
背景:乳腺癌是导致癌症死亡的主要原因之一。据报道，传统的治疗方法有许多副作用，影响病人的生活质量。需要从草药中获得新的治疗和预防策略，以减少乳腺癌的痛苦、无病生存和死亡率。来自茄科的Withania somnifera L. Dunal(印度冬季樱桃或Ashwagandha)是一种有吸引力的药用植物，因其乳腺癌的潜力而被广泛研究。阿育吠陀条约解释了使用阿什瓦甘达根的各种配方。现代科学以提取物的形式解释了根和叶的用途。Withaferin A是一种很有前途的抗癌药物。本文综述了Withaferin A对MCF-7细胞、MDA-MB-231、SUM159、MDA-MB-468、SUM149、SUM159、231MFP等乳腺癌细胞系的体外研究，并结合其作用机制、体内研究和临床记录进行了综述。材料和方法:本综述基于各种与乳腺癌相关的临床前研究。此外，本文综述了Withaferin A对癌细胞的作用。使用Google Scholar、PubMed、Web of Science、Scopus等数据库对包括Ashwagandha研究和描述在内的各种文章进行了审查。结果:Withaferin A在体内和体外均能显著抑制多种乳腺癌细胞的生长。结论:印度人参是一种常见的、经济有效的天然药物，具有抗癌潜力。它可以作为乳腺癌管理、化学预防、肿瘤抑制的补充治疗策略。
{"title":"Role of Withaferin A in the management of breast cancer: A comprehensive review","authors":"Dhanashri Joil, Swagata Dilip Tavhare","doi":"10.47552/ijam.v14i3.3687","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3687","url":null,"abstract":"Background: Breast cancer is one of the leading causes for cancer mortality. The conventional treatments are being rprted for many side effects which affects quality of life of a patient. Novel therapeutic and preventative strategies from the medicinal herbs are needed to reduce suffering, disease free survival, and mortality from breast cancer. Withania somnifera L. Dunal (Indian winter cherry or Ashwagandha) from the Solanaceae family is an appealing medicinal plant widely investigated for its breast cancer potential. Ayurveda treaties explained various formulations using root of Ashwagandha. Modern science explained uses of root and leaf in extract forms. Withaferin A is a promising anticancer withanolides. This review is based on in-vitro researches of Withaferin A on breast cancer cell lines like MCF-7 cells, MDA-MB-231, SUM159, MDA-MB-468, SUM149,SUM159, 231MFP supported by its mechanism, in-vivo studies and clinical records. Material and methods: This review is based on various preclinical researches related to breast cancer. Moreover, this review represents the effect of Withaferin A on cancer cell. Various articles including studies and description of Ashwagandha were reviewed using databases namely Google Scholar, PubMed, Web of Science, Scopus. Result:Withaferin A significantly arrests the growth of many breast cancer cell in vivo and in vitro. Conclusion: Ashwagandha is a commonly available, cost effective natural medicine,possess anti-cancer potential. It can serves a add on treatment strategy for breast cancer management, chemoprevention, tumor suppression.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3756
Sucheta Pilankar, Arati P Dubewar, Sonali C Chitali, Nilima S Dharkar
The Pottali rasayana Kalpana is one among the four types of rejuvenation formulations (Chaturvidh rasayana Kalpana) of mercury (Parad). They are known for its specific method of preparation, unique end product, optimum potency, smaller dosage and larger therapeutic applicability. Praval garbha pottali is a herbo-mineral complex formulation. Gandhak paka method was selected for preparation as it is the most commonly used procedure. It also is a best method to enhance the efficiency of the drugs and keep them in a concise form. The description of Pottali rasayana Kalpana is found in numerous Rasagranthas (Classical books of Rasa shastra); however, very less research work is carried out on them, and minimal research is carried out on Praval garbha pottali. Pottali rasayana Kalpana are not well-versed in current ayurvedic practice due to the lack of research study. XRD, FTIR, and EDS mapping is carried out on the prepared pravalgarbha pottali.
{"title":"Analytical study and preparation of praval garbha pottali","authors":"Sucheta Pilankar, Arati P Dubewar, Sonali C Chitali, Nilima S Dharkar","doi":"10.47552/ijam.v14i3.3756","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3756","url":null,"abstract":"The Pottali rasayana Kalpana is one among the four types of rejuvenation formulations (Chaturvidh rasayana Kalpana) of mercury (Parad). They are known for its specific method of preparation, unique end product, optimum potency, smaller dosage and larger therapeutic applicability. Praval garbha pottali is a herbo-mineral complex formulation. Gandhak paka method was selected for preparation as it is the most commonly used procedure. It also is a best method to enhance the efficiency of the drugs and keep them in a concise form. The description of Pottali rasayana Kalpana is found in numerous Rasagranthas (Classical books of Rasa shastra); however, very less research work is carried out on them, and minimal research is carried out on Praval garbha pottali. Pottali rasayana Kalpana are not well-versed in current ayurvedic practice due to the lack of research study. XRD, FTIR, and EDS mapping is carried out on the prepared pravalgarbha pottali.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3814
Nishant Patel, Nisha Munishwar, Prakash Kumbar
Apabahuka (Frozen shoulder-FS) is a disease that affects the shoulder joint. Frozen shoulder is also known as adhesive capsulitis, it is characterized by pain and stiffness in the shoulder joint and upper arm muscles with restricted mobility. Apabahuka is a Vataj vyadhi associated with Kapha dosha. The prevalence of FS varies from 11.4% to 19% in India. FS is commonly found between 40 to 70 years and most common in females. Various modalities are available to treat FS such as nonsteroidal anti-inflammatory drugs, corticosteroids, physiotherapy, ultrasound therapy, arthroscopic surgery, or a combination of treatments done still no satisfactory results are found. In the present case report, a 50-year-old female patient consulted with the chief complaints of pain, stiffness, restricted mobility of shoulder joint and pain while lifting weight along with disturbed sleep. Patient was diagnosed as a Abhighatjanya Apabahuka (Traumatic FS). The patient was assessed on the basis of Visual Analogue Scale (VAS), Stiffness Gradation, Tenderness Gradation and range of movements using Goniometer. Patient was treated with Panchakarma therapies and internal medication. The outcome of Ayurvedic management of FS was encouraging to reduce subjective and objective parameters.
{"title":"Management of Abhighatjanya Apabahuka (Traumatic Frozen shoulder) by Ayurveda: A Case study","authors":"Nishant Patel, Nisha Munishwar, Prakash Kumbar","doi":"10.47552/ijam.v14i3.3814","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3814","url":null,"abstract":"Apabahuka (Frozen shoulder-FS) is a disease that affects the shoulder joint. Frozen shoulder is also known as adhesive capsulitis, it is characterized by pain and stiffness in the shoulder joint and upper arm muscles with restricted mobility. Apabahuka is a Vataj vyadhi associated with Kapha dosha. The prevalence of FS varies from 11.4% to 19% in India. FS is commonly found between 40 to 70 years and most common in females. Various modalities are available to treat FS such as nonsteroidal anti-inflammatory drugs, corticosteroids, physiotherapy, ultrasound therapy, arthroscopic surgery, or a combination of treatments done still no satisfactory results are found. In the present case report, a 50-year-old female patient consulted with the chief complaints of pain, stiffness, restricted mobility of shoulder joint and pain while lifting weight along with disturbed sleep. Patient was diagnosed as a Abhighatjanya Apabahuka (Traumatic FS). The patient was assessed on the basis of Visual Analogue Scale (VAS), Stiffness Gradation, Tenderness Gradation and range of movements using Goniometer. Patient was treated with Panchakarma therapies and internal medication. The outcome of Ayurvedic management of FS was encouraging to reduce subjective and objective parameters.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Ayurveda depicts a disease named ‘Karshya’ which goes hand in hand with the clinical entity ‘Under-nutrition’ in contemporary science. Aim & Objectives: The present study aimed to compare the efficacy of ‘Pathadi churna’ and Protein Powder as oral administration in preschool children suffering from Under-nutrition. Methodology- The trial was a randomized parallel group carried out in 30 children aged 3 to 6 years presenting with the clinical features of under-nutrition who were divided into two groups equally. In Pathadi churna (group A-trial) and protein powder (control, group B), Pathadi churna and protein powder respectively was given in dosage according to age as per Young’s formula for 60 days. Results were analyzed according to frequency %, PEM (protein energy malnutrition) gradation shift, changes in assessment parameters, and the level of significance were noted by using Wilcoxon signed rank test and the Student’s paired t-test. Results- Significant results were noted in Daurabalya (~Fatigue) in both the groups whereas the Pathadi churna group showed significant results in the Agnimandya (~Lack of appetite & poor digestion), weight, weight for height, BMI, PEM gradation, and the values of hemoglobin, serum proteins & calcium. On comparing both groups, statistically significant differences were seen in Pathadi churna than Protein powder. Conclusion- Significant results were seen in Daurbalya in both the groups but on comparison more significant effects were noted for all subjective and objective criteria in the Pathadi churna group. No ADR was reported in the study. Further large sample studies with standard control would render better evidence in results with justification.
{"title":"A comparative study on the effectiveness of Pathadi churna and Protein powder in Karshya (Undernutrition) among preschool children","authors":"Renu B Rathi, Monali Kurhadkar, Bharat J Rathi, Sandesh Khobragade, Sumod Khedekar","doi":"10.47552/ijam.v14i3.3612","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3612","url":null,"abstract":"Introduction: Ayurveda depicts a disease named ‘Karshya’ which goes hand in hand with the clinical entity ‘Under-nutrition’ in contemporary science. Aim & Objectives: The present study aimed to compare the efficacy of ‘Pathadi churna’ and Protein Powder as oral administration in preschool children suffering from Under-nutrition. Methodology- The trial was a randomized parallel group carried out in 30 children aged 3 to 6 years presenting with the clinical features of under-nutrition who were divided into two groups equally. In Pathadi churna (group A-trial) and protein powder (control, group B), Pathadi churna and protein powder respectively was given in dosage according to age as per Young’s formula for 60 days. Results were analyzed according to frequency %, PEM (protein energy malnutrition) gradation shift, changes in assessment parameters, and the level of significance were noted by using Wilcoxon signed rank test and the Student’s paired t-test. Results- Significant results were noted in Daurabalya (~Fatigue) in both the groups whereas the Pathadi churna group showed significant results in the Agnimandya (~Lack of appetite & poor digestion), weight, weight for height, BMI, PEM gradation, and the values of hemoglobin, serum proteins & calcium. On comparing both groups, statistically significant differences were seen in Pathadi churna than Protein powder. Conclusion- Significant results were seen in Daurbalya in both the groups but on comparison more significant effects were noted for all subjective and objective criteria in the Pathadi churna group. No ADR was reported in the study. Further large sample studies with standard control would render better evidence in results with justification.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3646
Pavithra Jaivarshaa, Devyani Dasar, Akshay Kumar
Background- Exploitation of analgesics is becoming an advent scenario in the current practice of both medical and surgical cases. Adopting a less complicated and a wholesome beneficial modality for post operative analgesia is the need of the hour. In this case series, focus has been placed on yashti ghrit matra basti as the intervention for pain and wound management of post-operative cases of chronic fissure in ano associated with internal haemorrhoids. Objective- The current study was aimed at post operative analgesia and wound management with yashti ghrit matra basti in ano-rectal cases. Material & Methods-The method adopted here was Lord’s anal dilatation followed by excision of sentinel tags or ligation haemorrhoidectomy according to the case presentation, followed by yashti ghrit mastra basti as primary ayurvedic intervention for post operative analgesia and wound healing. Results -It is found that the planned treatment gave a positive response as post operative analgesia and also played an adjuvant role in wound healing. Conclusion-This case series provides the successful pain and wound management of post-operative ano-rectal cases with a promising ayurvedic intervention.
{"title":"Efficacy of Yashtimadhu ghrit matra basti in post-operative management of Ano-rectal Cases – A case Series","authors":"Pavithra Jaivarshaa, Devyani Dasar, Akshay Kumar","doi":"10.47552/ijam.v14i3.3646","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3646","url":null,"abstract":"Background- Exploitation of analgesics is becoming an advent scenario in the current practice of both medical and surgical cases. Adopting a less complicated and a wholesome beneficial modality for post operative analgesia is the need of the hour. In this case series, focus has been placed on yashti ghrit matra basti as the intervention for pain and wound management of post-operative cases of chronic fissure in ano associated with internal haemorrhoids. Objective- The current study was aimed at post operative analgesia and wound management with yashti ghrit matra basti in ano-rectal cases. Material & Methods-The method adopted here was Lord’s anal dilatation followed by excision of sentinel tags or ligation haemorrhoidectomy according to the case presentation, followed by yashti ghrit mastra basti as primary ayurvedic intervention for post operative analgesia and wound healing. Results -It is found that the planned treatment gave a positive response as post operative analgesia and also played an adjuvant role in wound healing. Conclusion-This case series provides the successful pain and wound management of post-operative ano-rectal cases with a promising ayurvedic intervention.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3959
Mallika Gogoi, Jharna Chakravorty
Assam one of the North Eastern states of India is gifted with diverse natural resources and inhabited by varied ethnic communities. Dhemaji district of Assam is also not exceptional in this regard. A survey was conducted on zootherapeutics among the traditional healers of Dhemaji district through personal interview from 2016 January to 2017 January in fifteen non tribal inhabited villages among 75 respondents of the age group 50-70years. It was documented that the ethnic people of Dhemaji used a total of 26 species of non conventional food items for their therapeutic value against various ailments including itching, burning, asthma, paralysis, weakness etc. These species include varieties of vertebrate and invertebrate species such as arthropods, molluscs, amphibians, aves, reptiles, pisces and mammals depending on their seasonal availability. The highest no of animal species used for the traditional therapeutics is mammals (29%) followed by pisces (19%), arthropoda and reptiles(15%), aves (13%) and the least are amphibia and mollusca (each comprises only 4% species). The study reveals that the ethnic people of Dhemaji are rich in traditional therapeutics and proper documentation and scientific analysis may lead to new drug discovery and conservation of these valuable faunal species.
{"title":"Ethnozoological survey of Non conventional food items and their therapeutic use by the traditional healers of Dhemaji district of Assam, North-East India","authors":"Mallika Gogoi, Jharna Chakravorty","doi":"10.47552/ijam.v14i3.3959","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3959","url":null,"abstract":"Assam one of the North Eastern states of India is gifted with diverse natural resources and inhabited by varied ethnic communities. Dhemaji district of Assam is also not exceptional in this regard. A survey was conducted on zootherapeutics among the traditional healers of Dhemaji district through personal interview from 2016 January to 2017 January in fifteen non tribal inhabited villages among 75 respondents of the age group 50-70years. It was documented that the ethnic people of Dhemaji used a total of 26 species of non conventional food items for their therapeutic value against various ailments including itching, burning, asthma, paralysis, weakness etc. These species include varieties of vertebrate and invertebrate species such as arthropods, molluscs, amphibians, aves, reptiles, pisces and mammals depending on their seasonal availability. The highest no of animal species used for the traditional therapeutics is mammals (29%) followed by pisces (19%), arthropoda and reptiles(15%), aves (13%) and the least are amphibia and mollusca (each comprises only 4% species). The study reveals that the ethnic people of Dhemaji are rich in traditional therapeutics and proper documentation and scientific analysis may lead to new drug discovery and conservation of these valuable faunal species.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3744
Abhilasha C Lagad, Vishwas E Gogate, Almas Y Khan, Pooja S Kombe, Pallavi N Mane, None Abhijit Shekhar
Prameha (Diabetes mellitus) is an age long disease known from vedic period and now it is a leading lifestyle disorder. Diabetes mellitus is a group of metabolic syndromes of fat, protein and carbohydrate which is due to absolute or relative deficiency of insulin. The prevalence of diabetes in India has risen from 7.1% in 2009 to 8.9% in 2019.1 The estimates in 2019 showed that 77 million individuals had diabetes in India, which is expected to rise to over 134 million by 2045.2 In India, it is also 3rd leading cause of death (After heart disease and cancer). The number is projected to be twice by 2030. Type 2 diabetes makes up about 85-90% of all cases. Increase in the overall diabetes prevalence rates largely reflect an increase in risk factors for type 2, notably greater longevity and being overweight or obese. Hence preventive measures are essential and an ideal therapy is still obscure. It remains one of the baffling enigmas for clinical research. This is a randomized single blind standard controlled clinical trial conducted on 66 patients of Prameha (Type II DM & who are on antidiabetic treatment) to rule out Add on effect of Triphaladaruadi kwath of either gender between age group of 40-60 years and grouped into Group A & Group B. 33 patients in group A were on Antidiabetic drug (Metformin 500mg OD/BD and 33 patients in Group B are on same antidiabetic drug (Metformin 500mg OD/BD) with additional Triphaladaruadi kwath (Decoction) for 3 months. Results obtained in subjective and objective parameters were analyzed for the statistical significance by adapting paired ‘t’ test in the groups, Two-way ANOVA test between the groups, and Wilcoxon rank sum test. The study revealed that Group B was found to be more effective in bringing symptomatic relief and improving biochemical markers in the patients of Prameha.
{"title":"Clinical study of add on effect of Triphaladaruadi Kwatha (Vangsenokta) along with antidiabetic drug in management of Prameha (Non-Insulin Dependent Diabetes mellitus- NIDDM)","authors":"Abhilasha C Lagad, Vishwas E Gogate, Almas Y Khan, Pooja S Kombe, Pallavi N Mane, None Abhijit Shekhar","doi":"10.47552/ijam.v14i3.3744","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3744","url":null,"abstract":"Prameha (Diabetes mellitus) is an age long disease known from vedic period and now it is a leading lifestyle disorder. Diabetes mellitus is a group of metabolic syndromes of fat, protein and carbohydrate which is due to absolute or relative deficiency of insulin. The prevalence of diabetes in India has risen from 7.1% in 2009 to 8.9% in 2019.1 The estimates in 2019 showed that 77 million individuals had diabetes in India, which is expected to rise to over 134 million by 2045.2 In India, it is also 3rd leading cause of death (After heart disease and cancer). The number is projected to be twice by 2030. Type 2 diabetes makes up about 85-90% of all cases. Increase in the overall diabetes prevalence rates largely reflect an increase in risk factors for type 2, notably greater longevity and being overweight or obese. Hence preventive measures are essential and an ideal therapy is still obscure. It remains one of the baffling enigmas for clinical research. This is a randomized single blind standard controlled clinical trial conducted on 66 patients of Prameha (Type II DM & who are on antidiabetic treatment) to rule out Add on effect of Triphaladaruadi kwath of either gender between age group of 40-60 years and grouped into Group A & Group B. 33 patients in group A were on Antidiabetic drug (Metformin 500mg OD/BD and 33 patients in Group B are on same antidiabetic drug (Metformin 500mg OD/BD) with additional Triphaladaruadi kwath (Decoction) for 3 months. Results obtained in subjective and objective parameters were analyzed for the statistical significance by adapting paired ‘t’ test in the groups, Two-way ANOVA test between the groups, and Wilcoxon rank sum test. The study revealed that Group B was found to be more effective in bringing symptomatic relief and improving biochemical markers in the patients of Prameha.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3391
Gaurav Sinha, Kalpana Patni
Ardhavabhedaka is described as one of the eleven types of Shiroroga (headache disorders) in all Ayurvedic classical texts. It is a disease in which there is acute pain in half of the head, laterals of the neck, temporal region, ear and eyes. Based on the similarity in etiology, pathology, symptoms and treatment principles Ardhavabhedaka can be very well connected with migraine. As per the International Headache Society (IHS), Migraine accounts for 16% of all primary headaches. As per WHO, Migraine prevalence and incidence of the attack suggest that migraine attacks around 3000 persons per million populations every day globally. Aim of Study: To compare the effect of Dashmula saindhavaa Sarpi Nasya and Oral in the Management of Ardhavabhedaka wsr to Migraine. Material and Methods: Total of 68 patients of age group 16 to 60 years of either sex were enrolled based on headache as the chief complaint. After screening via a Pre-diagnostic questionnaire (IHS), 24 patients were excluded and 44 patients recruited were randomly divided into two groups, group A received Dashmula saindhavaa Sarpi nasya, 6 drops in each nostril for 7 days, repeated after intervals of 1 week (four cycles) and Group B received Dashmula saindhava Sarpi orally 12 grams/day in two divided doses for 2 months. The assessment was done based on 4 point grading score of Clinical symptoms of Ardhavabhedaka (Migraine). Result: Overall effect of therapy shows that in Group A 05.00% had the complete cure, 50.00% of patients had marked improvement and 40.00% had moderate improvement whereas, in Group B, 05.88% had the complete cure, 35.29% of patients had marked improvement and 35.29% had moderate improvement. Both groups showed highly significant results (p = >0.001) in severity, duration, and frequency and various parameters of Ardhavabhedaka with more percentage improvement in Group A i.e., with Nasya therapy. Conclusion: Clinical assessment of Dashmula saindhava Sarpi nasya and as oral therapy on different parameters of Ardhavabhedaka showed that both are effective and safe.
{"title":"Comparative Evaluation of Dashamula saindhavaa Sarpi as Nasya (nasal administration) versus Oral administration in the Management of Ardhavabhedaka (~Migraine): A Randomized Parallel Group Clinical Study","authors":"Gaurav Sinha, Kalpana Patni","doi":"10.47552/ijam.v14i3.3391","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3391","url":null,"abstract":"Ardhavabhedaka is described as one of the eleven types of Shiroroga (headache disorders) in all Ayurvedic classical texts. It is a disease in which there is acute pain in half of the head, laterals of the neck, temporal region, ear and eyes. Based on the similarity in etiology, pathology, symptoms and treatment principles Ardhavabhedaka can be very well connected with migraine. As per the International Headache Society (IHS), Migraine accounts for 16% of all primary headaches. As per WHO, Migraine prevalence and incidence of the attack suggest that migraine attacks around 3000 persons per million populations every day globally. Aim of Study: To compare the effect of Dashmula saindhavaa Sarpi Nasya and Oral in the Management of Ardhavabhedaka wsr to Migraine. Material and Methods: Total of 68 patients of age group 16 to 60 years of either sex were enrolled based on headache as the chief complaint. After screening via a Pre-diagnostic questionnaire (IHS), 24 patients were excluded and 44 patients recruited were randomly divided into two groups, group A received Dashmula saindhavaa Sarpi nasya, 6 drops in each nostril for 7 days, repeated after intervals of 1 week (four cycles) and Group B received Dashmula saindhava Sarpi orally 12 grams/day in two divided doses for 2 months. The assessment was done based on 4 point grading score of Clinical symptoms of Ardhavabhedaka (Migraine). Result: Overall effect of therapy shows that in Group A 05.00% had the complete cure, 50.00% of patients had marked improvement and 40.00% had moderate improvement whereas, in Group B, 05.88% had the complete cure, 35.29% of patients had marked improvement and 35.29% had moderate improvement. Both groups showed highly significant results (p = >0.001) in severity, duration, and frequency and various parameters of Ardhavabhedaka with more percentage improvement in Group A i.e., with Nasya therapy. Conclusion: Clinical assessment of Dashmula saindhava Sarpi nasya and as oral therapy on different parameters of Ardhavabhedaka showed that both are effective and safe.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3808
Mrudula Wadekar, Adsul V B
Backgroud: Shauktika Bhasma is a traditional ayurvedic medicine which is an excellent remedy for a number of stomach disorders, hyper acidity and ulcers. It is prepared from mother pearl by subjecting the powder of mother pearl to traditional ayurvedic processes. To get a worldwide recognition to such supreme ancient medicine, it is necessary to reinvestigate it on the basis of modern analytical techniques.In the present work a comparative study of some commercial samples of Shauktika bhasma is undertaken to understand the current status of this bhasma and to explore its acid neutralization capacity using back titration method. Materials and Methods: Samples from renowned pharmacies are collected and subjected to chemical and structural investigations using analytical techniques like XRD, IR and UV. Back titration method is applied to find acid neutralizing capacity of these bhasma samples. Conclusion:The study reveals that Shauktika bhasma is chemically calcite form of calcium carbonate. Antacid activity of the samples is reported for these samples using simple titration method which is useful to estimate number of moles neutralized for a quick comparison. The antacid activity of the samples is found to be inversely proportional to the crystallite size of the bhasma.
{"title":"A comparative Study of Structural Properties and Antacid activity of some commercial samples of Shauktika bhasma","authors":"Mrudula Wadekar, Adsul V B","doi":"10.47552/ijam.v14i3.3808","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3808","url":null,"abstract":"Backgroud: Shauktika Bhasma is a traditional ayurvedic medicine which is an excellent remedy for a number of stomach disorders, hyper acidity and ulcers. It is prepared from mother pearl by subjecting the powder of mother pearl to traditional ayurvedic processes. To get a worldwide recognition to such supreme ancient medicine, it is necessary to reinvestigate it on the basis of modern analytical techniques.In the present work a comparative study of some commercial samples of Shauktika bhasma is undertaken to understand the current status of this bhasma and to explore its acid neutralization capacity using back titration method. Materials and Methods: Samples from renowned pharmacies are collected and subjected to chemical and structural investigations using analytical techniques like XRD, IR and UV. Back titration method is applied to find acid neutralizing capacity of these bhasma samples. Conclusion:The study reveals that Shauktika bhasma is chemically calcite form of calcium carbonate. Antacid activity of the samples is reported for these samples using simple titration method which is useful to estimate number of moles neutralized for a quick comparison. The antacid activity of the samples is found to be inversely proportional to the crystallite size of the bhasma.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rasashastra is a Pharmacotherapeutics of Mercurial, Metallic, and Mineral preparations Abhrasindoora (AS) is a unique Herbo-Metallic-Mineral Compound, which is mainly indicated in respiratory diseases. Method: AS contains Dhanyabhraka (Bio-purified Black Mica Powder), Shodhita Parada (Bio-purified Mercury), and Shodhita Gandhaka (Bio-purified Sulphur) in equal proportion. These mixtures were subjected to trituration in Kharal till Kajjali formation (ABS-72 hrs) followed by impregnation of latex of Arka (Calotropis procera linn) (QS) (16 hrs) and Vatashunga (Ficus benghalensis linn) (QS) (15 hrs). Then Batch-A & Batch-B were prepared separately in Valuka Yantra and Electric Muffle furnace by maintaining mild (150 0C-250 0C), (150 0C - 300 0C) moderate (250 0C -400 0C), (300 0C -450 0C) and intense temperature (400 0C - 550 0C), (450 0C -650 0C) respectively. Observation: Batch A AS was prepared in 37 hours and the total yield of the product obtained was 54 grams. Batch B AS was prepared in 21 hours and the total yield of the product obtained was 25 grams. Jet black colour Kajjali of AS turned to dark red which was sublimated at the neck of Kachkupi. Conclusion: The yield of Batch A was more than Batch B but it took more time. Hence, the preparation of Kupipakva Rasayana in a sand bath should be done repeatedly to conclude it is a more economic and convenient process.
{"title":"A Comparative Pharmaceutical Study of Abhrasindoora by Traditional and Contemporary Method","authors":"Rakesh Bramhankar, Abhaya Kumar Mishra, Nisha Munishwar, Himangshu Baruah, Snigdha Mandal","doi":"10.47552/ijam.v14i3.3802","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3802","url":null,"abstract":"Background: Rasashastra is a Pharmacotherapeutics of Mercurial, Metallic, and Mineral preparations Abhrasindoora (AS) is a unique Herbo-Metallic-Mineral Compound, which is mainly indicated in respiratory diseases. Method: AS contains Dhanyabhraka (Bio-purified Black Mica Powder), Shodhita Parada (Bio-purified Mercury), and Shodhita Gandhaka (Bio-purified Sulphur) in equal proportion. These mixtures were subjected to trituration in Kharal till Kajjali formation (ABS-72 hrs) followed by impregnation of latex of Arka (Calotropis procera linn) (QS) (16 hrs) and Vatashunga (Ficus benghalensis linn) (QS) (15 hrs). Then Batch-A & Batch-B were prepared separately in Valuka Yantra and Electric Muffle furnace by maintaining mild (150 0C-250 0C), (150 0C - 300 0C) moderate (250 0C -400 0C), (300 0C -450 0C) and intense temperature (400 0C - 550 0C), (450 0C -650 0C) respectively. Observation: Batch A AS was prepared in 37 hours and the total yield of the product obtained was 54 grams. Batch B AS was prepared in 21 hours and the total yield of the product obtained was 25 grams. Jet black colour Kajjali of AS turned to dark red which was sublimated at the neck of Kachkupi. Conclusion: The yield of Batch A was more than Batch B but it took more time. Hence, the preparation of Kupipakva Rasayana in a sand bath should be done repeatedly to conclude it is a more economic and convenient process.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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