Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4544
Rohan Mohandas, Kiran B Ganiger, Rajat Thakur, S. Shetty, Manasa M
Birth of a child is said to be no less than a miracle. The conception per say happens through the contributions by both the male and the female counter parts and is equally influenced by them. It is important to evaluate both the partners for a healthy conception. Ayurveda explains four important factors which are required for the manifestation of the garbha or for the conception to take place; they are rutu, kshetra, ambu and beeja. Alteration in any of the four factors might cause a hindrance for conception. Hence, evaluating these factors in both male and female counter parts as applicable is of utmost importance prior to conception. A male patient aged 34 years consulted us for pre conception care with a trying period of 6 months and marital life of 6 months. He was advised to undergo semen analysis which revealed presence of a large number of leukocytes in the semen sample and hence was diagnosed as pyospermic/leukocytospermic, which can be understood as pooti puya shukra dushti in Ayurveda, which can further be classified as a pittaja shukra dushti in a broader sense. He was treated with shodhana procedures of virechana and nasya to correct the beeja dushti followed by vajikarana chikitsa to enhance the health of beeja. Post treatment pus cells in semen reduced completely. Patient’s wife was able to conceive with a healthy intrauterine foetus with an anomaly scan showing no structural abnormality of the foetus.
{"title":"Pre-conception care rendered to a male factor of Pyospermia/ Leukocytospermia leading to conception and Healthy pregnancy of the female counterpart – A case report","authors":"Rohan Mohandas, Kiran B Ganiger, Rajat Thakur, S. Shetty, Manasa M","doi":"10.47552/ijam.v15i2.4544","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4544","url":null,"abstract":"Birth of a child is said to be no less than a miracle. The conception per say happens through the contributions by both the male and the female counter parts and is equally influenced by them. It is important to evaluate both the partners for a healthy conception. Ayurveda explains four important factors which are required for the manifestation of the garbha or for the conception to take place; they are rutu, kshetra, ambu and beeja. Alteration in any of the four factors might cause a hindrance for conception. Hence, evaluating these factors in both male and female counter parts as applicable is of utmost importance prior to conception. A male patient aged 34 years consulted us for pre conception care with a trying period of 6 months and marital life of 6 months. He was advised to undergo semen analysis which revealed presence of a large number of leukocytes in the semen sample and hence was diagnosed as pyospermic/leukocytospermic, which can be understood as pooti puya shukra dushti in Ayurveda, which can further be classified as a pittaja shukra dushti in a broader sense. He was treated with shodhana procedures of virechana and nasya to correct the beeja dushti followed by vajikarana chikitsa to enhance the health of beeja. Post treatment pus cells in semen reduced completely. Patient’s wife was able to conceive with a healthy intrauterine foetus with an anomaly scan showing no structural abnormality of the foetus. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141659374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4417
Neha M Saunshimath, Shrutika S Karoshi, Kishore Bhat, Vijay Kumbhar
Background: Cancer is still a complicated and difficult condition with serious consequences for the general population. Currently, it poses a major risk to the global health. There are numerous risk factors associated with cancer. They include tobacco, obesity, excessive consumption of packed foods, lack of physical activity, alcohol consumption, etc. Continued prevention, research & early detection are required to improve outcomes for cancer patients. Anticancer medications have been associated with cardiotoxicity, compromising individuals' heart function. Early detection of cardiotoxicity is essential for avoiding irreparable heart damage. Cardio-oncology has arisen as a distinct area of study and therapeutic practice in recent years. Several aspects of drug-induced cardiotoxicity remain unknown. Such toxicities are considered as garavisha in Ayurveda. They can be treated by using Agada principles. Insect bites can lead to cardiac symptoms, according to both ancient and modern science. Acharya Vagbhata has mentioned hrudpeeda as one of the lakshana of Vataja Vrischika damsha. Dashanga Agada (DA) is the formulation mentioned in context of Keeta visha. As it is the formulation of choice in insect bites exhibiting cardiac symptoms, it is studied in present research to reduce the cardiotoxicity induced by doxorubicin (Dox). The study was carried out on H9C2 mice cardiomyoblasts. Materials and Methods: Hydroalcoholic extract of Ayurvedic formulation Dashanga agada was prepared. H9C2 mice cardiomyoblasts were used to study trial drug Dashanga Agada on cardiotoxicity induced by a chemotherapy drug named Doxorubicin. MTT assay, DAPI nuclear staining, DCFH-DA assay for intracellular ROS generation & SOD assay were the four parameters studied on H9C2 cell line. 4 groups were taken for the study. Dashanga agada was studied at different concentrations & different time intervals on the above mentioned parameters. Results: IC50 values of DA & Dox for 24hrs were calculated to be 357.15 & 5.48 µg/ml respectively. Dashanga agada was effective in increasing cell viability, improving the nuclear morphology & antioxidant activity when compared to Doxorubicin treated group. Conclusion: Dashanga Agada has cardioprotective effect. Within parallel & pre-treatment groups, parallel treatment gave better results.
{"title":"Cardioprotective activity of Dashanga Agada in Doxorubicin induced Cardiotoxicity in Mice Cardiomyoblasts (H9c2)","authors":"Neha M Saunshimath, Shrutika S Karoshi, Kishore Bhat, Vijay Kumbhar","doi":"10.47552/ijam.v15i2.4417","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4417","url":null,"abstract":"Background: Cancer is still a complicated and difficult condition with serious consequences for the general population. Currently, it poses a major risk to the global health. There are numerous risk factors associated with cancer. They include tobacco, obesity, excessive consumption of packed foods, lack of physical activity, alcohol consumption, etc. Continued prevention, research & early detection are required to improve outcomes for cancer patients. Anticancer medications have been associated with cardiotoxicity, compromising individuals' heart function. Early detection of cardiotoxicity is essential for avoiding irreparable heart damage. Cardio-oncology has arisen as a distinct area of study and therapeutic practice in recent years. Several aspects of drug-induced cardiotoxicity remain unknown. Such toxicities are considered as garavisha in Ayurveda. They can be treated by using Agada principles. Insect bites can lead to cardiac symptoms, according to both ancient and modern science. Acharya Vagbhata has mentioned hrudpeeda as one of the lakshana of Vataja Vrischika damsha. Dashanga Agada (DA) is the formulation mentioned in context of Keeta visha. As it is the formulation of choice in insect bites exhibiting cardiac symptoms, it is studied in present research to reduce the cardiotoxicity induced by doxorubicin (Dox). The study was carried out on H9C2 mice cardiomyoblasts. Materials and Methods: Hydroalcoholic extract of Ayurvedic formulation Dashanga agada was prepared. H9C2 mice cardiomyoblasts were used to study trial drug Dashanga Agada on cardiotoxicity induced by a chemotherapy drug named Doxorubicin. MTT assay, DAPI nuclear staining, DCFH-DA assay for intracellular ROS generation & SOD assay were the four parameters studied on H9C2 cell line. 4 groups were taken for the study. Dashanga agada was studied at different concentrations & different time intervals on the above mentioned parameters. Results: IC50 values of DA & Dox for 24hrs were calculated to be 357.15 & 5.48 µg/ml respectively. Dashanga agada was effective in increasing cell viability, improving the nuclear morphology & antioxidant activity when compared to Doxorubicin treated group. Conclusion: Dashanga Agada has cardioprotective effect. Within parallel & pre-treatment groups, parallel treatment gave better results.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4421
Bhaskar K. Kurangi, Sunil S. Jalalpure, Mayuri Joshi, Umesh Patil
An attempt has been made to develop stability representing the reverse-phase High-Performance Liquid Chromatography (RP-HPLC) method for quantitative estimation of quercetin Nanostructure liquid crystalline dispersion. HPLC method was developed by C-18 column with the mobile phase comprising of 0.4% orthophosphoric acid [OPA]: Acetonitrile [ACN] (45:55, v/v), isocratically pumped with a rate of flow 1 mL/min and 255 nm detection wavelength. The method validation of HPLC parameters and degradation tests was analysed by International Conference on Harmonization (ICH) guidelines. The developed HPLC method was found to be specific, linear (r2>0.999) over the selected range of concentration 2-14μg/mL, precise, with the limit of detection (LOD) and limit of quantification (LOQ) as 0.021 and 0.064μg/mL respectively. The entrapment efficiency of quercetin for prepared Nanostructure Liquid Crystalline Dispersion (NLCD) was observed to be 94.55 %. The developed HPLC method was applied for the quantification of quercetin in NLCD. The quercetin peak was completely resolved without any disturbances from degrading products and additives. The developed HPLC method was found to be specific, sensitive, and adequate for the regular assay of marketed products, and NLCD nanoformulation containing quercetin.
{"title":"Development of stability indicating RP-HPLC method for Quercetin estimation in Nanostructure liquid crystalline dispersion","authors":"Bhaskar K. Kurangi, Sunil S. Jalalpure, Mayuri Joshi, Umesh Patil","doi":"10.47552/ijam.v15i2.4421","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4421","url":null,"abstract":"An attempt has been made to develop stability representing the reverse-phase High-Performance Liquid Chromatography (RP-HPLC) method for quantitative estimation of quercetin Nanostructure liquid crystalline dispersion. HPLC method was developed by C-18 column with the mobile phase comprising of 0.4% orthophosphoric acid [OPA]: Acetonitrile [ACN] (45:55, v/v), isocratically pumped with a rate of flow 1 mL/min and 255 nm detection wavelength. The method validation of HPLC parameters and degradation tests was analysed by International Conference on Harmonization (ICH) guidelines. The developed HPLC method was found to be specific, linear (r2>0.999) over the selected range of concentration 2-14μg/mL, precise, with the limit of detection (LOD) and limit of quantification (LOQ) as 0.021 and 0.064μg/mL respectively. The entrapment efficiency of quercetin for prepared Nanostructure Liquid Crystalline Dispersion (NLCD) was observed to be 94.55 %. The developed HPLC method was applied for the quantification of quercetin in NLCD. The quercetin peak was completely resolved without any disturbances from degrading products and additives. The developed HPLC method was found to be specific, sensitive, and adequate for the regular assay of marketed products, and NLCD nanoformulation containing quercetin.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4481
Ragesh C, Sudhikumar Kb
In Ayurveda Ruksha (Dry) Guna (Property)which is one among Gurvadi Guna(Biological qualities) cause dryness. The property of Ruksha Guna (Dry property) is increaseVata and normalizes Kapha and also decreases body Strength and normal colour of body. The main objective of study is to find out tool for assessing Ruksha guna in healthy individual. Based on theoretical reference, FGD and IDI conducted among experts 35 items are generated in two domains (Physical and Psychological). From this 29 items are selected for final administration on selected sample for validity and reliability assessment. Each item is scored using 4 point Likert scale -no, rarely, often, every time with scoring 0, 1, 2, 3 respectively. Subjective question assessed by interrogation and objective parameter dryness of body parts are also assessed by this scoring method. Total 100 samples are selected for final administration of sample. The tool with 29 items gave a Cronbach’s Alpha 0.745 (n=29) showing high construct validity and internal consistency. After the reliability and validity assessment 1 items deleted from the administered tool in the selected sample. Finally there are 28 items are included in the Ruksha Guna assessment tool.
{"title":"Development and validation of a tool to assess Rukshatha in healthy individual","authors":"Ragesh C, Sudhikumar Kb","doi":"10.47552/ijam.v15i2.4481","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4481","url":null,"abstract":"In Ayurveda Ruksha (Dry) Guna (Property)which is one among Gurvadi Guna(Biological qualities) cause dryness. The property of Ruksha Guna (Dry property) is increaseVata and normalizes Kapha and also decreases body Strength and normal colour of body. The main objective of study is to find out tool for assessing Ruksha guna in healthy individual. Based on theoretical reference, FGD and IDI conducted among experts 35 items are generated in two domains (Physical and Psychological). From this 29 items are selected for final administration on selected sample for validity and reliability assessment. Each item is scored using 4 point Likert scale -no, rarely, often, every time with scoring 0, 1, 2, 3 respectively. Subjective question assessed by interrogation and objective parameter dryness of body parts are also assessed by this scoring method. Total 100 samples are selected for final administration of sample. The tool with 29 items gave a Cronbach’s Alpha 0.745 (n=29) showing high construct validity and internal consistency. After the reliability and validity assessment 1 items deleted from the administered tool in the selected sample. Finally there are 28 items are included in the Ruksha Guna assessment tool. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4552
Sridhanya Venkataramanan, Rajeshwari V Kamat, Sanjay Ugare
Diabetes mellitus, a chronic non-communicable disorder, is on the rise in developing countries. In Ayurveda, a similar condition called Madhumeha is attributed to Dhatu kshaya (Emaciation) and Dosha avarana (occlusion of humoral factors). Rasayana therapy, involving herbal formulations like Nishamalaki, is recommended to strengthen the body's major structural components (dhatus), boost immunity, and promote longevity. Nishamalaki, a combination of Haridra (Curcuma longa Linn.) and Amalaki (Phyllantus emblica Linn.), exhibits antioxidant, anti-inflammatory, and lipid-reducing properties. It holds potential as a preventive measure to enhance the Quality of Life. The aim of this study was to validate the rejuvenation property of Nishamalaki in Diabetes mellitus using an insilico approach. Through tools such as SwissADME, SwissTargetPrediction, and Therapeutic Target Database (TTD), bioavailable components of Nishamalaki and Diabetes were analyzed, and a network was created using CytoScape. The results of the study identified two key compounds, Ellagic acid and Corilagin, which significantly modulate IGF1R and PTPN1, respectively, in Diabetes mellitus. These findings offer valuable insights into the potential therapeutic benefits of Nishamalaki in managing Diabetes mellitus and warrant further research and exploration in this area.
{"title":"Molecular Mechanism of Nishamalaki as Rasayana in Diabetes Mellitus","authors":"Sridhanya Venkataramanan, Rajeshwari V Kamat, Sanjay Ugare","doi":"10.47552/ijam.v15i2.4552","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4552","url":null,"abstract":"Diabetes mellitus, a chronic non-communicable disorder, is on the rise in developing countries. In Ayurveda, a similar condition called Madhumeha is attributed to Dhatu kshaya (Emaciation) and Dosha avarana (occlusion of humoral factors). Rasayana therapy, involving herbal formulations like Nishamalaki, is recommended to strengthen the body's major structural components (dhatus), boost immunity, and promote longevity. Nishamalaki, a combination of Haridra (Curcuma longa Linn.) and Amalaki (Phyllantus emblica Linn.), exhibits antioxidant, anti-inflammatory, and lipid-reducing properties. It holds potential as a preventive measure to enhance the Quality of Life. The aim of this study was to validate the rejuvenation property of Nishamalaki in Diabetes mellitus using an insilico approach. Through tools such as SwissADME, SwissTargetPrediction, and Therapeutic Target Database (TTD), bioavailable components of Nishamalaki and Diabetes were analyzed, and a network was created using CytoScape. The results of the study identified two key compounds, Ellagic acid and Corilagin, which significantly modulate IGF1R and PTPN1, respectively, in Diabetes mellitus. These findings offer valuable insights into the potential therapeutic benefits of Nishamalaki in managing Diabetes mellitus and warrant further research and exploration in this area. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.5014
Mounika Vallamchetty, Pavan Kumar Sangu
India is known as the Diabetic capital of the world due to the increasing Diabetic population. Diabetes is increasing day by day because of lifestyle changes. As per the WHO statistics around 2 million deaths occur each year because of diabetes. Hence there is a serious concern to find an effective and safe medicine for the treatment of diabetes. Many herbal drugs have been researched and found to be effective in controlling the diabetes. One of such herbs is Gymnema sylvestre (Retz.) R.Br. ex Sm. (GS). It is equated with Meshashrungi, mentioned in the Ayurvedic texts. Ajashrungi (Pergularia daemia (Forssk.) Chiov.) (PD) is also taken as a substitute for Meshashrungi. So, to find out the efficacy of both the drugs in the management of diabetes, the present work is taken up. It was a Prospective, Randomised, Single blind, Comparative Clinical Study. A total of 40 subjects were randomised into two groups with 20 subjects each. Group A were administered Meshashrungi patra vati and Group B were administered Ajashrungi patra vati for a period of 60 days with a follow up for every 15 days. Assessment was done based on changes seen in subjective and objective Parameters. Significant changes were observed in both the groups before and after the treatment, but when compared between the groups there was no significant difference. This indicates that both the drugs are equally efficacious in the management of diabetes mellitus. Hence, both the drugs can be used as substitutes for the management of diabetes mellitus.
{"title":"Effect of Meshashrungi Patra vati and Ajashrungi Patra vati in management of Type 2 Diabetes mellitus-A Randomised, Single blind, Clinical Study","authors":"Mounika Vallamchetty, Pavan Kumar Sangu","doi":"10.47552/ijam.v15i2.5014","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.5014","url":null,"abstract":"India is known as the Diabetic capital of the world due to the increasing Diabetic population. Diabetes is increasing day by day because of lifestyle changes. As per the WHO statistics around 2 million deaths occur each year because of diabetes. Hence there is a serious concern to find an effective and safe medicine for the treatment of diabetes. Many herbal drugs have been researched and found to be effective in controlling the diabetes. One of such herbs is Gymnema sylvestre (Retz.) R.Br. ex Sm. (GS). It is equated with Meshashrungi, mentioned in the Ayurvedic texts. Ajashrungi (Pergularia daemia (Forssk.) Chiov.) (PD) is also taken as a substitute for Meshashrungi. So, to find out the efficacy of both the drugs in the management of diabetes, the present work is taken up. It was a Prospective, Randomised, Single blind, Comparative Clinical Study. A total of 40 subjects were randomised into two groups with 20 subjects each. Group A were administered Meshashrungi patra vati and Group B were administered Ajashrungi patra vati for a period of 60 days with a follow up for every 15 days. Assessment was done based on changes seen in subjective and objective Parameters. Significant changes were observed in both the groups before and after the treatment, but when compared between the groups there was no significant difference. This indicates that both the drugs are equally efficacious in the management of diabetes mellitus. Hence, both the drugs can be used as substitutes for the management of diabetes mellitus. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4569
Bharath Christian CBS, N. Devi P., Ethel Shiny S, Jayalakshmi J
According to various classical Siddha literature, the varicose ulcer is compared with the symptoms of Naalavibatha punn / Naalasurrutu punn / Naalaviruvu punn. Treat varicose ulcers by prescribing Siddha internal medicines and external therapies. On August 5, 2022, a 48-year-old female patient attended the OPD of Santhigiri Siddha Medical College and Hospital, Trivandrum, with the following complaints: dilatation of veins, present in the right lower limb for 6 years; hyperpigmented lesion with itching and swelling above the medial malleolus of the right lower limb for 6 months; and an ulcer present above the medial malleolus for the last 3 months. She had a known case of varicose veins and had taken sclerotherapy three times but did not have satisfaction with the allopathic medication. The majority of the symptoms were significantly reduced in 60 days under the Siddha medications, such as a combination of Siddha preparation (Parangipattai Chooranam, Sangu Parpam, and Silasathu Parpam), Rasa gandhi mezhugu for internal, Padikara neer washing, wound dressing with Mathan thailam for external for 2 months, and attai vidal (leech application) done in 3 sittings in the gap of 10 days. No recurrence of any chronic varicose ulcer was observed during the 1 year of follow-up, and relevant preventive Siddha medication for Naalavibatha punn was given. The doctor advised the patient to do exercises that strengthen the legs and compression therapy. To summarize, the case report exhibited that Siddha leech therapy with both internal and external medications is very effective in the management of varicose ulcers.
{"title":"A Siddha Management of Attai vidal with internal and external medicines for Naalavibatha Punn (Varicose Ulcer): A Case Report","authors":"Bharath Christian CBS, N. Devi P., Ethel Shiny S, Jayalakshmi J","doi":"10.47552/ijam.v15i2.4569","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4569","url":null,"abstract":"According to various classical Siddha literature, the varicose ulcer is compared with the symptoms of Naalavibatha punn / Naalasurrutu punn / Naalaviruvu punn. Treat varicose ulcers by prescribing Siddha internal medicines and external therapies. On August 5, 2022, a 48-year-old female patient attended the OPD of Santhigiri Siddha Medical College and Hospital, Trivandrum, with the following complaints: dilatation of veins, present in the right lower limb for 6 years; hyperpigmented lesion with itching and swelling above the medial malleolus of the right lower limb for 6 months; and an ulcer present above the medial malleolus for the last 3 months. She had a known case of varicose veins and had taken sclerotherapy three times but did not have satisfaction with the allopathic medication. The majority of the symptoms were significantly reduced in 60 days under the Siddha medications, such as a combination of Siddha preparation (Parangipattai Chooranam, Sangu Parpam, and Silasathu Parpam), Rasa gandhi mezhugu for internal, Padikara neer washing, wound dressing with Mathan thailam for external for 2 months, and attai vidal (leech application) done in 3 sittings in the gap of 10 days. No recurrence of any chronic varicose ulcer was observed during the 1 year of follow-up, and relevant preventive Siddha medication for Naalavibatha punn was given. The doctor advised the patient to do exercises that strengthen the legs and compression therapy. To summarize, the case report exhibited that Siddha leech therapy with both internal and external medications is very effective in the management of varicose ulcers.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4581
Abha Lichade, Aayushi Deshmukh, Yashwant D. Nakhate, Pranali Kalambe
The goal of the drug discovery process is to search for new drug molecules which can bind to a specific target known to be involved in causing a disease. This study aims to identify potential inhibitors against the TGF-β-type-I receptor (PDB Id-1VJY) by developing ligands through molecular docking and ADMET-based virtual screening. The plant-based nature product database of Morus alba Linn is utilized for this purpose. The resultants hits, identified as actives were evaluated by molecular docking studies to get insight into their potential binding interaction with the target protein. 1-deoxynojirimycin (A1), Catechin (A2), Cyanidine-3-rutinoside (A3), Cyclomulberrin (A4), Kaempferol (A5), Kuwanon-G (A6), Morusin (A7), Mulberrin (A8), Mulberrofuran-G (A9), Quercetin-3-(6-malonylglucoside) (A10), Quercitrin (A11), Rutin (A12), were selected for the molecular docking.ADMET based virtual screening ligand/Compound (A1, A2, A4, A5, A7, A8, A9) passes the lipinski’s rule. Compound A4 (-10.7 kcal/mol), A5 (-10.4 kcal/mol) and A8 (-9.9 kcal/mol) had the highest binding affinity to the active site in TGF-β-type-I receptor. In conclusion, based on docking score and ADMET virtual screening, Cyclomulberrine (A4) (-10.7 kcal/mol) more affinity toward the TGF-β-type-I receptor that could be investigated further in the search for Hepatoprotective agent.
{"title":"Insilico Studies Unveiling the Hepatoprotective Potential of Morus alba Linn: Docking and ADMET Analysis","authors":"Abha Lichade, Aayushi Deshmukh, Yashwant D. Nakhate, Pranali Kalambe","doi":"10.47552/ijam.v15i2.4581","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4581","url":null,"abstract":"The goal of the drug discovery process is to search for new drug molecules which can bind to a specific target known to be involved in causing a disease. This study aims to identify potential inhibitors against the TGF-β-type-I receptor (PDB Id-1VJY) by developing ligands through molecular docking and ADMET-based virtual screening. The plant-based nature product database of Morus alba Linn is utilized for this purpose. The resultants hits, identified as actives were evaluated by molecular docking studies to get insight into their potential binding interaction with the target protein. 1-deoxynojirimycin (A1), Catechin (A2), Cyanidine-3-rutinoside (A3), Cyclomulberrin (A4), Kaempferol (A5), Kuwanon-G (A6), Morusin (A7), Mulberrin (A8), Mulberrofuran-G (A9), Quercetin-3-(6-malonylglucoside) (A10), Quercitrin (A11), Rutin (A12), were selected for the molecular docking.ADMET based virtual screening ligand/Compound (A1, A2, A4, A5, A7, A8, A9) passes the lipinski’s rule. Compound A4 (-10.7 kcal/mol), A5 (-10.4 kcal/mol) and A8 (-9.9 kcal/mol) had the highest binding affinity to the active site in TGF-β-type-I receptor. In conclusion, based on docking score and ADMET virtual screening, Cyclomulberrine (A4) (-10.7 kcal/mol) more affinity toward the TGF-β-type-I receptor that could be investigated further in the search for Hepatoprotective agent. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4385
Shubham Verma, P. Sawarkar, Mahesh Dodiya, Shweta Parwe
The World Health Organization (WHO) describes Obesity as a condition characterized by excessive deposition of body fat to the point where it adversely affects health. Body mass index (BMI) values within 25 and 29.9 kg/m2 and below 30 kg/m2 are two measures of the positive energy imbalance that leads to obesity. In 2000, World Health Organization identified Obesity as the most clearly evident yet most ignored public health problem worldwide. The World Health Organization ranks obesity as the second most dangerous disease in the world. The worldwide impact of Obesity is recorded to be 4 million obesity-related deaths and 40 million disability-adjusted life years among adults globally in 2015. Family history, frequent overeating patterns, and lack of physical activity are all significant risk factors. When treating Sthula (obese patients), Ruksha Udvartana is mentioned, which involves using a dry powder of herbs without oil is used. Therefore, for the current study, it was decided to choose the Rodhradigana Udvartana followed by Bhaspaswedana and Gomaya Mashi Udvartana followed by Bhaspaswedana as a comparative study. The purpose of the current study is to document and examine this process for statistical interpretation. Aim: Evaluation of Comparative efficacy of Rodhradi Gana Udvartana with Bhaspaswedana and Gomaya Mashi Udvartana with Bhaspawedana in the management of Sthoulya (obesity). Material and Methods: Data related to the disease as well as the drug was collected from Samhitas, other classical Ayurvedic literature, and various modern science books. Subjects visited to outdoor and indoor Panchakarma department and from the specialty camps were registered for the present study. Result: Significant improvement was observed in both groups and during comparison, more results were found in the Gomaya Mashi group (Group B). Conclusion: Udvartana with Gomaya Mashi followed by Bhaspasweda is more effective than Udvartana with Rodhradi Gana followed by Bhaspasweda in the management of Sthoulya (Overweight) and is an economical alternative without adverse effects.
世界卫生组织（WHO）将肥胖描述为一种以身体脂肪过度沉积并对健康产生不利影响为特征的疾病。体重指数（BMI）值在 25 至 29.9 kg/m2 之间和低于 30 kg/m2 是导致肥胖的正能量失衡的两个衡量标准。2000 年，世界卫生组织认定肥胖症是全球最明显但最被忽视的公共卫生问题。世界卫生组织将肥胖症列为全球第二大危险疾病。据记录，2015 年肥胖症对全球的影响是，全球有 400 万人死于肥胖症，4000 万人因肥胖症致残而调整寿命。家族遗传、经常暴饮暴食和缺乏体育锻炼都是重要的风险因素。在治疗 Sthula（肥胖患者）时，提到了 Ruksha Udvartana，即使用不含油的草药干粉。因此，在本次研究中，决定选择 Rodhradigana Udvartana 和 Gomaya Mashi Udvartana 进行比较研究，前者之后是 Bhaspaswedana，后者之后是 Bhaspaswedana。本研究的目的是记录和检查这一过程，以便进行统计解释。目的：评估 Rodhradi Gana Udvartana 与 Bhaspaswedana 和 Gomaya Mashi Udvartana 与 Bhaspawedana 在治疗 Sthoulya（肥胖症）方面的疗效比较。材料和方法：从 Samhitas、其他经典阿育吠陀文献和各种现代科学书籍中收集与疾病和药物相关的数据。在本研究中，登记了在室外和室内潘查卡玛部门以及专科营地就诊的受试者。研究结果两组受试者的病情均有明显改善，经比较发现，Gomaya Mashi 组（B 组）的疗效更好。结论在治疗 Sthoulya（超重）方面，使用 Gomaya Mashi 的 Udvartana 和 Bhaspasweda 比使用 Rodhradi Gana 的 Udvartana 和 Bhaspasweda 更有效，而且是一种经济实惠、无不良影响的替代疗法。
{"title":"Comparison of Gomaya Mashi and Rodhradi Gana Udvartana followed by Bhaspa Swedana in Sthoulya (Obesity)","authors":"Shubham Verma, P. Sawarkar, Mahesh Dodiya, Shweta Parwe","doi":"10.47552/ijam.v15i2.4385","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4385","url":null,"abstract":"The World Health Organization (WHO) describes Obesity as a condition characterized by excessive deposition of body fat to the point where it adversely affects health. Body mass index (BMI) values within 25 and 29.9 kg/m2 and below 30 kg/m2 are two measures of the positive energy imbalance that leads to obesity. In 2000, World Health Organization identified Obesity as the most clearly evident yet most ignored public health problem worldwide. The World Health Organization ranks obesity as the second most dangerous disease in the world. The worldwide impact of Obesity is recorded to be 4 million obesity-related deaths and 40 million disability-adjusted life years among adults globally in 2015. Family history, frequent overeating patterns, and lack of physical activity are all significant risk factors. When treating Sthula (obese patients), Ruksha Udvartana is mentioned, which involves using a dry powder of herbs without oil is used. Therefore, for the current study, it was decided to choose the Rodhradigana Udvartana followed by Bhaspaswedana and Gomaya Mashi Udvartana followed by Bhaspaswedana as a comparative study. The purpose of the current study is to document and examine this process for statistical interpretation. Aim: Evaluation of Comparative efficacy of Rodhradi Gana Udvartana with Bhaspaswedana and Gomaya Mashi Udvartana with Bhaspawedana in the management of Sthoulya (obesity). Material and Methods: Data related to the disease as well as the drug was collected from Samhitas, other classical Ayurvedic literature, and various modern science books. Subjects visited to outdoor and indoor Panchakarma department and from the specialty camps were registered for the present study. Result: Significant improvement was observed in both groups and during comparison, more results were found in the Gomaya Mashi group (Group B). Conclusion: Udvartana with Gomaya Mashi followed by Bhaspasweda is more effective than Udvartana with Rodhradi Gana followed by Bhaspasweda in the management of Sthoulya (Overweight) and is an economical alternative without adverse effects.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4367
Shriniwas Jadhav, A. V, Mahesh S
Introduction: As per WHO reports, 170 WHO member states have been practicing various indigenous traditional medicines. For the global reorganisation of Ayurvedic drugs advanced standardisation techniques may be involved to maintain quality assurance. Madhumalini Vasant Ras (MVR) is a well-known Ayurvedic herbo-mineral formulation used in the treatment of IUGR (Intra Uterine Growth Retardation). This formulation is not mentioned in the Ayurveda Formulary of India and there is no data on the quality standards of MVR available. So in this study, preliminary data on physicochemical analysis along with HPTLC evaluation of Madhumalini vasant Ras is generated. Aim and objective: To evaluate and generate data on the physicochemical parameters of the MVR tablet. Materials and Method: The raw drugs were authenticated by experts of Dravya Guna and Rassastra Bhaishajya Kalpana departments and tablets (125 mg) were prepared at the pharmacy, Parul institute of Ayurveda, Vadodara. Then the physico-chemical parameters and microbial limits were checked and HPTLC analysis was done. Results: While evaluating the physicochemical parameters, the pH value was 4.19, LOD 6.01%, Total ash value 11.54%, Acid insoluble ash 8.70%, water-soluble extractive value was 22.20% w/w, alcohol soluble extractive value was 13.40% w/w, HPTLC at 254 nm and at 366 nm showed five common spots. The Microbiological analysis shows that the formulation is free from microbes. Conclusion: Preliminary data on organoleptic characters, antimicrobial evaluation, various physicochemical parameters and HPTLC of MVR tablet is generated. These data can be used as a standard for future standardization studies.
{"title":"Preliminary Physicochemical Evaluation of Madhumalini Vasant Ras tablet – An Ayurveda Herbo-mineral Formulation","authors":"Shriniwas Jadhav, A. V, Mahesh S","doi":"10.47552/ijam.v15i2.4367","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4367","url":null,"abstract":"Introduction: As per WHO reports, 170 WHO member states have been practicing various indigenous traditional medicines. For the global reorganisation of Ayurvedic drugs advanced standardisation techniques may be involved to maintain quality assurance. Madhumalini Vasant Ras (MVR) is a well-known Ayurvedic herbo-mineral formulation used in the treatment of IUGR (Intra Uterine Growth Retardation). This formulation is not mentioned in the Ayurveda Formulary of India and there is no data on the quality standards of MVR available. So in this study, preliminary data on physicochemical analysis along with HPTLC evaluation of Madhumalini vasant Ras is generated. Aim and objective: To evaluate and generate data on the physicochemical parameters of the MVR tablet. Materials and Method: The raw drugs were authenticated by experts of Dravya Guna and Rassastra Bhaishajya Kalpana departments and tablets (125 mg) were prepared at the pharmacy, Parul institute of Ayurveda, Vadodara. Then the physico-chemical parameters and microbial limits were checked and HPTLC analysis was done. Results: While evaluating the physicochemical parameters, the pH value was 4.19, LOD 6.01%, Total ash value 11.54%, Acid insoluble ash 8.70%, water-soluble extractive value was 22.20% w/w, alcohol soluble extractive value was 13.40% w/w, HPTLC at 254 nm and at 366 nm showed five common spots. The Microbiological analysis shows that the formulation is free from microbes. Conclusion: Preliminary data on organoleptic characters, antimicrobial evaluation, various physicochemical parameters and HPTLC of MVR tablet is generated. These data can be used as a standard for future standardization studies.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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