A microRNA-related single nucleotide polymorphism of the Dicer gene is associated with risk of dermatomyositis

Pub Date : 2023-04-26 DOI:10.1177/1721727x231173526
Chenxing Peng, Jingjing Zhang, Shasha Zhang, Xiaoyun Zhang, Yufei Zhao
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引用次数: 1

Abstract

To evaluate the correlation of miRNA-related single nucleotide polymorphisms (miR-SNPs) with the risk of dermatomyositis (DM) development. MicroRNAs (MiRNAs) are involved in a variety of activities such as cell differentiation, proliferation, apoptosis, tumorigenesis, and immunological response. MiR-SNPs alter the expression levels of miRNAs, leading to increased susceptibility to DM. We genotyped six miR-SNPs for miRNA processing machinery genes, including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), and two miR-SNPs for microRNA binding site, including SET8 (rs16917496), and KRT81 (rs3660), in a case-control study to assess the impact of these miR-SNPs on DM risk. Then we assessed cytokine expression and ROS levels in DM to determine the relationship between risk-related miR-SNPs and cytokines. We discovered that Dicer’s (rs3742330) AA genotype had a decreased chance of developing DM than the AG + GG type (odds ratio, 0.527; 95% confidence interval: 0.281–0.987; p = 0.045). The subsequent analysis showed that the AA genotype carrier had greater levels of IL-4 ( p = 0.034). The SNP of Dicer (rs3742330) maybe an attractive predictor of DM, moreover the cytokine of IL-4 may act as the factor that distinguishes SNP of Dicer (rs3742330) into AA and AG + GG.
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Dicer基因微小核糖核酸相关单核苷酸多态性与皮肌炎风险相关
评估mirna相关单核苷酸多态性(mir - snp)与皮肌炎(DM)发展风险的相关性。MicroRNAs (MiRNAs)参与多种活动,如细胞分化、增殖、凋亡、肿瘤发生和免疫反应。在一项病例对照研究中,我们对6个miRNA加工机制基因的mir - snp进行了基因分型,包括XPO5 (rs11077)、RAN (rs14035)、Dicer (rs3742330)、TNRC6B (rs9623117)、GEMIN3 (rs197412)和GEMIN4 (rs2740348),以及2个microRNA结合位点的mir - snp,包括SET8 (rs16917496)和KRT81 (rs3660),以评估这些mir - snp对DM风险的影响。然后,我们评估了DM中的细胞因子表达和ROS水平,以确定风险相关的mir - snp与细胞因子之间的关系。我们发现Dicer 's (rs3742330) AA基因型比AG + GG型发生糖尿病的几率低(优势比,0.527;95%置信区间:0.281-0.987;P = 0.045)。随后的分析表明,AA基因型携带者IL-4水平较高(p = 0.034)。Dicer (rs3742330) SNP可能是DM的重要预测因子,IL-4细胞因子可能是区分Dicer (rs3742330) SNP为AA和AG + GG的重要因素。
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