Recapitulating The Etiology And Pathophysiology Of Obesity Epidemic: A Comprehensive Guide To Associated Biomarkers And Pharmacotherapy

Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Pharmaceutical Negative Results Pub Date : 2023-02-11 DOI:10.47750/pnr.2023.14.1s02.300
{"title":"Recapitulating The Etiology And Pathophysiology Of Obesity Epidemic: A Comprehensive Guide To Associated Biomarkers And Pharmacotherapy","authors":"Kirti Goel, Randhir Singh, Vipin Saini, Seema Bansal","doi":"10.47750/pnr.2023.14.1s02.300","DOIUrl":null,"url":null,"abstract":"Obesity or Adiposity is a worldwide common health problem that is related with an augmented risk of a number of medical conditions, morbidity and mortality. This mini review recapitulates the epidemiology, Etiology, associated comorbidities, biomarkers and available pharmacotherapy of obesity. The epidemiology of obesity is increasing in low-, middle- and high-income countries, with sociodemographic, behavioural, and genetic factors all playing a role. Comorbidities include hypertension, diabetes mellitus, stroke, coronary artery disease, and melanoma. Biomarkers associated with obesity include anthropometric markers, biochemical markers, hormonal markers, molecular biomarkers. Obesity related Oxidative stress is also discussed in this paper as per current findings from various clinical and preclinical data available up to January 2023.Treatment approaches range from lifestyle changes to pharmacotherapy and surgery. The available pharmacotherapy is either connected with precarious ill effects or overpriced, therefore, alternative therapies for obesity attenuation are required. Article under discussion provides an insight into oxidative stress attenuation, gene therapy via biomarkers regulation for combating obesity. Prevention strategies should include multidimensional approaches tailored to each nation","PeriodicalId":16728,"journal":{"name":"Journal of Pharmaceutical Negative Results","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Negative Results","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47750/pnr.2023.14.1s02.300","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0

Abstract

Obesity or Adiposity is a worldwide common health problem that is related with an augmented risk of a number of medical conditions, morbidity and mortality. This mini review recapitulates the epidemiology, Etiology, associated comorbidities, biomarkers and available pharmacotherapy of obesity. The epidemiology of obesity is increasing in low-, middle- and high-income countries, with sociodemographic, behavioural, and genetic factors all playing a role. Comorbidities include hypertension, diabetes mellitus, stroke, coronary artery disease, and melanoma. Biomarkers associated with obesity include anthropometric markers, biochemical markers, hormonal markers, molecular biomarkers. Obesity related Oxidative stress is also discussed in this paper as per current findings from various clinical and preclinical data available up to January 2023.Treatment approaches range from lifestyle changes to pharmacotherapy and surgery. The available pharmacotherapy is either connected with precarious ill effects or overpriced, therefore, alternative therapies for obesity attenuation are required. Article under discussion provides an insight into oxidative stress attenuation, gene therapy via biomarkers regulation for combating obesity. Prevention strategies should include multidimensional approaches tailored to each nation
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肥胖症流行的病因和病理生理学综述:相关生物标志物和药物治疗的综合指南
肥胖或肥胖是一个世界范围内常见的健康问题,它与许多疾病、发病率和死亡率的风险增加有关。这篇综述概述了肥胖症的流行病学、病因学、相关合并症、生物标志物和可用药物治疗。在低收入、中等收入和高收入国家,肥胖的流行病学正在增加,社会人口、行为和遗传因素都在发挥作用。合并症包括高血压、糖尿病、中风、冠状动脉疾病和黑色素瘤。与肥胖相关的生物标志物包括人体测量标志物、生化标志物、激素标志物、分子生物标志物。根据截至2023年1月的各种临床和临床前数据的最新发现,本文还讨论了肥胖相关的氧化应激。治疗方法包括改变生活方式、药物治疗和手术。现有的药物治疗要么与不稳定的不良反应有关,要么价格过高,因此需要替代疗法来减轻肥胖。文章讨论提供了深入了解氧化应激衰减,基因治疗通过生物标志物调控对抗肥胖。预防战略应包括适合每个国家的多层面的办法
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
相关文献
Drug reimbursement and GPs’ prescribing decisions: a randomized case-vignette study about the pharmacotherapy of obesity associated with type 2 diabetes: how GPs react to drug reimbursement
IF 2.9 4区 医学Fundamental & Clinical PharmacologyPub Date : 2010-07-06 DOI: 10.1111/j.1472-8206.2009.00779.x
Pierre Verger, Sophie Rolland, Alain Paraponaris, Julien Bouvenot, Bruno Ventelou
A Clinical Guide to the Treatment of Cellulite and Comprehensive Review of the Etiology, Pathophysiology, and Utility of Intervention
IF 2 3区 医学Aesthetic Plastic SurgeryPub Date : 2023-12-06 DOI: 10.1007/s00266-023-03762-9
Ambika Menon, Orr Shauly, Troy Marxen, Albert Losken, Heather R. Faulkner
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Chinese Spinach (Amaranthus viridis Linn.) as Natural Molluscicide Against the Hatchability of Golden Apple Snail (Pomacea canaliculata Lamarck) Eggs Molluscicidal Activity Of Cashew (Anarcadium Occidentale Linn.) Apple Against Golden Apple Snail (Pomacea Canaliculata Lamarck) Effectiveness Of Simulation- Based Learning In Term Of Competency Regarding Pre-Term Newborn Care Among Nursing Students: An Quasi Experimental Study Synthesis, Characterization, Antibacterial Activity And Molecular Docking Studies Of Novel Nitrogen Based Indole-2-One Schiff’s Bases Emergency Obstetric Complications During Labour And Delivery Among Mothers Attending Maternity Teaching Hospital /Erbil City/ Iraq. A Cross-Sectional Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1