{"title":"Ionic liquid mediated and promoted one-pot green synthesis of new isoxazolyl dihydro-1H-indol-4(5H)-one derivatives at ambient temperature","authors":"Nagi Reddy Modugu, Praveen Kumar Pittala","doi":"10.1080/23312009.2017.1318693","DOIUrl":null,"url":null,"abstract":"Abstract We report a mild, inexpensive, fast, highly efficient, and eco-friendly protocol for the synthesis of new isoxazolyl dihydro-1H-indol-4(5H)-ones by a catalyst-free, one-pot three-component reaction of 4-amino-3-methyl-5-styrylisoxazoles, dimedone, and 2-chloroacetophenones under 1-methyl imidazolium tetraflouroborate ([HMIm]BF4) as task-specific ionic liquid at room temperature. The important aspects of the present methodology are: use of green solvent, short reaction time, catalyst free, compatibility with wide range of substrates, ease of recovery, reusability of reaction medium, and good yields.","PeriodicalId":10640,"journal":{"name":"Cogent Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23312009.2017.1318693","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cogent Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23312009.2017.1318693","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Abstract We report a mild, inexpensive, fast, highly efficient, and eco-friendly protocol for the synthesis of new isoxazolyl dihydro-1H-indol-4(5H)-ones by a catalyst-free, one-pot three-component reaction of 4-amino-3-methyl-5-styrylisoxazoles, dimedone, and 2-chloroacetophenones under 1-methyl imidazolium tetraflouroborate ([HMIm]BF4) as task-specific ionic liquid at room temperature. The important aspects of the present methodology are: use of green solvent, short reaction time, catalyst free, compatibility with wide range of substrates, ease of recovery, reusability of reaction medium, and good yields.
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