Evaluation of antidepressant effects of zoledronate in rats

IF 0.9 4区 计算机科学 Q3 COMPUTER SCIENCE, THEORY & METHODS International Journal of Parallel Programming Pub Date : 2021-01-15 DOI:10.18231/J.IJPP.2020.038
M. Robin, P. Udaykumar
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引用次数: 0

Abstract

Introduction: Depression is often associated with low bone mineral density. It has been reported that antidepressants, particularly in elderly people, are a cause of low bone strength and fractures. Also it has been found that the antidepressants targeting the serotonin system are harmful for bone health and induce osteoporosis. A relationship between depression and osteoporosis has become more evident over the years, as reduced bone mineral density has been noticed in both depressed women and men. Aged men are more susceptible to the effects of depression on BMD than older women. It has also been observed from different studies that depressed men have lower bone mineral density than non-depressed men. Studies on animals have also indicated that depression may predispose to osteoporosis. Recent long-term studies have also shown that women with menopausal status are at higher risk of depression and osteoporosis. The positive effects of bisphosphonates, including improvement in anxiety or depression, is an area of research in the recent years.The application of bisphosphonates, especially risedronate, ibandronate and etidronate in the treatment of depression along with osteoporosis is limited and no studies have been done using zoledronate. Objective: To evaluate the anti-depressant effect of zoledronate in albino rats. Materials and Methods: After obtaining approval from Institutional Animal Ethics Committee, 18 albino rats weighing 150-250 grams were taken and divided into 3 groups of 6 rats each. Group A (Control): Distilled water 10 ml/kg oral; Group B (Standard) Fluoxetine 20 mg/kg oral for 1 week and Group C (Test) – Zoledronate 0.45 mg/kg oral for 1 week. Anti-depressant effect was assessed after 1 week by performing forced swim test and tail suspension test. Data was analysed using one way ANOVA. p value less than 0.05 was considered significant. Results: Zoledronate (0.45 mg/kg) has shown significant reduction in duration of immobility in both forced swim t
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唑来膦酸钠对大鼠抗抑郁作用的评价
抑郁症常与低骨密度有关。据报道,抗抑郁药,特别是老年人,是导致骨强度低和骨折的原因。研究还发现,以血清素系统为靶点的抗抑郁药对骨骼健康有害,可诱发骨质疏松症。多年来,抑郁症和骨质疏松症之间的关系变得更加明显,因为在抑郁症女性和男性中都注意到骨密度降低。老年男性比老年女性更容易受到抑郁症对骨密度的影响。从不同的研究中也观察到,抑郁男性的骨密度低于非抑郁男性。对动物的研究也表明,抑郁症可能易患骨质疏松症。最近的长期研究也表明,处于更年期的妇女患抑郁症和骨质疏松症的风险更高。双膦酸盐的积极作用,包括改善焦虑或抑郁,是近年来的一个研究领域。双膦酸盐,特别是利塞膦酸盐、依班膦酸盐和依地膦酸盐在治疗抑郁症伴骨质疏松症中的应用有限,目前尚无使用唑来膦酸盐的研究。目的:评价唑来膦酸钠对白化病大鼠的抗抑郁作用。材料与方法:经机构动物伦理委员会批准,取体重150 ~ 250 g的白化大鼠18只,分为3组,每组6只。A组(对照组):蒸馏水10 ml/kg口服;B组(标准组)氟西汀20mg /kg口服1周,C组(试验组)唑来膦酸盐0.45 mg/kg口服1周。1周后通过强迫游泳试验和悬尾试验评估抗抑郁效果。数据分析采用单因素方差分析。P值小于0.05被认为是显著的。结果:唑来膦酸钠(0.45 mg/kg)在两组强迫游泳组中均能显著减少静止时间
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来源期刊
International Journal of Parallel Programming
International Journal of Parallel Programming 工程技术-计算机:理论方法
CiteScore
4.40
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: International Journal of Parallel Programming is a forum for the publication of peer-reviewed, high-quality original papers in the computer and information sciences, focusing specifically on programming aspects of parallel computing systems. Such systems are characterized by the coexistence over time of multiple coordinated activities. The journal publishes both original research and survey papers. Fields of interest include: linguistic foundations, conceptual frameworks, high-level languages, evaluation methods, implementation techniques, programming support systems, pragmatic considerations, architectural characteristics, software engineering aspects, advances in parallel algorithms, performance studies, and application studies.
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