Regenerative Medicine to Reduce the Side Effects from Radiotherapy Causing Skin Cancer, Fibrosis, Neuropathic Pain and Hair Loss

E. R. Vickers, Junqing Liang, Peter G. Vickers, Haitao Wen
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引用次数: 1

Abstract

Surgery, chemotherapy and radiotherapy are the gold standard treatments used for cancer. Side effects from medical radiation can be significant, particularly external beam therapy to the breast, and head and neck regions causing fibrosis, secondary skin cancer, hair loss, oral mucositis and neuropathic pain. There is significant psychological stress, depression, anxiety and loss of self esteem particularly for female patients. Similar types of space radiation are known to damage the health of astronauts. Current treatments for scarring, tissue loss, hair loss and neuropathic pain are a high priority but inadequate. Regenerative medicine is a new and comprehensive approach to potentially treat complex medical conditions from radiation damage. Regenerative medicine combines a systematic evidence based approach with the use of herbal medicine, stem cells, peptides and 3D tissue engineering. These fields use sophisticated technology to identify the respective molecular mechanisms of upregulation and protection of healthy cells and down regulation of cancer cells. The regenerative medicine strategies of stem cells and plant polyphenols suggest there is significant potential for rapid clinical translation to alleviate the side effects associated with radiotherapy.
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再生医学减少放射治疗引起皮肤癌症、纤维化、神经性疼痛和脱发的副作用
手术、化疗和放疗是治疗癌症的黄金标准疗法。医疗放射的副作用可能很严重,特别是对乳房和头颈部区域进行外部放射治疗,可引起纤维化、继发性皮肤癌、脱发、口腔黏膜炎和神经性疼痛。女性患者有明显的心理压力、抑郁、焦虑和自尊丧失。众所周知,类似类型的太空辐射会损害宇航员的健康。目前对疤痕、组织损失、脱发和神经性疼痛的治疗是高度优先的,但还不够。再生医学是一种新的综合方法,有可能治疗辐射损伤引起的复杂医疗状况。再生医学结合了系统的证据为基础的方法与使用草药,干细胞,多肽和3D组织工程。这些领域使用复杂的技术来确定健康细胞的上调和保护以及癌细胞的下调各自的分子机制。干细胞和植物多酚的再生医学策略表明,在快速临床转化以减轻放射治疗相关副作用方面具有重大潜力。
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