Serum levels of interleukin (IL)-33 in patients with ischemic heart disease

Abstract

Objective:It has been reported that cytokines play a crucial role in pathogenesis of different diseases such as cardiovascular diseases. The aim of this study was to evaluated the serum level of IL-33 in patients with ischemic heart disease (IHD) and also clarify its association with traditional risk factors of the disease. Methods:A total of 300 patients with IHD as having acute myocardial infarction (AMI; n=100), unstable angina (UA; n=100) or stable angina (SA; n=100) and 100 sex- and age- matched healthy subjects as control group (n=100) were enrolled to this cross-sectional, case controlled study. Serum samples were collected from all participants and tested for IL-33 by use of ELISA method. Results:The mean serum concentration of IL-33 in AMI (103.3319.29 Pg/ml), SA (157.6033.43 Pg/ml) and UA (122.21 22.26 Pg/ml) was significantly higher than that observed in healthy control (61.857.67 Pg/ml). There was no significant difference between patient with or without certain traditional risk factor including hypertensionve patients, dyslipidemic patients, smokinger, obesity e patients and diabetesic patients in the mean serum level of IL-33. Conclusion:These results showed that the higher serum concentration of IL-33 was associated with IHD. The presence or absence of certain traditional risk factors of IHD did not influence the serum level of cytokines.