Efficient Cross-Coupling Reaction of Aryltrifluoroborates and Aroyl Chlorides for the Synthesis of Fluorine Substituted Aromatic Ketones

Mohammed Al-Masum, Tasfia Islam, Grady Clopton
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Abstract

The direct aroylation of ArCOPdCl with potassium aryltrifluoroborates establishes a new cross-coupling synthetic tool for the synthesis of various fluorine substituted benzophenones. The new microwave irradiated process is very efficient and produce high yield benzophenone products within minutes.
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三氟硼酸芳酯与芳酰氯高效交联反应合成氟取代芳酮
ArCOPdCl与芳基三氟硼酸钾的直接芳基化反应为合成各种氟取代二苯甲酮提供了一种新的交叉偶联合成工具。新的微波辐照工艺效率高,可在几分钟内生产出高收率的二苯甲酮产品。
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