An approach to treat conundrumof skin cancer: Bioactive loaded Niosomes

Abstract

Skin cancer is a life-threatening disease according to the World Health Organization, majorly affecting the white population. The major concerning factors that are responsible for skin cancer are genetic factors, environmental exposure including UV rays and pollutants. The UV radiations excessively generate Reactive oxygen species (ROS) and Reactive nitrogen species (RNS)due to which the oxidative stress mediates and alters numerous signaling pathways. Quercetin is a flavonoid that plays a vital role in protecting the cell from oxidative stressin addition to possessing anticancer, antioxidant, and anti-inflammatory properties. The present article focuses on the delivery of natural flavonoid quercetin via novel carrier noisome to enhance targeting and safety efficacy. The risk of developing skin cancer arises from a combination of genetic and environmental factors, the most common cause being prolonged exposure to ultraviolet (UV) light. Quercetin is a flavanoid that plays a vital role in protecting cell from oxidative stress that are activated by reactive oxygen species. It has been hence proved that the reactive oxygen species (ROS) and reactive nitrogen species (RNS) forms on of the basic cause of cancer. The drug carrier noisome enhances the bioavailability of the natural products and have an advantage of solubilizing the lipophilic compound and prevent them from deuteriation into “antagonist” condition in human blood. Thus, current research work focuses over designing and characterization of niosomes system for the treatment of skin cancer and target oxidative stress. Though many novel drug deliveries have been designed as carrier system in skin cancer, among all niosomes have been found as potential colloidal carrier. Quercetin loaded niosomes were developed and was optimized, characterized for morphological studies, entrapment efficiency, zeta potential and In vitro drug release. The quercetin loaded niosomal vesicles under the transmission electron microscope were found in range of 120 nm with suitable zeta potential and entrapment efficiency above 80% with control release profile. Formulation was successfully prepared which can be further carried out for in vivo studies.