Rimma G. Savchenko, Natalya A. Veskina, Viktor N. Odinokov, Galina V. Benkovskaya, Lyudmila V. Parfenova
{"title":"Ecdysteroids: isolation, chemical transformations, and biological activity","authors":"Rimma G. Savchenko, Natalya A. Veskina, Viktor N. Odinokov, Galina V. Benkovskaya, Lyudmila V. Parfenova","doi":"10.1007/s11101-021-09792-y","DOIUrl":null,"url":null,"abstract":"<div><p>Ecdysteroids are polyhydroxylated sterols, and are widespread in the plant and animal world. To date, over 520 ecdysteroids have been isolated from natural sources. The most accessible and studied representative of this class of compounds is 20-hydroxyecdysone (20E)—a universal hormone for the development and vital activity of insects and crustaceans. Moreover, ecdysteroids exhibit a wide spectrum of pharmacological activity for humans, without exerting toxic, androgenic, or estrogenic effects. In this regard, the search for new structures of ecdysteroids and their semi-synthetic analogs obtained as a result of various chemical transformations is in high demand. The review summarizes data for the period 2011–2021 regarding recent advances in the isolation of novel natural ecdysteroids, the chemical modifications, biological activity of semi-synthetic analogs and their prospects for practice.</p></div>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":"21 5","pages":"1445 - 1486"},"PeriodicalIF":7.3000,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s11101-021-09792-y","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 9
Abstract
Ecdysteroids are polyhydroxylated sterols, and are widespread in the plant and animal world. To date, over 520 ecdysteroids have been isolated from natural sources. The most accessible and studied representative of this class of compounds is 20-hydroxyecdysone (20E)—a universal hormone for the development and vital activity of insects and crustaceans. Moreover, ecdysteroids exhibit a wide spectrum of pharmacological activity for humans, without exerting toxic, androgenic, or estrogenic effects. In this regard, the search for new structures of ecdysteroids and their semi-synthetic analogs obtained as a result of various chemical transformations is in high demand. The review summarizes data for the period 2011–2021 regarding recent advances in the isolation of novel natural ecdysteroids, the chemical modifications, biological activity of semi-synthetic analogs and their prospects for practice.
期刊介绍：
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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