{"title":"The role of AMP-activated protein kinase in ischemic heart disease","authors":"Long Yang","doi":"10.3760/CMA.J.ISSN.1673-4378.2019.12.019","DOIUrl":null,"url":null,"abstract":"Effective prevention and treatment of perioperative myocardial ischemia-reperfusion injury is an important problem to be urgently solved by multiple disciplines. Optimizing the energy metabolism of ischemic myocardium is essential to alleviate myocardial ischemia/reperfusion injury. It has been confirmed that AMP-activated protein kinase (AMPK) is an important hub of energy metabolism, and can reduce ischemic myocardial injury by increasing glucose uptake, promoting autophagy and inhibiting apoptosis. This paper summarizes the protective effect and mechanism of AMPK in ischemic heart disease, and provides theoretical evidence for seeking the strategy of preventing and treating myocardial ischemia/reperfusion injury with AMPK as the target. \n \n \nKey words: \nAMP-activated protein kinase; Myocardial ischemia; Energy metabolism","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"40 1","pages":"1178-1182"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际麻醉学与复苏杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2019.12.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Effective prevention and treatment of perioperative myocardial ischemia-reperfusion injury is an important problem to be urgently solved by multiple disciplines. Optimizing the energy metabolism of ischemic myocardium is essential to alleviate myocardial ischemia/reperfusion injury. It has been confirmed that AMP-activated protein kinase (AMPK) is an important hub of energy metabolism, and can reduce ischemic myocardial injury by increasing glucose uptake, promoting autophagy and inhibiting apoptosis. This paper summarizes the protective effect and mechanism of AMPK in ischemic heart disease, and provides theoretical evidence for seeking the strategy of preventing and treating myocardial ischemia/reperfusion injury with AMPK as the target.
Key words:
AMP-activated protein kinase; Myocardial ischemia; Energy metabolism
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