A case of adult‐onset diffuse midline glioma diagnosed by histone H3K27M immunostaining after death, which required differentiation from brainstem encephalitis and myelitis
Natsuko Togawa, Masahiro Mitsuhashi, H. Yamashita, S. Minamiguchi, Y. Arakawa, T. Ayaki, A. Kuzuya, A. Ikeda, Ryosuke Takahashi
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Abstract
H3K27M‐mutant diffuse midline glioma is a malignant glioma that was newly added to the World Health Organization classification in 2016. In diffuse midline glioma, the H3K27M‐mutant sometimes develops sub‐acutely and requires a differential diagnosis from encephalomyelitis. Here, we report a case of adult‐onset diffuse midline glioma that was diagnosed by immunostaining for histone H3K27M after death. The present case required a differential diagnosis of autoimmune cervical myelitis and brainstem encephalitis.
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