An experimental evaluation of therapeutic effect of Rosa damascena in hepatotoxicity induced by isoniazid

IF 0.9 4区计算机科学 Q3 COMPUTER SCIENCE, THEORY & METHODS International Journal of Parallel Programming Pub Date : 2021-04-15 DOI:10.18231/J.IJPP.2021.009

I. Khan, M. Nasiruddin, S. Arif

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Abstract

Objectives: Hepatotoxicity occurs as a side effect of first line anti-tubercular drug such as Isoniazid. The aim of the present study was to evaluate therapeutic potential of ethanolic extract of Rosa damascene flowers (RDEE) in isoniazid induced hepatotoxicity in rats. Methods: Rats were given orally isoniazid (50 mg/kg) for 28 days. Silymarin (50 mg/kg) was administered, as standard drug. From 29th to 43rd day of the study, isoniazid was stopped and therapeutic agents such as normal saline, silymarin, RDEE 1.5g/kg and 3g/kg were given orally in different animal groups respectively. On 44th day, blood samples were collected for biochemical analysis and liver tissue was subjected to histopathological examination. Results: The rats administered RDEE showed significant reduction in the liver marker enzymes and total bilirubin treated as compared to negative control group. There was also significant improvement in antioxidant levels and histopathological scores in RDEE treated group in comparison to the negative control group. Conclusion: This study demonstrates the beneficial effect of ethanolic extract of Rosa damascene flowers (RDEE) as a therapeutic agent in hepatotoxicity induced by isoniazid in a dose dependant manner. Keywords: Rosa damascene, Hepatoprotective, Isoniazid, Silymarin, Tuberculosis, Hepatotoxicity.

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大马士革罗莎治疗异烟肼肝毒性的实验评价

目的:肝毒性是一线抗结核药物如异烟肼的副作用。本研究旨在评价大马士革玫瑰乙醇提取物(RDEE)对异烟肼所致大鼠肝毒性的治疗潜力。方法:大鼠口服异烟肼(50 mg/kg) 28 d。给予水飞蓟素(50 mg/kg)作为标准药物。研究第29 ~ 43天，各组停用异烟肼，分别口服生理盐水、水飞蓟素、RDEE 1.5g/kg、3g/kg等治疗药物。第44天采血进行生化分析，并对肝组织进行组织病理学检查。结果:与阴性对照组相比，RDEE组大鼠肝脏标志物酶和总胆红素显著降低。与阴性对照组相比，RDEE治疗组抗氧化水平和组织病理学评分也有显著改善。结论:大马士革玫瑰醇提物对异烟肼所致肝毒性有一定的治疗作用，且呈剂量依赖性。关键词:大马士革玫瑰，保肝，异烟肼，水飞蓟素，结核，肝毒性

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来源期刊

International Journal of Parallel Programming 工程技术-计算机：理论方法

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Parallel Programming is a forum for the publication of peer-reviewed, high-quality original papers in the computer and information sciences, focusing specifically on programming aspects of parallel computing systems. Such systems are characterized by the coexistence over time of multiple coordinated activities. The journal publishes both original research and survey papers. Fields of interest include: linguistic foundations, conceptual frameworks, high-level languages, evaluation methods, implementation techniques, programming support systems, pragmatic considerations, architectural characteristics, software engineering aspects, advances in parallel algorithms, performance studies, and application studies.