Silymarin: A Phytoconstituent with Significant Therapeutic Potential - A Narrative Review

IF 0.3 Q4 PHARMACOLOGY & PHARMACY Current Drug Therapy Pub Date : 2022-12-27 DOI:10.2174/1574885518666221227100052

Pravin Kumar, Sahil Sharma, M. Ashawat, V. Pandit, Chandrapal Verma, Dinesh Kumar Sharma

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Abstract

Silymarin, is a phytoactive constituent isolated from the fruits and seeds of Silybum marianum L Gaetn.), also called milk thistle belonging to the family of Asteracease. The phytoactive has been used to treat several physiological disorders. The objective of this manuscript was to review the therapeutic prospective of silymarin due to its ability to treatseveral physiological disorders. The databases such as Pubmed, Elsevier, and Google Scholar were reviewed for the investigations or reviews published related to the title. The discussion is focused on the immunomodulatory, chemopreventive, and anti-inflammatory mechanisms of silymarin in various metabolic and dermatological disorders. In addition, the review discusses the different therapeutic potentials of silymarin such as the management of the liver disorder, skin carcinogenesis, cardiovascular disorders, diabetes mellitus, neurodegenerative disorders, and several dermatological disorders such as melasma, anti-aging, acne, rosacea, atopic dermatitis, and psoriasis. Silymarin is safe even with a dose higher than the therapeutic dose. Silymarin had good potential for the safe and effective treatment of numerous metabolic and dermatological disorders.

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水飞蓟素:一种具有显著治疗潜力的植物成分

水飞蓟素是从水飞蓟的果实和种子中分离的植物活性成分），也被称为乳蓟，属于菊科。这种植物活性物质已被用于治疗几种生理疾病。本文的目的是综述水飞蓟素的治疗前景，因为它能够治疗几种生理疾病。Pubmed、Elsevier和Google Scholar等数据库被审查了与该标题相关的调查或评论。讨论的重点是水飞蓟素在各种代谢和皮肤病中的免疫调节、化学预防和抗炎机制。此外，该综述还讨论了水飞蓟素的不同治疗潜力，如治疗肝病、皮肤癌变、心血管疾病、糖尿病、神经退行性疾病和几种皮肤病，如黄褐斑、抗衰老、痤疮、酒渣鼻、特应性皮炎和牛皮癣。水飞蓟素即使剂量高于治疗剂量也是安全的。水飞蓟素在安全有效治疗多种代谢和皮肤病方面具有良好的潜力。

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来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.