Effectiveness and safety of Shenmai injection in treatment of shock: a Meta-analysis

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional Chinese Medicine Pub Date : 2018-04-01 DOI:10.1016/j.jtcm.2017.05.001
Li Xiaoli , Shen Yi , He Fan , Zhu Yinchao , Li Fudong
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引用次数: 6

Abstract

OBJECTIVE

To evaluate the effectiveness and safety of Shenmai injection for shock.

METHODS

Randomized controlled trials (RCTs) that evaluated the therapeutic effect of Shenmai injection on shock (including septic shock, cardiogenic shock, hypovolemic shock, neurogenic shock and anaphylactic shock) were included in this analysis. The major electronic databases were searched until May 2015. The methodological quality of the trials was assessed according to the Cochrane Handbook. Review Manager 5.3 and Stata 12.0 software were applied for data analysis.

RESULTS

Thirty RCTs involving 2038 participants were included. The methodological quality of the trials was generally passable. The combined use of Shenmai injection and conventional medicine was significantly more effective at managing shock compared to conventional medicine alone in the outcomes of total effective rate [risk ratio (RR) 1.25, 95% confidence interval (CI) 1.18 to 1.31] and mortality rate [risk difference (RD) – 0.10, 95% CI – 0.17 to – 0.02]. Likewise, improvements were observed in other metrics. Three trials reported adverse events, but no trial reported serious adverse effects.

CONCLUSION

Our results indicated the potential effectiveness of Shenmai injection combined with conventional medicine treatment for shock. However, further rigorously designed trials are needed to collect and weigh up all the evidence for the use of Shenmai injection.

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参麦注射液治疗休克的有效性和安全性:meta分析
目的评价参麦注射液治疗休克的有效性和安全性。方法采用随机对照试验(rct)评价参麦注射液治疗感染性休克、心源性休克、低血容量性休克、神经源性休克和过敏性休克的疗效。主要的电子数据库被搜索到2015年5月。试验的方法学质量根据Cochrane手册进行评估。采用Review Manager 5.3和Stata 12.0软件进行数据分析。结果共纳入30项随机对照试验,共2038名受试者。试验的方法学质量一般是可以通过的。参麦注射液联合常规药物治疗休克在总有效率[风险比(RR) 1.25, 95%可信区间(CI) 1.18 ~ 1.31]和死亡率[风险差(RD) - 0.10, 95% CI - 0.17 ~ - 0.02]两方面均显著优于常规药物治疗。同样,在其他指标中也观察到改进。三个试验报告了不良事件,但没有试验报告严重的不良反应。结论参麦注射液联合常规药物治疗休克具有潜在的疗效。然而,需要进一步严格设计试验来收集和权衡使用参麦注射液的所有证据。
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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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