Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold

IF 7.1 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Topics in Current Chemistry Pub Date : 2022-02-05 DOI:10.1007/s41061-022-00365-x

Ranjana Aggarwal, Mona Hooda, Prince Kumar, Garima Sumran

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引用次数: 6

Abstract

The present review article strives to compile the latest synthetic approaches for the synthesis of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities, viz. anticancer, antimicrobial, analgesic and anti-inflammatory, antioxidant, antiviral, enzyme inhibitors (carbonic anhydrase inhibitors, cholinesterase inhibitors, alkaline phosphatase inhibitors, anti-lipase activity, and aromatase inhibitors) and antitubercular agents. The review focuses particularly on the structure–activity relationship of biologically important 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines, which have profound importance in drug design, discovery and development. In silico pharmacokinetic and molecular modeling studies have also been summarized. It is hoped that this review article will be of help to researchers engaged in the development of new biologically active entities for the rational design and development of new target-oriented 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine-based drugs for the treatment of multifunctional diseases.

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1,2,4-三唑[3,4-b][1,3,4]噻二嗪支架的合成及药用研究进展

本文综述了三唑噻二嗪及其衍生物的最新合成方法，以及它们在抗癌、抗菌、镇痛、抗炎、抗氧化、抗病毒、酶抑制剂(碳酸酐酶抑制剂、胆碱酯酶抑制剂、碱性磷酸酶抑制剂、抗脂肪酶活性、芳香化酶抑制剂)和抗结核药物等方面的药理活性。综述了具有重要生物学意义的1,2,4-三唑[3,4-b][1,3,4]噻二嗪类化合物的构效关系，这些化合物在药物设计、发现和开发中具有重要意义。本文还对药物动力学和分子模型的研究进行了综述。希望本文综述能对从事新型生物活性物质开发的研究人员合理设计和开发以1,2,4-三唑[3,4-b][1,3,4]噻二嗪为基础的靶向治疗多功能疾病的新药物有所帮助。图形抽象

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来源期刊

Topics in Current Chemistry Chemistry-General Chemistry

CiteScore

13.70

自引率

1.20%

发文量

期刊介绍： Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.