Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

IF 8.6 2区化学 Q1 Chemistry Topics in Current Chemistry Pub Date : 2022-06-13 DOI:10.1007/s41061-022-00392-8

Miaomiao Wu, Zexi Zhang, Jiaxi Yong, Peer M. Schenk, Dihua Tian, Zhi Ping Xu, Run Zhang

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引用次数: 16

Abstract

Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and thus many Ru(II) complexes have been designed and synthesized for the detection of ions and small biomolecules in biological and environmental samples. In this work, we summarize the research advances in the development of Ru(II) complex-based chemosensors for the determination of ions and small biomolecules, including anions, metal ions, reactive biomolecules and amino acids, with a particular focus on binding/reaction-based chemosensors for the investigation of intracellular analytes’ evolution through luminescence analysis and imaging. The advances, challenges and future research directions in the development of Ru(II) complex-based chemosensors are also discussed.

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基于钌(II)配合物的化学传感器对生物小分子和离子的测定和成像

发光化学传感器是实时测定和成像生物小分子和离子的最有用的工具之一。基于钌(II) (Ru(II))配合物独特的光物理/化学性质，基于Ru(II)配合物的化学传感器的开发近年来受到越来越多的关注，因此许多Ru(II)配合物被设计和合成用于检测生物和环境样品中的离子和小生物分子。在这项工作中，我们总结了基于Ru(II)配合物的化学传感器的研究进展，用于测定离子和小生物分子，包括阴离子，金属离子，活性生物分子和氨基酸，特别关注基于结合/反应的化学传感器，用于通过发光分析和成像研究细胞内分析物的进化。讨论了Ru(II)配合物化学传感器的研究进展、面临的挑战和未来的研究方向。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.