Discordant congenital varicella syndrome in twin pregnancy: a case report.

Abstract

Varicella-zoster virus is a potentially teratogenic agent that can cross the placenta and cause the syndrome of congenital chickenpox, which is characterized by multisystem abnormalities. Fetal involvement has an incidence of less than 2%. The case of a dichorionic-diamniotic twin gestation of 7 weeks, whose mother consulted for symptomatic chickenpox is presented. Several tests were performed that confirmed the diagnosis and acyclovir was prescribed. The evolution of pregnancy was normal until the third trimester, with ultrasound that made us suspect the Varicella involvement of one of the fetuses. The pregnancy came to term and ended by caesarean section, with the affected fetus postnatally diagnosed with congenital chickenpox syndrome. There is no reported case in the current literature of discordant congenital varicella syndrome in twin pregnancy, so it seems a relevant case for study and knowledge of this pathology.