{"title":"Stereospecific Total Synthesis of Putaminoxin 1 By Ring Closing Metathesis and Enantioselective Epoxidation","authors":"Vanam Shekhar, C. Sudhakar, Nagireddy Veerareddy","doi":"10.2174/2213337210666230228105711","DOIUrl":null,"url":null,"abstract":"\n\nThe stereoselective synthesis of putaminoxin 1, a biologically active natural phototoxic lactone has been synthesized from (R)-2-Propyloxirane and Hex-5-en-1-ol. The synthesis involves Jacobsen’s hydrolytic kinetic resolution and ring-closing metathesis as the key steps.\n","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organocatalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213337210666230228105711","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The stereoselective synthesis of putaminoxin 1, a biologically active natural phototoxic lactone has been synthesized from (R)-2-Propyloxirane and Hex-5-en-1-ol. The synthesis involves Jacobsen’s hydrolytic kinetic resolution and ring-closing metathesis as the key steps.
期刊介绍：
Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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