Stereospecific Total Synthesis of Putaminoxin 1 By Ring Closing Metathesis and Enantioselective Epoxidation

IF 0.9 Q4 CHEMISTRY, PHYSICAL Current Organocatalysis Pub Date : 2023-02-28 DOI:10.2174/2213337210666230228105711
Vanam Shekhar, C. Sudhakar, Nagireddy Veerareddy
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引用次数: 0

Abstract

The stereoselective synthesis of putaminoxin 1, a biologically active natural phototoxic lactone has been synthesized from (R)-2-Propyloxirane and Hex-5-en-1-ol. The synthesis involves Jacobsen’s hydrolytic kinetic resolution and ring-closing metathesis as the key steps.
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闭环复合和对映选择性环氧化反应立体定向合成Putaminoxin 1
以(R)-2-丙基氧环烷和己烯-5-烯-1-醇为原料合成了具有生物活性的天然光毒性内酯putaminoxin 1的立体选择性合成。该合成以雅各布森水解动力学分解和合环复分解为关键步骤。
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来源期刊
Current Organocatalysis
Current Organocatalysis CHEMISTRY, PHYSICAL-
CiteScore
2.00
自引率
0.00%
发文量
28
期刊介绍: Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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