Evaluation of novel MicroRNA profile-21 and 191 in oral leukoplakia and oral squamous cell carcinoma in comparison with healthy tissues – A cross-sectional study

IF 0.1 Clinical Cancer Investigation Journal Pub Date : 2021-11-01 DOI:10.4103/ccij.ccij_54_21

K. Muth Lakshmi, K. Lakshmi, A. Kannan, Y. Aniyan

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引用次数: 2

Abstract

Objective: The objective of this study was to identify whether microRNA (miR)-21 and miR-191 could be used as a potential biomarker in patients diagnosed with oral leukoplakia (OL) and oral squamous cell carcinoma. The aim of this study was to evaluate the expression of miR-21 and miR-191 in patients diagnosed with OL and oral squamous cell carcinoma. Materials and Methods: Fifteen patients each diagnosed with OL and oral squamous cell carcinoma and 15 healthy controls were recruited for the study. The miR was extracted from the tissue samples for the evaluation of miR-21 and miR-191 using RT-qPCR. Results: The miR-21 (P = 0.0005) and miR-191 (P = 0.0094) were significantly expressed in oral squamous cell carcinoma in comparison with healthy tissues. The expression of miR-191 was also significantly overexpressed (P = 0.0460) in OL in comparison with healthy tissues. Conclusion: The profile miR-21 and miR-191 could be used as a novel biomarker for oral squamous cell carcinoma and miR-191 could be used as a biomarker for OL.

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与健康组织相比，口腔白斑和口腔鳞状细胞癌中新型微小RNA谱-21和191的评估——一项横断面研究

目的：本研究的目的是确定微小RNA（miR）-21和miR-191是否可以作为口腔白斑（OL）和口腔鳞状细胞癌患者的潜在生物标志物。本研究的目的是评估miR-21和miR-191在诊断为OL和口腔鳞状细胞癌的患者中的表达。材料和方法：本研究招募了15名分别诊断为OL和口腔鳞状细胞癌的患者和15名健康对照。从组织样品中提取miR，用于使用RT-qPCR评估miR-21和miR-191。结果：与健康组织相比，miR-21（P=0.0005）和miR-191（P=0.0094）在口腔鳞状细胞癌中显著表达。与健康组织相比，miR-191在OL中的表达也显著过表达（P=0.0460）。结论：miR-21和miR-191可作为口腔鳞状细胞癌的一种新的生物标志物，miR-191可以作为OL的一种生物标志物。

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Clinical Cancer Investigation Journal ONCOLOGY-

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