Five Year Survival Outcomes of Prospectively Recorded Cohort Data for Older Adults versus Younger Adults with Resected Primary Rectal Cancer

M. Shafiei, P. Beale, P. Blinman
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Abstract

Background: Rectal cancer predominantly occurs in older adults. We aimed to compare the long-term outcomes of older adults (≥70 years) versus younger adults (Methods: Consecutive patients who had resection of a primary rectal cancer between January 1, 2000 and December 31, 2010 were identified from a prospective database at the Concord Repatriation General Hospital and stratified into two age groups: ences in patients, cancer, and treatment characteristics were determined by Chi-square tests. 5-year Overall Survival (OS) and Cancer-Specific Survival (CSS) were determined by the Kaplan-Meier method and by multivariable Cox regression analysis. Results: Of 714 included patients, the mean age was 65.8 years (range, 21 - 92 years). 407 (57%) patients were aged 70 years. Older age (>70 years) predicted more comorbidity (p 70 years), compared with younger adults (Conclusion: Older adults who had had a resection of stage I-IV primary rectal cancer received less neoadjuvant and adjuvant therapy and had worse OS and CSS than their younger counterparts.
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原发性直肠癌切除的老年人与年轻人的前瞻性队列数据的5年生存结果
背景:癌症主要发生在老年人中。我们旨在比较老年人(≥70岁)与年轻人的长期结果(方法:从康科德遣返综合医院的前瞻性数据库中确定2000年1月1日至2010年12月31日期间连续切除原发性直肠癌症的患者,并将其分为两个年龄组:患者的发病率、癌症和治疗特征通过卡方检验确定。5年总生存率(OS)和癌症特异性生存率(CSS)通过Kaplan-Meier方法和多变量Cox回归分析确定。结果:714例患者的平均年龄为65.8岁(21-92岁)。407例(57%)患者年龄在70岁。与年轻人相比,年龄较大(>70岁)的人预测有更多的合并症(p 70岁)(结论:切除I-IV期原发性癌症的老年人接受的新辅助和辅助治疗较少,OS和CSS比年轻人更差。
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