Effect of laparoscopic hepatectomy on immune function, inflammatory factors and prognosis of patients with hepatocellular carcinoma

中国综合临床 Pub Date : 2019-07-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.04.013

Jie Chen, Bin Zhao, Jun Li, Gaofeng Zhang

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Abstract

Objective To study the effect of laparoscopic hepatectomy resection on immune function, inflammatory factors and prognosis of patients. Methods One hundred and four patients with hepatocellular carcinoma admitted Zigong Fourth People′s Hospital from July 2015 to December 2016 were selected as the study subjects.According to the different surgical methods, they were randomly divided into observation group and control group with 52 cases in each group.The control group received open hepatectomy, while the observation group received laparoscopic hepatectomy.The immune function, inflammatory factors, and surgery related indicators were compared between the two groups. Results The observation time of the observation group was significantly longer than that in the control group.The blood loss was significantly less than the control group.Gastrointestinal function recovery time and postoperative hospital stay were significantly shorter than control group (t=7.553, 13.855, 15.100, 16.873, all P<0.01), three days after surgery, the serum IgA, IgG, and IgM levels were significantly higher than control group (t=16.009, 10.076, 14.138, all P<0.01). The levels of IL-6, IL-10 and TNF-α were significantly lower than the control group (t=8.538, 6.851, 11.103, P<0.05, all P<0.01). Conclusion Laparoscopic hepatectomy can promote the recovery of patients after surgery, which may be related to the reduction of immune function inhibition, inflammatory response and other factors. Key words: Liver cancer; Surgical resection; Laparoscopy; Immune function; Inflammatory factors

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腹腔镜肝切除术对肝癌患者免疫功能、炎症因子及预后的影响

目的探讨腹腔镜肝切除术对患者免疫功能、炎症因素及预后的影响。方法选取自贡市第四人民医院2015年7月至2016年12月收治的104例肝细胞癌患者作为研究对象。根据手术方法的不同，随机分为观察组和对照组，每组52例。对照组采用开放式肝切除术，观察组采用腹腔镜肝切除术。比较两组患者的免疫功能、炎症因子和手术相关指标。结果观察组的观察时间明显长于对照组。失血量明显少于对照组。胃肠功能恢复时间和术后住院时间均显著短于对照组（t=7.553、13.855、15.100、16.873，均P<0.01），术后3天血清IgA、IgG和IgM水平均显著高于对照组（t=16.009、10.076、14.138，均<0.01），IL-10和TNF-α显著低于对照组（t=8.538，6.851，11.103，P<0.05，均P<0.01）。关键词：癌症；手术切除；腹腔镜；免疫功能；炎症因子

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.