Jonathan T Pham, W. Wong, Vonn Walter, J. Scow, M. Deutsch, A. Kulaylat
{"title":"Colorectal cancer incidence and mortality: trends from the Pennsylvania Cancer Registry across three decades","authors":"Jonathan T Pham, W. Wong, Vonn Walter, J. Scow, M. Deutsch, A. Kulaylat","doi":"10.2217/crc-2022-0011","DOIUrl":null,"url":null,"abstract":"Aim: This study aims to examine trends in incidence and mortality of colorectal cancer (CRC) using a state-wide registry, focusing on race, age, and rurality. Methods: From 1990 to 2019, CRC age-adjusted incidence and mortality were examined through the Pennsylvania Cancer Registry using Joinpoint Regression to model average annual percent changes (AAPC). Results: In Pennsylvania, there was a decline in incidence (AAPC -1.7) and mortality (AAPC -2.5), consistent regardless of race or cancer stage, with an inflection in the 2000s demonstrating greater rate of decrease. Conversely, patients under 50 saw rising CRC incidence (AAPC 1.8). Rural counties showed higher mortality than urban counties. Conclusion: Across Pennsylvania, the incidence and mortality rates of CRC have decreased over the past three decades, apart from patients under 50.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colorectal Cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/crc-2022-0011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: This study aims to examine trends in incidence and mortality of colorectal cancer (CRC) using a state-wide registry, focusing on race, age, and rurality. Methods: From 1990 to 2019, CRC age-adjusted incidence and mortality were examined through the Pennsylvania Cancer Registry using Joinpoint Regression to model average annual percent changes (AAPC). Results: In Pennsylvania, there was a decline in incidence (AAPC -1.7) and mortality (AAPC -2.5), consistent regardless of race or cancer stage, with an inflection in the 2000s demonstrating greater rate of decrease. Conversely, patients under 50 saw rising CRC incidence (AAPC 1.8). Rural counties showed higher mortality than urban counties. Conclusion: Across Pennsylvania, the incidence and mortality rates of CRC have decreased over the past three decades, apart from patients under 50.
期刊介绍：
Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.
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