SARS-CoV-2: overview of immune response, insights into vaccine platforms and their challenges

B. Omar, Arpana Singh, Vanya Singh, Ashish Kothari, Manju O. Pai
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Abstract

The crown-like shaped viruses known as coronaviruses which were first reported in the 1960’s have caused three epidemics in the past two decades namely, coronavirus disease-19 (COVID-19), severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). SARS coronavirus 2 (SARS-CoV-2) was first reported in the latter half of December in Wuhan, a city of China, with people affected by deadly pneumonia with unknown etiology. Since then, the world has experienced two phases of virus spread with different symptoms and disease severity. This review embarks on the journey to investigate candidate molecules of this virus which can and are being investigated for various vaccine formulations and to discuss immunity developed against this virus.
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严重急性呼吸系统综合征冠状病毒2型:免疫反应概述、对疫苗平台的见解及其挑战
20世纪60年代首次报道的冠状病毒,即冠状病毒,在过去20年中引起了三种流行病,即冠状病毒病-19(新冠肺炎)、严重急性呼吸综合征(SARS)和中东呼吸综合征。SARS冠状病毒2型(严重急性呼吸系统综合征冠状病毒2型)于12月下旬在中国武汉首次报告,患者感染了病因不明的致命肺炎。从那时起,世界经历了病毒传播的两个阶段,症状和疾病严重程度各不相同。这篇综述开始了研究这种病毒的候选分子的旅程,这些分子可以并且正在被研究用于各种疫苗配方,并讨论针对这种病毒产生的免疫力。
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