Iloperidone-induced urinary incontinence in a female patient with schizophrenia: A case report

Q3 Medicine Neurology Psychiatry and Brain Research Pub Date : 2020-06-01 DOI:10.1016/j.npbr.2020.04.001

S.M. Yasir Arafat

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Abstract

Background

Iloperidone, a second-generation antipsychotic has been approved for the management of schizophrenia. Although it has been found well-tolerated multiple side effects have been reported.

Objectives

I report a case of iloperidone-induced urinary incontinence in a Bangladeshi female.

Method

This patient has been taking psychiatric consultations for the last five years. After developing the side effect, informed consent was taken, details of history were obtained, and routine physical examination and mental status of the patient was performed.

Results

I report a case of 20 years old female who developed urinary incontinence due to iloperidone. Her symptoms improved after discontinuing the drug.

Conclusion

This is the first case, reporting urinary incontinence caused by iloperidone in a patient with schizophrenia which could be an effect of bladder neck dysfunction due to the high alpha 1 receptor blockade.

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依哌啶酮致女性精神分裂症患者尿失禁1例

哌啶酮是第二代抗精神病药物，已被批准用于治疗精神分裂症。虽然它的耐受性很好，但据报道有多种副作用。目的报告一例依哌啶酮引起的孟加拉女性尿失禁。方法患者近5年接受精神科会诊。出现副作用后，接受知情同意，详细了解病史，对患者进行常规体检和精神状态检查。结果报告1例20岁女性因服用依哌啶酮而发生尿失禁。停药后她的症状好转了。结论这是首例报告的伊哌啶酮引起的精神分裂症患者尿失禁，可能是由于高α 1受体阻断引起的膀胱颈功能障碍所致。

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来源期刊

Neurology Psychiatry and Brain Research 医学-精神病学

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.